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Oruka Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing monoclonal antibodies for psoriasis and inflammatory diseases. As of June 30, 2025 the company reported $65.4 million in cash, $286.1 million in marketable securities (totaling $351.5 million), total assets of $357.4 million and stockholders' equity of $343.6 million. For the three and six months ended June 30, 2025 the company recorded net losses of $24.6 million and $45.6 million, respectively, and used $44.0 million of cash in operating activities during the first half of 2025. Research and development was the primary expense, totaling $44.0 million for six months.
The company advanced its pipeline: ORKA-001 (anti-IL-23p19) completed Phase 1 dosing in healthy volunteers, received FDA IND and Health Canada CTA clearances and commenced Phase 2a dosing with the first patient dosed subsequent to the quarter end; ORKA-002 (anti-IL-17A/F) initiated Phase 1 dosing. Oruka holds exclusive licenses with Paragon that include milestone payments (up to $12.0 million clinical and $10.0 million regulatory per program) and low single-digit royalties; it has expensed $4.0 million for each license. Management expects existing cash, cash equivalents and marketable securities to fund operating plans for at least twelve months from issuance of these financial statements.
On July 1, 2025, Oruka Therapeutics, Inc. (ORKA) filed a Form 4 reporting that Chief Operating Officer Laura Lee Sandler received an employee stock option covering 25,000 shares of common stock at an exercise price of $11.80 per share. The option expires on June 30, 2035 and vests 25 % on July 1, 2026, with the remaining 75 % vesting in equal monthly installments thereafter (1⁄48 per month). After the grant, Sandler beneficially owns 25,000 derivative securities; no non-derivative share transactions were disclosed. The filing reflects an incentive-based award rather than an open-market purchase or sale, resulting in no immediate cash flow or share-count impact for investors.
On 07/01/2025, Oruka Therapeutics, Inc. (ORKA) filed a Form 3 reporting the initial beneficial ownership of its newly appointed Chief Operating Officer, Laura Lee Sandler.
- Direct ownership: 213,084 shares of common stock.
- Derivative securities: • Warrant covering 99,996 shares at an exercise price of $7.80, expiring 07/14/2034. Vesting schedule: 25% on 04/03/2025, remaining shares vest monthly over the subsequent three years. • Employee stock option for 137,500 shares at $12.50, expiring 01/21/2035; vests 1/48 monthly beginning 01/01/2025.
- Potential total ownership: 450,580 shares if all derivatives vest and are exercised.
The disclosure signals meaningful insider alignment through equity ownership and a performance-linked vesting structure. No other transactions or financial metrics were included in this filing.