STOCK TITAN

[Form 4] Prime Medicine, Inc. Insider Trading Activity

Filing Impact
(High)
Filing Sentiment
(Very Positive)
Form Type
4
Rhea-AI Filing Summary

On 31-Jul-2025, Michelle K. Lewis, CFO of subsidiary AAA Cooper Transportation, filed a Form 4 for Knight-Swift Transportation (KNX). She exercised 503 restricted stock units (code M), converting them one-for-one into Class A common shares. Immediately thereafter, 148 shares were withheld at $42.50 (code F) to satisfy tax obligations, a routine transaction.

Following the two entries, Lewis’ direct ownership rose to 3,611 shares. The RSUs stem from a 2021 grant that vests in five equal tranches beginning 31-Jul-2022. No derivatives remain outstanding from this grant after the conversion.

The filing signals that the insider retained ~70% of the vested shares (355 net), suggesting continued alignment with shareholders, though the dollar value (~$15 k) is immaterial to KNX’s $7 bn market cap. Investors typically view net insider accumulation as a modestly constructive signal; however, the scale and routine nature limit market impact.

Il 31-lug-2025, Michelle K. Lewis, CFO della controllata AAA Cooper Transportation, ha presentato un Modulo 4 per Knight-Swift Transportation (KNX). Ha esercitato 503 unità azionarie vincolate (codice M), convertendole una a una in azioni ordinarie di Classe A. Immediatamente dopo, sono state trattenute 148 azioni a 42,50 $ (codice F) per soddisfare obblighi fiscali, una transazione di routine.

In seguito a queste due operazioni, la detenzione diretta di Lewis è salita a 3.611 azioni. Le RSU derivano da una concessione del 2021 che matura in cinque tranche uguali a partire dal 31-lug-2022. Dopo la conversione, non rimangono derivati in sospeso da questa concessione.

La comunicazione indica che l’insider ha mantenuto circa il 70% delle azioni maturate (355 nette), suggerendo un allineamento continuo con gli azionisti, anche se il valore in dollari (~15 mila $) è irrilevante rispetto alla capitalizzazione di mercato di KNX di 7 miliardi di $. Gli investitori generalmente interpretano l’accumulo netto da parte degli insider come un segnale moderatamente positivo; tuttavia, la portata e la natura routinaria limitano l’impatto sul mercato.

El 31-jul-2025, Michelle K. Lewis, CFO de la filial AAA Cooper Transportation, presentó un Formulario 4 para Knight-Swift Transportation (KNX). Ella ejerció 503 unidades de acciones restringidas (código M), convirtiéndolas una a una en acciones ordinarias Clase A. Inmediatamente después, se retuvieron 148 acciones a $42.50 (código F) para cumplir con obligaciones fiscales, una transacción rutinaria.

Tras estas dos anotaciones, la propiedad directa de Lewis aumentó a 3,611 acciones. Las RSU provienen de una concesión de 2021 que se consolida en cinco tramos iguales desde el 31-jul-2022. Después de la conversión, no quedan derivados pendientes de esta concesión.

La presentación indica que la persona con información privilegiada retuvo aproximadamente el 70% de las acciones consolidadas (355 netas), sugiriendo una alineación continua con los accionistas, aunque el valor en dólares (~15 mil) es insignificante en comparación con la capitalización de mercado de KNX de 7 mil millones de dólares. Los inversores suelen ver la acumulación neta de insiders como una señal moderadamente positiva; sin embargo, la escala y la naturaleza rutinaria limitan el impacto en el mercado.

2025년 7월 31일, 자회사 AAA Cooper Transportation의 CFO인 Michelle K. Lewis가 Knight-Swift Transportation (KNX)에 대해 Form 4를 제출했습니다. 그녀는 503개의 제한 주식 단위(코드 M)를 행사하여 이를 1대 1 비율로 클래스 A 보통주로 전환했습니다. 그 직후 148주가 $42.50(코드 F)에 원천징수되어 세금 의무를 충족했습니다, 이는 일상적인 거래입니다.

이 두 건의 거래 후 Lewis의 직접 보유 주식 수는 3,611주로 증가했습니다. 이 RSU는 2021년 부여된 것으로, 2022년 7월 31일부터 5개의 동일한 분할로 베스팅됩니다. 전환 후에는 이 부여에서 남은 파생상품이 없습니다.

