STOCK TITAN

[Form 4] Prime Medicine, Inc. Insider Trading Activity

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4
Rhea-AI Filing Summary

Prime Medicine, Inc. (PRME) – Form 4 insider transaction

Director and 10% owner David R. Liu disclosed the purchase of 21,000 shares of Prime Medicine common stock on 23-Jun-2025. The trade was executed under a previously adopted Rule 10b5-1 plan dated 3-Mar-2025, indicating it was pre-scheduled rather than opportunistic.

The weighted-average purchase price was $2.162 per share, with individual trades occurring between $2.06 – $2.25. Following the transaction, Liu’s direct ownership increased to 20,219,945 shares, an incremental addition of roughly 0.10 % to his existing stake.

No derivative securities were reported, and no sales occurred. While the absolute dollar value of the purchase (~$45,400) is modest relative to Liu’s overall holding, insider buying—especially by a high-ownership director—can be interpreted as a vote of confidence in the company’s prospects at current price levels.

Prime Medicine, Inc. (PRME) – Transazione interna Form 4

Il direttore e proprietario del 10% David R. Liu ha comunicato l'acquisto di 21.000 azioni ordinarie di Prime Medicine il 23 giugno 2025. L'operazione è stata eseguita nell'ambito di un piano Rule 10b5-1 precedentemente adottato il 3 marzo 2025, indicando che si trattava di un acquisto programmato e non opportunistico.

Il prezzo medio ponderato di acquisto è stato di 2,162 $ per azione, con singole transazioni comprese tra 2,06 $ e 2,25 $. Dopo l'operazione, la partecipazione diretta di Liu è salita a 20.219.945 azioni, con un incremento di circa 0,10% rispetto alla sua quota precedente.

Non sono stati segnalati strumenti derivati né vendite. Sebbene il valore assoluto dell'acquisto (~45.400 $) sia modesto rispetto alla partecipazione complessiva di Liu, l'acquisto da parte di un insider, in particolare di un direttore con elevata quota, può essere interpretato come un segnale di fiducia nelle prospettive dell'azienda ai livelli di prezzo attuali.

Prime Medicine, Inc. (PRME) – Transacción interna Formulario 4

El director y propietario del 10% David R. Liu informó la compra de 21,000 acciones ordinarias de Prime Medicine el 23 de junio de 2025. La operación se realizó bajo un plan Rule 10b5-1 adoptado previamente el 3 de marzo de 2025, lo que indica que fue programada con anticipación y no oportunista.

El precio promedio ponderado de compra fue de $2.162 por acción, con transacciones individuales entre $2.06 y $2.25. Tras la operación, la propiedad directa de Liu aumentó a 20,219,945 acciones, sumando aproximadamente un 0.10% a su participación previa.

No se reportaron valores derivados ni ventas. Aunque el valor absoluto de la compra (~$45,400) es modesto en relación con la participación total de Liu, la compra por parte de un insider, especialmente un director con alta participación, puede interpretarse como una señal de confianza en las perspectivas de la compañía a los niveles de precio actuales.

Prime Medicine, Inc. (PRME) – Form 4 내부자 거래

이사이자 10% 지분 보유자인 David R. Liu2025년 6월 23일에 Prime Medicine 보통주 21,000주를 매수했다고 공시했습니다. 이 거래는 2025년 3월 3일에 채택된 Rule 10b5-1 계획에 따라 사전에 예약된 거래임을 나타냅니다.

주당 가중평균 매입가는 $2.162였으며, 개별 거래 가격은 $2.06에서 $2.25 사이였습니다. 거래 후 Liu의 직접 보유 주식은 20,219,945주로 약 0.10% 증가했습니다.

파생상품은 보고되지 않았고 매도도 없었습니다. 매수 금액(~$45,400)은 Liu의 전체 보유 지분에 비해 적은 편이지만, 특히 고지분 이사의 내부자 매수는 현재 가격 수준에서 회사의 전망에 대한 신뢰의 표시로 해석될 수 있습니다.

Prime Medicine, Inc. (PRME) – Transaction d’initié Formulaire 4

Le directeur et détenteur de 10 % David R. Liu a déclaré l’achat de 21 000 actions ordinaires de Prime Medicine le 23 juin 2025. La transaction a été réalisée dans le cadre d’un plan Rule 10b5-1 adopté le 3 mars 2025, indiquant qu’elle était programmée à l’avance et non opportuniste.

Le prix d’achat moyen pondéré était de 2,162 $ par action, avec des transactions individuelles entre 2,06 $ et 2,25 $. Après la transaction, la participation directe de Liu a augmenté à 20 219 945 actions, soit une augmentation d’environ 0,10 % de sa part précédente.

