Tax sell-to-cover by Avidity (RNA) chief medical officer after RSU vesting

Rhea-AI Filing Summary

Avidity Biosciences, Inc. Chief Medical Officer Steven George Hughes reported automatic sales of common stock to cover taxes on vested RSUs. On January 21, 2026, he sold 2,017 shares of common stock at $72.45 per share, then a further 2,878 shares at the same price. After these transactions, he beneficially owned 31,599 shares of Avidity common stock directly.

According to the footnote, these transactions represent shares sold to satisfy tax withholding obligations arising from RSUs that vested on January 20, 2026. The sales were mandated under the company’s equity incentive plans as a “sell-to-cover” arrangement and are described as non-discretionary trades. The reporting person executed an instruction letter for automatic sale of these sell-to-cover shares intended to meet the affirmative defense conditions of Rule 10b5-1.

Insider Trade Summary

Net Seller: 4,895 shares ($354,643)

Net Sell 2 txns

Insider Hughes Steven George

Role Chief Medical Officer

Sold 4,895 shs ($355K)

Type	Security	Shares	Price	Value
Sale	Common Stock	2,017	$72.45	$146K
Sale	Common Stock	2,878	$72.45	$209K

Holdings After Transaction: Common Stock — 34,477 shares (Direct)

Footnotes (1)

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Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Hughes Steven George

(Last) (First) (Middle)

C/O AVIDITY BIOSCIENCES, INC.

3020 CALLAN RD.

(Street)

SAN DIEGO CA 92121

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Avidity Biosciences, Inc. [ RNA ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Medical Officer

3. Date of Earliest Transaction (Month/Day/Year)
01/21/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	01/21/2026		S		2,017(1)	D	$72.45	34,477	D
Common Stock	01/21/2026		S		2,878(1)	D	$72.45	31,599	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs on January 20, 2026 and the sale of the resulting shares of common stock on January 21, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell-to-cover" transaction and does not represent a discretionary trade by the Reporting Person. The Reporting Person has executed an instruction letter for the automatic sale of such "sell-to-cover" shares, intended to satisfy the affirmative defense conditions of Rule 10b5-1.

Remarks:

	/s/ John B. Moriarty, Jr., J.D., Attorney-in-Fact	01/23/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider activity did RNA Avidity Biosciences report in this Form 4?

The filing shows that Chief Medical Officer Steven George Hughes sold Avidity Biosciences common stock in two transactions on January 21, 2026, totaling 2,017 shares and 2,878 shares at $72.45 per share, in connection with RSU vesting.

How many Avidity Biosciences (RNA) shares does the CMO hold after these transactions?

Following the reported sell-to-cover transactions, Steven George Hughes beneficially owned 31,599 shares of Avidity Biosciences common stock directly.

Were the Avidity Biosciences insider sales discretionary trades?

No. The footnote explains that the sales were mandated by the company’s equity incentive plans as a “sell-to-cover” transaction to fund tax withholding on RSUs that vested on January 20, 2026, and do not represent discretionary trades by the reporting person.

Why were Avidity Biosciences (RNA) shares sold on January 21, 2026?

The shares were sold to cover tax withholding obligations arising from the vesting of restricted stock units (RSUs) on January 20, 2026, as required under Avidity’s equity incentive plans.

What is the relevance of Rule 10b5-1 in this Avidity Biosciences Form 4?

The filing notes that the reporting person executed an instruction letter for automatic sale of the sell-to-cover shares, intended to satisfy the affirmative defense conditions of Rule 10b5-1.

What was the sale price of the Avidity Biosciences shares sold by the CMO?

Both reported transactions were sales of Avidity Biosciences common stock at a price of $72.45 per share on January 21, 2026.