[Form 4] Opko Health Inc. Insider Trading Activity

Rhea-AI Filing Summary

Phillip Frost, M.D., in his capacities as CEO & Chairman, director and reported 10% owner, disclosed multiple changes in his OPKO Health (OPK) holdings. The filing shows on 08/08/2025 a purchase of 675,000 shares at $1.32 per share and a reported disposition of 3,568,951 shares. Following the reported transactions the Form lists indirect beneficial ownership amounts of 214,676,448 shares and 30,127,177 shares, each referenced to separate footnotes.

The footnotes explain these shares are held through Frost-controlled entities and trusts (Frost Gamma Investments Trust and Frost Nevada Investments Trust) with Dr. Frost acting as trustee or related party; the filing states he disclaims beneficial ownership except to the extent of any pecuniary interest. The report is a Section 16 Form 4 disclosure of insider activity and trust relationships only.

Positive

• Insider purchase of 675,000 OPK shares at $1.32, indicating additional direct acquisition activity by the reporting parties
• Detailed trust disclosures clarify ownership pathways through Frost Gamma and Frost Nevada entities

Negative

• Disposition of 3,568,951 OPK shares by the reporting person was also reported, representing a substantial sale
• Large indirect holdings (214,676,448 and 30,127,177 shares) may complicate assessments of direct insider alignment due to trust structures and disclaimers

Insights

Securities Analyst

TL;DR: Insider both purchased and sold OPK shares on 08/08/2025; transactions total a 675,000 share buy at $1.32 and a 3,568,951 share disposition.

The filing documents an intra-day or same-date set of transactions comprising a purchase (code P) of 675,000 shares at $1.32 and a separate reported disposition of 3,568,951 shares. These are explicit, non-derivative equity changes reported under Section 16. From an investor-information perspective this is mixed signaling because the insider executed both buy and sell activity and maintains very large indirect stakes. The filing does not provide timing detail beyond the transaction date, nor does it state the purpose of the transactions.

Corporate Governance Expert

TL;DR: Dr. Frost’s holdings are routed through related trusts and entities; the filing contains detailed disclaimers about beneficial ownership.

The footnotes explicitly state shares are held by Frost Gamma Investments Trust and Frost Nevada Investments Trust, with Dr. Frost serving as trustee and related entities as beneficiaries or general partners. The report includes standard Section 16 disclaimers that he disclaims beneficial ownership except for any pecuniary interest. This structure is clearly documented in the filing and is material to understanding the form of his reported indirect ownership.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

FROST PHILLIP MD ET AL

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	X	10% Owner
X	Officer (give title below)		Other (specify below)
	CEO & Chairman

3. Date of Earliest Transaction (Month/Day/Year)
08/08/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	08/08/2025		P		675,000	A	$1.32	214,676,448	I	See Footnote(1)
Common Stock								3,568,951	D
Common Stock								30,127,177	I	See Footnote(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

FROST PHILLIP MD ET AL

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
X	Officer (give title below)		Other (specify below)
	CEO & Chairman

1. Name and Address of Reporting Person^*

Frost Gamma Investments Trust

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FL 33137

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

2. These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

	Phillip Frost, M.D., Individually and as Trustee	08/08/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What transactions did Phillip Frost report on Form 4 for OPK?

The filing reports a purchase of 675,000 common shares at $1.32 and a disposition of 3,568,951 common shares, with the transaction date listed as 08/08/2025.

How many OPK shares does the Form 4 show as beneficially owned after the transactions?

The Form lists indirect beneficial ownership amounts of 214,676,448 shares and 30,127,177 shares, each referenced to separate footnotes describing trust holdings.

What is Phillip Frost’s relationship to OPKO Health (OPK)?

The filing identifies Phillip Frost as CEO & Chairman, a director, and a reported 10% owner of the issuer.

Are the reported OPK shares held directly by Dr. Frost?

Many shares are reported as held indirectly through Frost Gamma Investments Trust and Frost Nevada Investments Trust; the footnotes describe the trust and partnership structure.

Does Dr. Frost disclaim beneficial ownership in the filing?

Yes. The filing contains explicit disclaimers stating he disclaims beneficial ownership except to the extent of any pecuniary interest, as described in the footnotes.