Vanguard (NASDAQ: PRAX) reports 1.42M shares, 5.09% stake in Praxis

Rhea-AI Filing Summary

Praxis Precision Medicines Inc ownership filing shows 1,419,323 shares of Common Stock reported by Vanguard Capital Management, representing 5.09% of the class. The filing lists 197,379 shares as sole voting power and 1,419,323 as sole dispositive power. The filing notes that this ownership "reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Capital Management LLC and the following affiliates..."

Insights

Institutional Ownership Analyst

Large passive stake disclosed: 1.42M shares (5.09%).

Vanguard Capital Management reports beneficial ownership of 1,419,323 shares, equal to 5.09% of Praxis Precision Medicines common stock. The filing itemizes voting and dispositive powers, showing Vanguard holds sole dispositive authority for all reported shares.

Implications depend on Vanguard's voting behavior; subsequent filings or proxy statements would reveal whether this stake influences governance.

Regulatory Compliance Expert

Schedule 13G disclosure completed with affiliate attribution.

The statement includes the SEC Release No. 34-39538 disclosure language attributing holdings across Vanguard affiliates and funds. The signature block shows the filing was signed by Ashley Grim as Head of Global Fund Administration on 04/30/2026.

Filing appears to follow required Schedule 13G identification and ownership fields; any change in ownership above reporting thresholds would trigger an amended filing.

Key Figures

Shares reported beneficially owned: 1,419,323 shares Percent of class: 5.09% Sole voting power: 197,379 shares +2 more

5 metrics

Shares reported beneficially owned 1,419,323 shares Schedule 13G beneficial ownership reported

Percent of class 5.09% Percent of common stock reported

Sole voting power 197,379 shares Number with sole power to vote

Sole dispositive power 1,419,323 shares Number with sole power to dispose

CUSIP 74006W207 Praxis Precision Medicines common stock identifier

Key Terms

Schedule 13G, sole dispositive power, beneficially owned

3 terms

Schedule 13G regulatory

"Item 1. | (a) | Name of issuer: Praxis Precision Medicines Inc"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

sole dispositive power financial

"Item 4. | (c) | (iii) Sole power to dispose or to direct the disposition of: 1419323"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

beneficially owned regulatory

"This reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Capital Management LLC"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Praxis Precision Medicines Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

74006W207

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 74006W207

1

Names of Reporting Persons

Vanguard Capital Management

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 197,379.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 1,419,323.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

1,419,323.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.09 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Capital Management LLC and the following affiliates of Vanguard Capital Management LLC or business divisions of such affiliates: Vanguard Asset Management Limited, Vanguard Fiduciary Trust Company, Vanguard Global Advisers, LLC and Vanguard Investments Australia Ltd. This Schedule 13G includes securities held by Vanguard funds, or sleeves thereof, over which Vanguard Capital Management LLC exercises dispositive power, in addition to securities held by clients over which the affiliates or business divisions of such affiliates indicated above exercise dispositive and/or voting power. This Schedule 13G does not include securities, if any, beneficially owned by other subsidiaries or affiliates of Vanguard Capital Management LLC, or business divisions of such subsidiaries, whose ownership of securities is disaggregated from that of the reporting business unit in accordance with such release.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Praxis Precision Medicines Inc
(b)	Address of issuer's principal executive offices: 99 High Street, 30th Floor, Boston, MA, 02110
Item 2.
(a)	Name of person filing: Vanguard Capital Management
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP Number(s): 74006W207
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 1419323
(b)	Percent of class: 5.09 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 197379
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 1419323
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Vanguard Capital Management, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Vanguard Capital Management

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	04/30/2026

FAQ

What stake does Vanguard Capital Management report in PRAX?

Vanguard reports beneficial ownership of 1,419,323 shares of PRAX common stock, representing 5.09% of the class. The filing shows sole dispositive power over all 1,419,323 shares and sole voting power for 197,379 shares.

Who signed the Schedule 13G for PRAX on behalf of Vanguard?

Ashley Grim, Head of Global Fund Administration, signed the Schedule 13G. The signature block in the filing is dated 04/30/2026, attesting to the reported ownership information.

Does Vanguard report voting and dispositive power for the shares in PRAX?

Yes. The filing lists 197,379 shares as sole voting power and 1,419,323 shares as sole dispositive power. Shared voting and dispositive power are reported as 0 in the filing.

Are the reported PRAX shares held through Vanguard affiliates or funds?

The filing states the amount "reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Capital Management LLC and the following affiliates," including Vanguard funds and specified business divisions that exercise dispositive or voting power.

Does any other person hold more than 5% of PRAX according to this filing?

The filing states that no one other person's interest in the securities reported herein is more than 5%. Vanguard Capital Management reports the only >5% stake shown in this disclosure.