이번 신고는 내부자가 베스팅된 주식의 약 70% (순 355주)를 보유하고 있음을 나타내며, 주주들과의 지속적인 이해관계 일치를 시사합니다. 다만 금액(~$15,000)은 KNX의 70억 달러 시가총액에 비해 미미합니다. 투자자들은 일반적으로 내부자의 순매수를 다소 긍정적인 신호로 보지만, 규모와 일상적인 성격 때문에 시장 영향은 제한적입니다.

Le 31 juil. 2025, Michelle K. Lewis, CFO de la filiale AAA Cooper Transportation, a déposé un formulaire 4 pour Knight-Swift Transportation (KNX). Elle a exercé 503 unités d’actions restreintes (code M), les convertissant une à une en actions ordinaires de classe A. Immédiatement après, 148 actions ont été retenues à 42,50 $ (code F) pour satisfaire aux obligations fiscales, une opération de routine.

Après ces deux opérations, la détention directe de Lewis est passée à 3 611 actions. Les RSU proviennent d’une attribution de 2021 qui se libère en cinq tranches égales à partir du 31 juil. 2022. Aucun dérivé ne reste en circulation suite à cette conversion.

Le dépôt indique que l’initiée a conservé environ 70 % des actions acquises (355 nettes), suggérant un alignement continu avec les actionnaires, bien que la valeur en dollars (~15 k$) soit négligeable par rapport à la capitalisation boursière de KNX de 7 milliards de dollars. Les investisseurs considèrent généralement l’accumulation nette des initiés comme un signal modérément positif ; cependant, l’échelle et la nature routinière limitent l’impact sur le marché.

Am 31. Juli 2025 reichte Michelle K. Lewis, CFO der Tochtergesellschaft AAA Cooper Transportation, ein Formular 4 für Knight-Swift Transportation (KNX) ein. Sie übte 503 eingeschränkte Aktieneinheiten (Code M) aus und wandelte diese eins zu eins in Stammaktien der Klasse A um. Unmittelbar danach wurden 148 Aktien zu 42,50 $ (Code F) einbehalten, um Steuerverpflichtungen zu erfüllen – eine Routine-Transaktion.

Nach diesen beiden Buchungen stieg Lewis’ direkter Besitz auf 3.611 Aktien. Die RSUs stammen aus einer Zuteilung von 2021, die in fünf gleichen Tranchen ab dem 31. Juli 2022 vestet. Nach der Umwandlung sind keine Derivate aus dieser Zuteilung mehr ausstehend.

Die Meldung zeigt, dass der Insider etwa 70 % der vested Aktien (355 netto) behalten hat, was auf eine fortgesetzte Ausrichtung mit den Aktionären hindeutet, obwohl der Dollarwert (~15.000 $) im Vergleich zur Marktkapitalisierung von KNX von 7 Mrd. $ unerheblich ist. Investoren sehen Netto-Inhaberakkumulationen typischerweise als leicht positives Signal; die Größenordnung und routinemäßige Natur begrenzen jedoch die Marktauswirkungen.

Positive
  • None.
Negative
  • None.

Insights

TL;DR: Small net insider buy via RSU vesting; routine tax sale; negligible impact on KNX valuation.

The Form 4 shows Lewis converted 503 RSUs and retained 355 shares after paying taxes. Because RSU vesting is scheduled and the withheld shares equal roughly 30% of the gross amount—consistent with statutory tax rates—the activity appears planned rather than opportunistic. Insider retention is directionally positive but the absolute value (≈$15k) is far too small to influence supply-demand dynamics or signal a shift in corporate outlook. I assign a neutral impact rating.

Il 31-lug-2025, Michelle K. Lewis, CFO della controllata AAA Cooper Transportation, ha presentato un Modulo 4 per Knight-Swift Transportation (KNX). Ha esercitato 503 unità azionarie vincolate (codice M), convertendole una a una in azioni ordinarie di Classe A. Immediatamente dopo, sono state trattenute 148 azioni a 42,50 $ (codice F) per soddisfare obblighi fiscali, una transazione di routine.

In seguito a queste due operazioni, la detenzione diretta di Lewis è salita a 3.611 azioni. Le RSU derivano da una concessione del 2021 che matura in cinque tranche uguali a partire dal 31-lug-2022. Dopo la conversione, non rimangono derivati in sospeso da questa concessione.