Aucun titre dérivé n’a été déclaré et aucune vente n’a eu lieu. Bien que la valeur absolue de l’achat (~45 400 $) soit modeste par rapport à la détention globale de Liu, l’achat par un initié, en particulier un directeur avec une forte participation, peut être interprété comme un signe de confiance dans les perspectives de l’entreprise aux niveaux de prix actuels.

Prime Medicine, Inc. (PRME) – Insider-Transaktion Form 4

Direktor und 10%-Eigentümer David R. Liu meldete den Kauf von 21.000 Aktien von Prime Medicine am 23. Juni 2025. Die Transaktion erfolgte im Rahmen eines zuvor am 3. März 2025 eingeführten Rule 10b5-1 Plans, was darauf hinweist, dass es sich um einen vorab geplanten und nicht opportunistischen Kauf handelte.

Der gewichtete Durchschnittskaufpreis betrug 2,162 $ pro Aktie, mit Einzelkäufen zwischen 2,06 $ und 2,25 $. Nach der Transaktion erhöhte sich Liu’s Direktbeteiligung auf 20.219.945 Aktien, was einer Steigerung von etwa 0,10 % gegenüber seinem bisherigen Anteil entspricht.

Es wurden keine Derivate gemeldet und keine Verkäufe getätigt. Obwohl der absolute Kaufwert (~45.400 $) im Verhältnis zu Liu’s Gesamtbestand gering ist, kann der Kauf durch einen Insider, insbesondere einen Direktor mit hohem Anteil, als Vertrauensbeweis in die Aussichten des Unternehmens zu den aktuellen Kursniveaus gewertet werden.

Positive
  • Insider purchase by a 10 % owner/director signals confidence and strengthens ownership alignment.
  • Transaction executed under a Rule 10b5-1 plan demonstrates governance best practice and transparency.
Negative
  • Purchase size is immaterial (≈0.10 % increase in holding), limiting financial impact.

Insights

TL;DR: Minor insider buy; signal positive but immaterial to valuation.

The 21k-share purchase increases Liu’s stake to 20.22 m shares. At a $2.16 average, the outlay is negligible versus his existing position. Nevertheless, insider buying during a depressed price range typically supports sentiment and may ease market concerns regarding liquidity or near-term dilution. From a valuation perspective, the purchase does not alter earnings, cash flow, or strategic trajectory; therefore, impact on intrinsic value is minimal. Investors may view the filing as an incremental confidence indicator rather than a catalyst.

TL;DR: Scheduled 10b5-1 buy shows compliance and alignment.

The transaction was executed under a disclosed 10b5-1 plan, reinforcing adherence to governance best practices and reducing the likelihood of material non-public information abuse. Liu’s status as both director and 10 % owner already aligns his interests with shareholders; the additional shares marginally deepen that alignment. Governance risk remains unchanged, but transparency is a mild positive.

Prime Medicine, Inc. (PRME) – Transazione interna Form 4

Il direttore e proprietario del 10% David R. Liu ha comunicato l'acquisto di 21.000 azioni ordinarie di Prime Medicine il 23 giugno 2025. L'operazione è stata eseguita nell'ambito di un piano Rule 10b5-1 precedentemente adottato il 3 marzo 2025, indicando che si trattava di un acquisto programmato e non opportunistico.

Il prezzo medio ponderato di acquisto è stato di 2,162 $ per azione, con singole transazioni comprese tra 2,06 $ e 2,25 $. Dopo l'operazione, la partecipazione diretta di Liu è salita a 20.219.945 azioni, con un incremento di circa 0,10% rispetto alla sua quota precedente.

Non sono stati segnalati strumenti derivati né vendite. Sebbene il valore assoluto dell'acquisto (~45.400 $) sia modesto rispetto alla partecipazione complessiva di Liu, l'acquisto da parte di un insider, in particolare di un direttore con elevata quota, può essere interpretato come un segnale di fiducia nelle prospettive dell'azienda ai livelli di prezzo attuali.

Prime Medicine, Inc. (PRME) – Transacción interna Formulario 4

El director y propietario del 10% David R. Liu informó la compra de 21,000 acciones ordinarias de Prime Medicine el 23 de junio de 2025. La operación se realizó bajo un plan Rule 10b5-1 adoptado previamente el 3 de marzo de 2025, lo que indica que fue programada con anticipación y no oportunista.

El precio promedio ponderado de compra fue de $2.162 por acción, con transacciones individuales entre $2.06 y $2.25. Tras la operación, la propiedad directa de Liu aumentó a 20,219,945 acciones, sumando aproximadamente un 0.10% a su participación previa.

No se reportaron valores derivados ni ventas. Aunque el valor absoluto de la compra (~$45,400) es modesto en relación con la participación total de Liu, la compra por parte de un insider, especialmente un director con alta participación, puede interpretarse como una señal de confianza en las perspectivas de la compañía a los niveles de precio actuales.

