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[Form 3] Praxis Precision Medicines, Inc. Initial Statement of Beneficial Ownership

Filing Impact
(Low)
Filing Sentiment
(Neutral)
Form Type
3
Rhea-AI Filing Summary

Adage Capital Management, L.P. reported an initial Section 16 filing for Praxis Precision Medicines, Inc. (PRAX) disclosing 2,374,085 shares beneficially owned indirectly. The filing states these shares are held directly by Adage Capital Partners, L.P. (ACP) and that Adage Capital Management, L.P. (ACM) serves as ACP's investment manager with discretionary authority over the portfolio. Robert Atchinson and Phillip Gross are identified as managing members of related Adage entities. The reporting persons are listed as Directors and as a 10% owner relationship to the issuer. The filing includes standard Section 16 disclaimers that each reporting person disclaims beneficial ownership except for any pecuniary interest, and it is signed by Adage and the two individuals on 08/19/2025.

Adage Capital Management, L.P. ha presentato un primo deposito ai sensi della Sezione 16 per Praxis Precision Medicines, Inc. (PRAX), dichiarando la titolarità beneficiaria indiretta di 2.374.085 azioni. Il deposito indica che queste azioni sono detenute direttamente da Adage Capital Partners, L.P. (ACP) e che Adage Capital Management, L.P. (ACM) agisce come gestore degli investimenti di ACP con autorità discrezionale sul portafoglio. Robert Atchinson e Phillip Gross sono indicati come membri gestori di entità correlate di Adage. Le persone che presentano la comunicazione sono elencate come Amministratori e come detentori di una quota del 10% rispetto all'emittente. Il documento contiene le consuete clausole di non responsabilità previste dalla Sezione 16, con ciascuna persona che rinuncia alla titolarità beneficiaria ad eccezione di eventuali interessi pecuniari, ed è firmato da Adage e dai due individui in data 08/19/2025.

Adage Capital Management, L.P. presentó una declaración inicial bajo la Sección 16 para Praxis Precision Medicines, Inc. (PRAX), informando la titularidad beneficiaria indirecta de 2.374.085 acciones. La presentación señala que dichas acciones están en poder directo de Adage Capital Partners, L.P. (ACP) y que Adage Capital Management, L.P. (ACM) actúa como gestor de inversiones de ACP con autoridad discrecional sobre la cartera. Robert Atchinson y Phillip Gross figuran como miembros gerentes de entidades relacionadas con Adage. Los informantes se listan como Directores y como propietarios del 10% respecto al emisor. El documento incluye las habituales renuncias de la Sección 16, indicando que cada informante renuncia a la titularidad beneficiaria salvo por cualquier interés pecuniario, y está firmado por Adage y las dos personas con fecha 08/19/2025.

Adage Capital Management, L.P.는 Praxis Precision Medicines, Inc.(PRAX)에 대한 섹션 16 초기 보고서를 제출했으며, 간접적으로 2,374,085주를 실질 보유하고 있음을 밝혔습니다. 제출서에는 해당 주식이 Adage Capital Partners, L.P.(ACP)에 의해 직접 보유되고 있으며 Adage Capital Management, L.P.(ACM)가 포트폴리오에 대한 재량권을 가진 ACP의 투자 관리자 역할을 한다고 기재되어 있습니다. Robert Atchinson과 Phillip Gross는 관련 Adage 계열사의 운영 멤버로 확인되었습니다. 보고인은 발행인에 대해 이사(Directors)10% 보유자 관계로 등재되어 있습니다. 제출서에는 섹션 16의 통상적인 고지(각 보고인은 금전적 이익을 제외한 실질적 소유권을 부인함)가 포함되어 있으며, Adage와 두 개인이 08/19/2025에 서명했습니다.

Adage Capital Management, L.P. a déposé une première déclaration au titre de la Section 16 pour Praxis Precision Medicines, Inc. (PRAX), indiquant la détention bénéficiaire indirecte de 2 374 085 actions. Le dépôt précise que ces actions sont détenues directement par Adage Capital Partners, L.P. (ACP) et qu'Adage Capital Management, L.P. (ACM) agit en tant que gestionnaire d'investissement d'ACP avec autorité discrétionnaire sur le portefeuille. Robert Atchinson et Phillip Gross sont identifiés comme membres dirigeants d'entités Adage apparentées. Les déclarants sont listés comme Administrateurs et comme détenteurs de 10% par rapport à l'émetteur. Le document comprend les clauses de non-responsabilité habituelles de la Section 16, chaque déclarant déclinant la qualité de propriétaire bénéficiaire sauf pour tout intérêt pécuniaire, et il est signé par Adage et les deux personnes le 08/19/2025.