La comunicazione indica che l’insider ha mantenuto circa il 70% delle azioni maturate (355 nette), suggerendo un allineamento continuo con gli azionisti, anche se il valore in dollari (~15 mila $) è irrilevante rispetto alla capitalizzazione di mercato di KNX di 7 miliardi di $. Gli investitori generalmente interpretano l’accumulo netto da parte degli insider come un segnale moderatamente positivo; tuttavia, la portata e la natura routinaria limitano l’impatto sul mercato.

El 31-jul-2025, Michelle K. Lewis, CFO de la filial AAA Cooper Transportation, presentó un Formulario 4 para Knight-Swift Transportation (KNX). Ella ejerció 503 unidades de acciones restringidas (código M), convirtiéndolas una a una en acciones ordinarias Clase A. Inmediatamente después, se retuvieron 148 acciones a $42.50 (código F) para cumplir con obligaciones fiscales, una transacción rutinaria.

Tras estas dos anotaciones, la propiedad directa de Lewis aumentó a 3,611 acciones. Las RSU provienen de una concesión de 2021 que se consolida en cinco tramos iguales desde el 31-jul-2022. Después de la conversión, no quedan derivados pendientes de esta concesión.

La presentación indica que la persona con información privilegiada retuvo aproximadamente el 70% de las acciones consolidadas (355 netas), sugiriendo una alineación continua con los accionistas, aunque el valor en dólares (~15 mil) es insignificante en comparación con la capitalización de mercado de KNX de 7 mil millones de dólares. Los inversores suelen ver la acumulación neta de insiders como una señal moderadamente positiva; sin embargo, la escala y la naturaleza rutinaria limitan el impacto en el mercado.

2025년 7월 31일, 자회사 AAA Cooper Transportation의 CFO인 Michelle K. Lewis가 Knight-Swift Transportation (KNX)에 대해 Form 4를 제출했습니다. 그녀는 503개의 제한 주식 단위(코드 M)를 행사하여 이를 1대 1 비율로 클래스 A 보통주로 전환했습니다. 그 직후 148주가 $42.50(코드 F)에 원천징수되어 세금 의무를 충족했습니다, 이는 일상적인 거래입니다.

이 두 건의 거래 후 Lewis의 직접 보유 주식 수는 3,611주로 증가했습니다. 이 RSU는 2021년 부여된 것으로, 2022년 7월 31일부터 5개의 동일한 분할로 베스팅됩니다. 전환 후에는 이 부여에서 남은 파생상품이 없습니다.

이번 신고는 내부자가 베스팅된 주식의 약 70% (순 355주)를 보유하고 있음을 나타내며, 주주들과의 지속적인 이해관계 일치를 시사합니다. 다만 금액(~$15,000)은 KNX의 70억 달러 시가총액에 비해 미미합니다. 투자자들은 일반적으로 내부자의 순매수를 다소 긍정적인 신호로 보지만, 규모와 일상적인 성격 때문에 시장 영향은 제한적입니다.

Le 31 juil. 2025, Michelle K. Lewis, CFO de la filiale AAA Cooper Transportation, a déposé un formulaire 4 pour Knight-Swift Transportation (KNX). Elle a exercé 503 unités d’actions restreintes (code M), les convertissant une à une en actions ordinaires de classe A. Immédiatement après, 148 actions ont été retenues à 42,50 $ (code F) pour satisfaire aux obligations fiscales, une opération de routine.

Après ces deux opérations, la détention directe de Lewis est passée à 3 611 actions. Les RSU proviennent d’une attribution de 2021 qui se libère en cinq tranches égales à partir du 31 juil. 2022. Aucun dérivé ne reste en circulation suite à cette conversion.

Le dépôt indique que l’initiée a conservé environ 70 % des actions acquises (355 nettes), suggérant un alignement continu avec les actionnaires, bien que la valeur en dollars (~15 k$) soit négligeable par rapport à la capitalisation boursière de KNX de 7 milliards de dollars. Les investisseurs considèrent généralement l’accumulation nette des initiés comme un signal modérément positif ; cependant, l’échelle et la nature routinière limitent l’impact sur le marché.

Am 31. Juli 2025 reichte Michelle K. Lewis, CFO der Tochtergesellschaft AAA Cooper Transportation, ein Formular 4 für Knight-Swift Transportation (KNX) ein. Sie übte 503 eingeschränkte Aktieneinheiten (Code M) aus und wandelte diese eins zu eins in Stammaktien der Klasse A um. Unmittelbar danach wurden 148 Aktien zu 42,50 $ (Code F) einbehalten, um Steuerverpflichtungen zu erfüllen – eine Routine-Transaktion.

