[Form 4] Q32 Bio Inc. Insider Trading Activity

Rhea-AI Filing Summary

Q32 Bio Inc. director Isaac Manke exercised stock options to acquire 53,521 shares of Common Stock on June 30, 2026 at an effective exercise price of $2.80 per share. Following the exercise, he directly holds 53,521 common shares and the corresponding option position reported in this filing has been fully exercised.

The exercised option, described as a Stock Option (Right to Buy), had granted rights over 53,521 shares of Common Stock and was fully vested and exercisable. After this transaction, the derivative position shown in the filing has a reported balance of 0 options, indicating a complete exercise of this award with no sale reported in this filing.

Insider Trade Summary

53,521 shares exercised/converted

Mixed 2 txns

Insider Manke Isaac

Role null

Type	Security	Shares	Price	Value
Exercise	Stock Option (Right to Buy)	53,521	$0.00	--
Exercise	Common Stock	53,521	$2.80	$150K

Holdings After Transaction: Stock Option (Right to Buy) — 0 shares (Direct, null); Common Stock — 53,521 shares (Direct, null)

Footnotes (1)

1. [object Object]

Key Figures

Shares acquired via exercise: 53,521 shares Exercise price: $2.80 per share Common shares held after: 53,521 shares +2 more

5 metrics

Shares acquired via exercise 53,521 shares Common Stock acquired on June 30, 2026

Exercise price $2.80 per share Conversion or exercise price of option

Common shares held after 53,521 shares Direct holdings following transaction

Options exercised 53,521 options Stock Option (Right to Buy) fully exercised

Remaining options 0 options Derivative position after exercise in this filing

Key Terms

Stock Option (Right to Buy), derivative security, Exercise or conversion of derivative security, fully vested and exercisable

4 terms

Stock Option (Right to Buy) financial

"The transaction involved a Stock Option (Right to Buy) derivative security."

derivative security financial

"The transaction involved a Stock Option (Right to Buy) derivative security."

A derivative security is a financial contract whose value comes from the price or performance of something else, such as a stock, bond, commodity, or market index. For investors it acts like an insurance policy or a wager: it can be used to protect against losses, lock in prices, or amplify gains and losses, so it can change a portfolio’s risk and potential return without owning the underlying asset directly.

Exercise or conversion of derivative security financial

"transaction_code_description: Exercise or conversion of derivative security"

fully vested and exercisable financial

"The shares underlying this option are fully vested and exercisable."

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Form 4 Insider Transactions: What Each Field Means →

Available on EDGAR 07/02/2026 - 04:31 PM Accepted by SEC EDGAR 07/02/2026 - 04:30 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Manke Isaac

(Last) (First) (Middle)

Q32 BIO INC.

830 WINTER STREET

(Street)

WALTHAM MASSACHUSETTS 02451

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Q32 Bio Inc. [ QTTB ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
06/30/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	06/30/2026		M		53,521	A	$2.8	53,521	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$2.8	06/30/2026		M			53,521	(1)	10/22/2035	Common Stock	53,521	$0.00	0	D

Explanation of Responses:

1. The shares underlying this option are fully vested and exercisable.

	/s/ Eric Bell, Attorney-in-Fact	07/02/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)