Adage Capital Management, L.P. reichte eine erste Meldung nach Section 16 für Praxis Precision Medicines, Inc. (PRAX) ein und gab an, indirekt 2.374.085 Aktien wirtschaftlich zu besitzen. In der Meldung heißt es, dass diese Aktien direkt von Adage Capital Partners, L.P. (ACP) gehalten werden und dass Adage Capital Management, L.P. (ACM) als Investmentmanager von ACP mit diskretionärer Befugnis über das Portfolio fungiert. Robert Atchinson und Phillip Gross werden als geschäftsführende Mitglieder verwandter Adage-Gesellschaften genannt. Die Meldenden sind als Directors und als 10%-Eigentümer in Bezug auf den Emittenten aufgeführt. Die Einreichung enthält die üblichen Section-16-Haftungsausschlüsse, wonach jede meldende Person das wirtschaftliche Eigentum mit Ausnahme etwaiger pecuniärer Interessen bestreitet, und sie ist von Adage und den beiden Personen am 08/19/2025 unterzeichnet.

Positive
  • Initial public disclosure of an indirect stake of 2,374,085 shares in PRAX, improving transparency
  • Complete chain of ownership identified: securities held by Adage Capital Partners, L.P., managed by Adage Capital Management, L.P.
  • Named reporting persons (Robert Atchinson and Phillip Gross) with signatures, meeting Section 16 filing formalities
Negative
  • None.

Insights

TL;DR: Routine Section 16 initial disclosure showing an indirect position of 2,374,085 shares held through Adage entities; compliance filing appears complete.

The Form 3 documents an initial beneficial-ownership disclosure for PRAX where the economic interest is held by Adage Capital Partners, L.P., with Adage Capital Management, L.P. acting as investment manager. The filing identifies two individuals, Robert Atchinson and Phillip Gross, connected via managerial roles in the relevant Adage entities, and marks the relationship as Director and 10% owner. It includes the customary disclaimer of beneficial ownership and is signed and dated. From a compliance perspective, the filing supplies the required ownership amount, ownership form (indirect), reporting persons, and signatures, satisfying basic Section 16 initial-statement elements.

TL;DR: Disclosure provides transparency on a sizable indirect stake of 2,374,085 PRAX shares by Adage-affiliated entities.

The filing clarifies the chain of ownership: ACP holds the shares directly while ACM manages ACP's portfolio, and two named managers link the governance structure. This provides investors and the issuer with clear identification of a significant holder and the responsible reporting parties. The standard pecuniary-interest disclaimer is present. No transactions, derivative positions, or changes in holdings are reported here—this is an initial ownership statement rather than an event-driven trade disclosure.

Adage Capital Management, L.P. ha presentato un primo deposito ai sensi della Sezione 16 per Praxis Precision Medicines, Inc. (PRAX), dichiarando la titolarità beneficiaria indiretta di 2.374.085 azioni. Il deposito indica che queste azioni sono detenute direttamente da Adage Capital Partners, L.P. (ACP) e che Adage Capital Management, L.P. (ACM) agisce come gestore degli investimenti di ACP con autorità discrezionale sul portafoglio. Robert Atchinson e Phillip Gross sono indicati come membri gestori di entità correlate di Adage. Le persone che presentano la comunicazione sono elencate come Amministratori e come detentori di una quota del 10% rispetto all'emittente. Il documento contiene le consuete clausole di non responsabilità previste dalla Sezione 16, con ciascuna persona che rinuncia alla titolarità beneficiaria ad eccezione di eventuali interessi pecuniari, ed è firmato da Adage e dai due individui in data 08/19/2025.

Adage Capital Management, L.P. presentó una declaración inicial bajo la Sección 16 para Praxis Precision Medicines, Inc. (PRAX), informando la titularidad beneficiaria indirecta de 2.374.085 acciones. La presentación señala que dichas acciones están en poder directo de Adage Capital Partners, L.P. (ACP) y que Adage Capital Management, L.P. (ACM) actúa como gestor de inversiones de ACP con autoridad discrecional sobre la cartera. Robert Atchinson y Phillip Gross figuran como miembros gerentes de entidades relacionadas con Adage. Los informantes se listan como Directores y como propietarios del 10% respecto al emisor. El documento incluye las habituales renuncias de la Sección 16, indicando que cada informante renuncia a la titularidad beneficiaria salvo por cualquier interés pecuniario, y está firmado por Adage y las dos personas con fecha 08/19/2025.

Adage Capital Management, L.P.는 Praxis Precision Medicines, Inc.(PRAX)에 대한 섹션 16 초기 보고서를 제출했으며, 간접적으로 2,374,085주를 실질 보유하고 있음을 밝혔습니다. 제출서에는 해당 주식이 Adage Capital Partners, L.P.(ACP)에 의해 직접 보유되고 있으며 Adage Capital Management, L.P.(ACM)가 포트폴리오에 대한 재량권을 가진 ACP의 투자 관리자 역할을 한다고 기재되어 있습니다. Robert Atchinson과 Phillip Gross는 관련 Adage 계열사의 운영 멤버로 확인되었습니다. 보고인은 발행인에 대해 이사(Directors)10% 보유자 관계로 등재되어 있습니다. 제출서에는 섹션 16의 통상적인 고지(각 보고인은 금전적 이익을 제외한 실질적 소유권을 부인함)가 포함되어 있으며, Adage와 두 개인이 08/19/2025에 서명했습니다.