Nach diesen beiden Buchungen stieg Lewis’ direkter Besitz auf 3.611 Aktien. Die RSUs stammen aus einer Zuteilung von 2021, die in fünf gleichen Tranchen ab dem 31. Juli 2022 vestet. Nach der Umwandlung sind keine Derivate aus dieser Zuteilung mehr ausstehend.

Die Meldung zeigt, dass der Insider etwa 70 % der vested Aktien (355 netto) behalten hat, was auf eine fortgesetzte Ausrichtung mit den Aktionären hindeutet, obwohl der Dollarwert (~15.000 $) im Vergleich zur Marktkapitalisierung von KNX von 7 Mrd. $ unerheblich ist. Investoren sehen Netto-Inhaberakkumulationen typischerweise als leicht positives Signal; die Größenordnung und routinemäßige Natur begrenzen jedoch die Marktauswirkungen.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
NELSEN ROBERT

(Last) (First) (Middle)
8755 W. HIGGINS ROAD, SUITE 1025

(Street)
CHICAGO IL 60631

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Prime Medicine, Inc. [ PRME ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
08/01/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 6,128,297 I By ARCH Venture Fund X, L.P.(1)(3)(4)
Common Stock 6,128,297 I By ARCH Venture Fund X Overage, L.P.(2)(3)(4)
Common Stock 08/01/2025 P 3,030,300 A $3.3 6,230,300 I By ARCH Venture Fund XII, L.P.(5)(6)
Common Stock 16,080 I See Footnote(7)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. Represents shares held directly by ARCH Venture Fund X, L.P. ("ARCH X"). ARCH Venture Partners X, L.P. ("AVP X LP") is the sole general partner of ARCH X.
2. Represents shares held directly by ARCH Venture Fund X Overage, L.P. ("ARCH X Overage"). ARCH Venture Partners X Overage, L.P. ("AVP X Overage LP") is the sole general partner of ARCH X Overage.
3. ARCH Venture Partners X, LLC ("AVP X LLC") is the sole general partner of each of AVP X LP and AVP X Overage LP. In addition to the Reporting Person, Keith Crandell, Kristina Burow and Steve Gillis are also members of the investment committee of AVP X LLC (the "AVP X Investment Committee Members"). AVP X LP and AVP X Overage LP may be deemed to beneficially own the shares held by ARCH X and ARCH X Overage, respectively, AVP X LLC may be deemed to beneficially own the shares held by ARCH X and ARCH X Overage, and each of the AVP X Investment Committee Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH X and ARCH X Overage. AVP X LP, AVP X Overage LP, AVP X LLC, and the other AVP X Investment Committee Members have filed a separate Form 4 and disclaim beneficial ownership except to the extent of any pecuniary interest therein.
4. The Reporting Person is also an AVP X Investment Committee Member and may be deemed to share the power to direct the disposition and vote of own the shares held by ARCH X and ARCH X Overage. The Reporting Person disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
5. Represents shares held directly by ARCH Venture Fund XII, L.P. ("ARCH XII"). ARCH Venture Partners XII, L.P. ("AVP XII LP") is the general partner of ARCH XII. ARCH Venture Partners XII, LLC (AVP XII LLC) is the general partner of AVP XII LP. In addition to the Reporting Person, Keith Crandell, Kristina Burow and Steven Gillis are also members of the investment committee of AVP XII LLC (the "AVP XII LLC Investment Committee Members"). Each of AVP XII LP and AVP XII LLC may be deemed to beneficially own the shares held by ARCH XII, and each of the AVP XII LLC Investment Committee Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH XII. Each of AVP XII LP, AVP XII LLC and the other AVP XII LLC Investment Committee Members have filed a separate Form 4 and disclaim beneficial ownership except to the extent of their pecuniary interest therein, if any.
6. The Reporting Person is also an AVP XII Investment Committee Member and may be deemed to to share the power to direct the disposition and vote of the shares held by ARCH XII. The Reporting Person disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that such shares are beneficially owned by him for Section 16 or any other purpose.
7. Shares held by a trust for the benefit of family members of the Reporting Person.
Robert Nelsen /s/ Mark McDonnell, attorney-in-fact 08/01/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
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Biotechnology
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