Oruka Therapeutics (ORKA) gains 5.2% stake holder with 3.14M shares

Rhea-AI Filing Summary

RTW Investments, LP and Roderick Wong, M.D. report beneficial ownership of Oruka Therapeutics, Inc. common stock. They collectively report 3,139,030 Shares of common stock, representing 5.2% of the class based on 60,312,101 Shares outstanding as of April 30, 2026.

All 3,139,030 Shares are reported with shared voting and shared dispositive power, with no sole voting or dispositive power. The shares are directly held by funds advised by RTW Investments, and the RTW Funds have the right to receive dividends and sale proceeds. The filing clarifies it should not be construed as an admission of beneficial ownership for any Reporting Person.

Key Figures

Shares beneficially owned: 3,139,030 Shares Percent of class: 5.2% Shares outstanding: 60,312,101 Shares +2 more

5 metrics

Shares beneficially owned 3,139,030 Shares Common stock of Oruka Therapeutics reported by RTW Investments and Roderick Wong

Percent of class 5.2% Ownership percentage of Oruka Therapeutics common stock class for each Reporting Person

Shares outstanding 60,312,101 Shares Oruka Therapeutics common stock outstanding as of April 30, 2026

Shared voting power 3,139,030 Shares Shares over which Reporting Persons have shared power to vote or direct the vote

Shared dispositive power 3,139,030 Shares Shares over which Reporting Persons have shared power to dispose or direct disposition

Key Terms

beneficial owner, shared voting power, shared dispositive power, investment adviser, +2 more

6 terms

beneficial owner regulatory

"the beneficial owner of the Shares reported herein"

A beneficial owner is the person who ultimately owns or controls a financial asset or property, even if their name isn't directly on official documents. Think of it like someone who secretly holds the keys to a safe deposit box—others may appear to have access, but the true owner is the one who benefits from what's inside. Identifying beneficial owners helps ensure transparency and prevent illegal activities like money laundering or fraud.

shared voting power regulatory

"Shared Voting Power 3,139,030.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

shared dispositive power regulatory

"Shared Dispositive Power 3,139,030.00"

investment adviser financial

"the investment adviser to certain funds (the "RTW Funds")"

An investment adviser is a person or firm that professionally manages money and gives recommendations about buying, selling, or holding investments. Like a financial coach or guide, they have a legal duty to act in a client's best financial interest, so their advice, fees and potential conflicts can directly affect returns and risk — making their role important for investors who want informed, accountable help with portfolios.

percent of class financial

"The percentages set forth in Row 11 of the cover pages are calculated"

Percent of class is the portion of a specific category of securities—such as a company’s common shares, preferred shares, or a bond series—that takes part in or approves a corporate action (vote, consent, tender, etc.). Investors watch this number because it reveals how much support or opposition exists within that particular shareholder group; like counting how many members of a club back a proposal, it can determine whether a plan passes or how influence is distributed.

Schedule 13 regulatory

"for the purposes of Section 13 of the Securities Exchange Act of 1934"

FAQ

What ownership stake in ORKA does RTW Investments report?

RTW Investments and Roderick Wong report beneficial ownership of 3,139,030 Shares of Oruka Therapeutics (ORKA), representing 5.2% of the company’s common stock based on 60,312,101 Shares outstanding as of April 30, 2026.

How many Oruka Therapeutics (ORKA) shares are outstanding?

The filing states there are 60,312,101 Shares of Oruka Therapeutics common stock outstanding as of April 30, 2026, as reported in the company’s Quarterly Report on Form 10-Q filed on May 13, 2026.

Does RTW Investments have sole or shared voting power over ORKA shares?

RTW Investments and Roderick Wong report 0 Shares with sole voting power and 3,139,030 Shares with shared voting power, matching the number of shares with shared dispositive power over Oruka Therapeutics common stock.

Who actually receives dividends and sale proceeds from the ORKA shares?

The filing states that the RTW Funds have the right to receive, or direct the receipt of, dividends and proceeds from the sale of the 3,139,030 Shares reported as beneficially owned in Oruka Therapeutics.

How is beneficial ownership over ORKA shares characterized for RTW Investments and Roderick Wong?

RTW Investments and Roderick Wong are identified as Reporting Persons, but the filing states it should not be construed as an admission that any Reporting Person is the beneficial owner of the Oruka Therapeutics shares for Section 13 purposes.

What percentage of ORKA’s common stock class does each Reporting Person hold?

Both RTW Investments and Roderick Wong are listed with a 5.2% beneficial ownership of Oruka Therapeutics’ common stock class, based on 60,312,101 Shares outstanding as of April 30, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/14/2026 - 08:05 AM Accepted by SEC EDGAR 08/14/2026 - 08:04 AM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

ORUKA THERAPEUTICS, INC.

(Name of Issuer)

Common Stock, $0.001 par value

(Title of Class of Securities)

687604108

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 687604108

1

Names of Reporting Persons

RTW Investments, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 3,139,030.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 3,139,030.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,139,030.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.2 %

12

Type of Reporting Person (See Instructions)

IA, PN

SCHEDULE 13G

CUSIP Number(s): 687604108

1

Names of Reporting Persons

Roderick Wong

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 3,139,030.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 3,139,030.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,139,030.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.2 %

12

Type of Reporting Person (See Instructions)

HC, IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: ORUKA THERAPEUTICS, INC.
(b)	Address of issuer's principal executive offices: 855 Oak Grove Avenue, Suite 100, Menlo Park, CA, 94025 .
Item 2.
(a)	Name of person filing: This statement is filed by: (i) RTW Investments, LP ("RTW Investments"), a Delaware limited partnership and the investment adviser to certain funds (the "RTW Funds"), with respect to shares of Common Stock, par value $0.001 per share (the "Shares") of Oruka Therapeutics, Inc. (the "Company") directly held by the RTW Funds; and (ii) Roderick Wong, M.D. ("Dr. Wong"), the Managing Partner and Chief Investment Officer of RTW Investments, with respect to the Shares directly held by the RTW Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of the Shares reported herein.
(b)	Address or principal business office or, if none, residence: The address of the business office of each of the Reporting Persons is 40 10th Avenue, Floor 7, New York, New York 10014.
(c)	Citizenship: RTW Investments is a Delaware limited partnership. Dr. Wong is a citizen of the United States.
(d)	Title of class of securities: Common Stock, $0.001 par value
(e)	CUSIP Number(s): 687604108
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Rows 5 - 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentages set forth in Row 11 of the cover pages are calculated based upon 60,312,101 Shares outstanding as of April 30, 2026 as reported in the Company's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 13, 2026.
(b)	Percent of class: RTW Investments: 5.2% Dr. Wong: 5.2%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: RTW Investments: 0 Dr. Wong: 0
	(ii) Shared power to vote or to direct the vote: RTW Investments: 3,139,030 Shares Dr. Wong: 3,139,030 Shares
	(iii) Sole power to dispose or to direct the disposition of: RTW Investments: 0 Dr. Wong: 0
	(iv) Shared power to dispose or to direct the disposition of: RTW Investments: 3,139,030 Shares Dr. Wong: 3,139,030 Shares
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See Item 2. The RTW Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Shares reported herein.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

RTW Investments, LP

Signature:	/s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D., Managing Partner
Date:	08/14/2026

Roderick Wong

Signature:	/s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D.
Date:	08/14/2026

Exhibit Information

Exhibit 99.1 Joint Filing Agreement