Adage Capital Management, L.P. a déposé une première déclaration au titre de la Section 16 pour Praxis Precision Medicines, Inc. (PRAX), indiquant la détention bénéficiaire indirecte de 2 374 085 actions. Le dépôt précise que ces actions sont détenues directement par Adage Capital Partners, L.P. (ACP) et qu'Adage Capital Management, L.P. (ACM) agit en tant que gestionnaire d'investissement d'ACP avec autorité discrétionnaire sur le portefeuille. Robert Atchinson et Phillip Gross sont identifiés comme membres dirigeants d'entités Adage apparentées. Les déclarants sont listés comme Administrateurs et comme détenteurs de 10% par rapport à l'émetteur. Le document comprend les clauses de non-responsabilité habituelles de la Section 16, chaque déclarant déclinant la qualité de propriétaire bénéficiaire sauf pour tout intérêt pécuniaire, et il est signé par Adage et les deux personnes le 08/19/2025.

Adage Capital Management, L.P. reichte eine erste Meldung nach Section 16 für Praxis Precision Medicines, Inc. (PRAX) ein und gab an, indirekt 2.374.085 Aktien wirtschaftlich zu besitzen. In der Meldung heißt es, dass diese Aktien direkt von Adage Capital Partners, L.P. (ACP) gehalten werden und dass Adage Capital Management, L.P. (ACM) als Investmentmanager von ACP mit diskretionärer Befugnis über das Portfolio fungiert. Robert Atchinson und Phillip Gross werden als geschäftsführende Mitglieder verwandter Adage-Gesellschaften genannt. Die Meldenden sind als Directors und als 10%-Eigentümer in Bezug auf den Emittenten aufgeführt. Die Einreichung enthält die üblichen Section-16-Haftungsausschlüsse, wonach jede meldende Person das wirtschaftliche Eigentum mit Ausnahme etwaiger pecuniärer Interessen bestreitet, und sie ist von Adage und den beiden Personen am 08/19/2025 unterzeichnet.

SEC Form 3
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Adage Capital Management, L.P.

(Last) (First) (Middle)
200 CLARENDON STREET, 52ND FLOOR

(Street)
BOSTON MA 02116

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
08/18/2025
3. Issuer Name and Ticker or Trading Symbol
Praxis Precision Medicines, Inc. [ PRAX ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Title of Security (Instr. 4) 2,374,085 I See footnotes(1)(2)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
1. Name and Address of Reporting Person*
Adage Capital Management, L.P.

(Last) (First) (Middle)
200 CLARENDON STREET, 52ND FLOOR

(Street)
BOSTON MA 02116

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer
Director X 10% Owner
Officer (give title below) Other (specify below)
1. Name and Address of Reporting Person*
Atchinson Robert

(Last) (First) (Middle)
200 CLARENDON STREET
52ND FLOOR

(Street)
BOSTON MA 02116

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer
Director X 10% Owner
Officer (give title below) Other (specify below)
1. Name and Address of Reporting Person*
Gross Phillip

(Last) (First) (Middle)
200 CLARENDON STREET
52ND FLOOR

(Street)
BOSTON MA 02116

(City) (State) (Zip)

Relationship of Reporting Person(s) to Issuer
Director X 10% Owner
Officer (give title below) Other (specify below)
Explanation of Responses:
1. The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership ("ACP"). Adage Capital Management, L.P., a Delaware limited partnership ("ACM"), serves as the investment manager of ACP and as such has discretion over the portfolio securities held by ACP. Robert Atchinson and Phillip Gross are the managing members of (i) Adage Capital Advisors, L.L.C., a Delaware limited liability company, managing member of Adage Capital Partners GP, L.L.C., a Delaware limited liability company, general partner of ACP and (ii) Adage Capital Partners LLC, a Delaware limited liability company, general partner of ACM.
2. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities, if any.
/s/ Adage Capital Management, L.P.; By: its general partner Adage Capital Partners LLC; By its managing member Robert Atchinson 08/19/2025
/s/ Robert Atchinson 08/19/2025
/s/ Phillip Gross 08/19/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What number of PRAX shares does Adage report owning?

The filing reports 2,374,085 shares beneficially owned indirectly.

Who holds the PRAX shares according to the Form 3?

The shares are held directly by Adage Capital Partners, L.P. with Adage Capital Management, L.P. acting as investment manager.

Which individuals are named as reporting persons on the Form 3?

The filing names Robert Atchinson and Phillip Gross as reporting persons and managing members of related Adage entities.

How did the filing describe the reporters' relationship to PRAX?

Each reporting person is indicated as a Director and as a 10% owner in relation to the issuer.

When was the event requiring this Form 3 reported?

The Date of Event Requiring Statement is listed as 08/18/2025, and the form is signed on 08/19/2025.
Praxis Precision Medicines, Inc.

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Biotechnology
Pharmaceutical Preparations
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United States
BOSTON