Freenome 10% holders Perceptive and Edelman file Form 3

Freenome, Inc. reports that Perceptive Life Sciences Master Fund Ltd, Perceptive Advisors LLC and Joseph Edelman have filed an initial statement of beneficial ownership as 10% owners.

Rhea-AI Filing Summary

Freenome, Inc. reports that Perceptive Life Sciences Master Fund Ltd, Perceptive Advisors LLC and Joseph Edelman have filed an initial statement of beneficial ownership as 10% owners. The common stock reported corresponds to Legacy Freenome Series B, C, D and F preferred shares on an as-converted basis in connection with a business combination between Freenome Holdings, Inc. and Perceptive Capital Solutions Corp. under a Business Combination Agreement dated December 5, 2025. Perceptive Advisors and Mr. Edelman disclaim beneficial ownership beyond their indirect pecuniary interest.

Insider Trade Summary

4 transactions reported

Mixed 4 txns

Insider PERCEPTIVE ADVISORS LLC, PERCEPTIVE LIFE SCIENCES MASTER FUND LTD, EDELMAN JOSEPH

Role 10% Owner | 10% Owner | 10% Owner

Type	Security	Shares	Price	Value
holding	Common Stock F1, F2	--	--	--
holding	Common Stock F3, F2	--	--	--
holding	Common Stock F4, F2	--	--	--
holding	Common Stock F5, F2	--	--	--

Holdings After Transaction: Common Stock — 5,371,847 shares (Direct)

Footnotes (5)

1. F1. Represents shares of common stock of the Issuer corresponding to shares of Series B Preferred Stock of Freenome Holdings, Inc. held by the Reporting Persons, on an as-converted basis, in connection with the business combination between Freenome Holdings, Inc. and Perceptive Capital Solutions Corp. pursuant to the Business Combination Agreement, dated as of December 5, 2025 (the "Business Combination").
2. F2. The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of the Master Fund. Joseph Edelman ("Mr. Edelman") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman is a beneficial owner of such securities for purposes of Section 16 or for any other purpose.
3. F3. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series C Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.
4. F4. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series D Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.
5. F5. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series F Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.

Key Figures

Holding entries: 4 Reporting persons: 3 Business Combination Agreement date: December 5, 2025

3 metrics

Holding entries 4 Number of Common Stock holding rows reported in the Form 3

Reporting persons 3 Perceptive Advisors LLC, Perceptive Life Sciences Master Fund Ltd, Joseph Edelman

Business Combination Agreement date December 5, 2025 Date of agreement between Freenome Holdings, Inc. and Perceptive Capital Solutions Corp.

Key Terms

Business Combination Agreement, as-converted basis, beneficial ownership, pecuniary interest

4 terms

Business Combination Agreement regulatory

"pursuant to the Business Combination Agreement, dated as of December 5, 2025"

A business combination agreement is a detailed contract that lays out the terms for two companies to join together—covering price, how ownership will be split, the steps needed to close the deal, and what each side promises to do or avoid before closing. For investors it matters because the agreement determines potential changes in value, control, timing, and risk exposure—think of it like the playbook for a merger that shows who wins, who pays, and what could still derail the plan.

as-converted basis financial

"shares of common stock of the Issuer corresponding to shares ... on an as-converted basis"

As-converted basis means counting securities that can become common stock—like convertible bonds or preferred shares—as if they already were common shares when calculating totals such as shares outstanding, ownership percentages, or per-share metrics. Investors use it to see the potential dilution and the “what-if” size of the shareholder base; it’s like imagining all restaurant coupons have been redeemed so you know how crowded the table could become and how slices of the pie would shrink.

beneficial ownership regulatory

"disclaims, for purposes of Section 16 ... beneficial ownership of such securities"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

pecuniary interest financial

"except to the extent of their indirect pecuniary interest therein"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does the Form 3 related to PCSC and Freenome, Inc. disclose?