Prime Medicine, Inc. (PRME) – Form 4 내부자 거래

이사이자 10% 지분 보유자인 David R. Liu2025년 6월 23일에 Prime Medicine 보통주 21,000주를 매수했다고 공시했습니다. 이 거래는 2025년 3월 3일에 채택된 Rule 10b5-1 계획에 따라 사전에 예약된 거래임을 나타냅니다.

주당 가중평균 매입가는 $2.162였으며, 개별 거래 가격은 $2.06에서 $2.25 사이였습니다. 거래 후 Liu의 직접 보유 주식은 20,219,945주로 약 0.10% 증가했습니다.

파생상품은 보고되지 않았고 매도도 없었습니다. 매수 금액(~$45,400)은 Liu의 전체 보유 지분에 비해 적은 편이지만, 특히 고지분 이사의 내부자 매수는 현재 가격 수준에서 회사의 전망에 대한 신뢰의 표시로 해석될 수 있습니다.

Prime Medicine, Inc. (PRME) – Transaction d’initié Formulaire 4

Le directeur et détenteur de 10 % David R. Liu a déclaré l’achat de 21 000 actions ordinaires de Prime Medicine le 23 juin 2025. La transaction a été réalisée dans le cadre d’un plan Rule 10b5-1 adopté le 3 mars 2025, indiquant qu’elle était programmée à l’avance et non opportuniste.

Le prix d’achat moyen pondéré était de 2,162 $ par action, avec des transactions individuelles entre 2,06 $ et 2,25 $. Après la transaction, la participation directe de Liu a augmenté à 20 219 945 actions, soit une augmentation d’environ 0,10 % de sa part précédente.

Aucun titre dérivé n’a été déclaré et aucune vente n’a eu lieu. Bien que la valeur absolue de l’achat (~45 400 $) soit modeste par rapport à la détention globale de Liu, l’achat par un initié, en particulier un directeur avec une forte participation, peut être interprété comme un signe de confiance dans les perspectives de l’entreprise aux niveaux de prix actuels.

Prime Medicine, Inc. (PRME) – Insider-Transaktion Form 4

Direktor und 10%-Eigentümer David R. Liu meldete den Kauf von 21.000 Aktien von Prime Medicine am 23. Juni 2025. Die Transaktion erfolgte im Rahmen eines zuvor am 3. März 2025 eingeführten Rule 10b5-1 Plans, was darauf hinweist, dass es sich um einen vorab geplanten und nicht opportunistischen Kauf handelte.

Der gewichtete Durchschnittskaufpreis betrug 2,162 $ pro Aktie, mit Einzelkäufen zwischen 2,06 $ und 2,25 $. Nach der Transaktion erhöhte sich Liu’s Direktbeteiligung auf 20.219.945 Aktien, was einer Steigerung von etwa 0,10 % gegenüber seinem bisherigen Anteil entspricht.

Es wurden keine Derivate gemeldet und keine Verkäufe getätigt. Obwohl der absolute Kaufwert (~45.400 $) im Verhältnis zu Liu’s Gesamtbestand gering ist, kann der Kauf durch einen Insider, insbesondere einen Direktor mit hohem Anteil, als Vertrauensbeweis in die Aussichten des Unternehmens zu den aktuellen Kursniveaus gewertet werden.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Liu David R.

(Last) (First) (Middle)
C/O PRIME MEDICINE, INC.
60 FIRST STREET

(Street)
CAMBRIDGE MA 02141

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Prime Medicine, Inc. [ PRME ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
06/23/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/23/2025 P(1) 21,000 A $2.162(2) 20,219,945 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 3, 2025.
2. The price reported in column 4 is a weighted-average price. These shares were purchased in multiple transactions at prices ranging from $2.06 to $2.25, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.
Remarks:
/s/ Ryan Brown, attorney-in-fact 06/23/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How many PRME shares did David R. Liu buy on 23-Jun-2025?

He purchased 21,000 shares of Prime Medicine common stock.

What was the average purchase price of the insider buy?

The weighted-average price reported was $2.162 per share, within a $2.06–$2.25 range.

How many PRME shares does Liu own after the transaction?

His direct beneficial ownership rose to 20,219,945 shares following the purchase.

Was the transaction part of a 10b5-1 trading plan?

Yes. The filing states the trade was made under a Rule 10b5-1 plan adopted on 3-Mar-2025.

Did the Form 4 report any derivative security activity?

No. No derivative securities were acquired or disposed of in the reported period.

Is the purchase considered material to Prime Medicine’s valuation?

Given the small size relative to Liu's total holding and PRME's share count, it is not material to valuation.
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