It discloses initial beneficial ownership of Freenome, Inc. common stock by Perceptive Life Sciences Master Fund, Perceptive Advisors and Joseph Edelman as 10% owners, tied to preferred shares converted in a business combination with Perceptive Capital Solutions Corp.

Who are the reporting persons in the PCSC/Freenome Form 3 filing?

The reporting persons are Perceptive Advisors LLC, Perceptive Life Sciences Master Fund Ltd, and Joseph Edelman. Each is identified as a 10% owner of Freenome, Inc. for Section 16 purposes in this initial ownership report.

How are Perceptive funds connected to Freenome, Inc. (PCSC context)?

The securities are directly held by Perceptive Life Sciences Master Fund Ltd, with Perceptive Advisors LLC as investment manager and Joseph Edelman as managing member. They report Freenome common stock corresponding to several Legacy Freenome preferred series on an as-converted basis.

What business combination is referenced in this PCSC-related ownership filing?

The Form 3 references a business combination between Freenome Holdings, Inc. and Perceptive Capital Solutions Corp. pursuant to a Business Combination Agreement dated December 5, 2025, with preferred shares converting into Freenome, Inc. common stock.

Do Perceptive Advisors and Joseph Edelman claim full beneficial ownership of FRNM shares?

No. A footnote states Perceptive Advisors and Joseph Edelman disclaim beneficial ownership of the reported securities for Section 16 purposes, except to the extent of their indirect pecuniary interest in the Master Fund’s holdings.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 07/22/2026 - 08:51 PM Accepted by SEC EDGAR 07/22/2026 - 08:50 PM Learn about SEC filing dates

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0104
Estimated average burden
hours per response:			0.5

1. Name and Address of Reporting Person^*

PERCEPTIVE ADVISORS LLC

(Last) (First) (Middle)

51 ASTOR PLACE, 10TH FLOOR

(Street)

NEW YORK NEW YORK 10003

(City) (State) (Zip)

UNITED STATES

(Country)

2. Date of Event Requiring Statement (Month/Day/Year)
07/20/2026

3. Issuer Name and Ticker or Trading Symbol
Freenome, Inc. [ FRNM ]

3a. Foreign Trading Symbol

5. If Amendment, Date of Original Filed (Month/Day/Year)

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	1,241,563(1)	D(2)
Common Stock	1,711,065(3)	D(2)
Common Stock	1,654,500(4)	D(2)
Common Stock	764,719(5)	D(2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

PERCEPTIVE ADVISORS LLC

(Last) (First) (Middle)

51 ASTOR PLACE, 10TH FLOOR

(Street)

NEW YORK NEW YORK 10003

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD

(Last) (First) (Middle)

51 ASTOR PLACE, 10TH FLOOR

(Street)

NEW YORK NEW YORK 10003

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

EDELMAN JOSEPH

(Last) (First) (Middle)

51 ASTOR PLACE, 10TH FLOOR

(Street)

NEW YORK NEW YORK 10003

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. Represents shares of common stock of the Issuer corresponding to shares of Series B Preferred Stock of Freenome Holdings, Inc. held by the Reporting Persons, on an as-converted basis, in connection with the business combination between Freenome Holdings, Inc. and Perceptive Capital Solutions Corp. pursuant to the Business Combination Agreement, dated as of December 5, 2025 (the "Business Combination").

2. The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of the Master Fund. Joseph Edelman ("Mr. Edelman") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman is a beneficial owner of such securities for purposes of Section 16 or for any other purpose.

3. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series C Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.

4. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series D Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.

5. Represents shares of common stock of the Issuer corresponding to shares of Legacy Freenome Series F Preferred Stock held by the Reporting Persons, on an as-converted basis, in connection with the Business Combination.

	/s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member	07/22/2026
	/s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member	07/22/2026
	/s/ Joseph Edelman	07/22/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 3: SEC 1473 (03-26)