Rhythm Pharmaceu SEC Filings

Rhythm Pharmaceuticals (RYTM)11/20/2025, the officer exercised 3,350 stock options at an exercise price of $27.35 per share and acquired the same number of common shares. On the same date, 3,350 common shares were sold at a price of $105 per share under a pre-arranged Rule 10b5-1 trading plan adopted on August 7, 2025.

After these transactions, the officer beneficially owned 20,814 shares of common stock directly and held 11,725 stock options that remain beneficially owned. The options exercised on November 20, 2025 were part of a grant made on February 1, 2023 that vests in 16 substantially equal quarterly installments, tied to continued service with the company.

Rhythm Pharmaceuticals (RYTM) insider activity: Chief Human Resources Officer Pamela J. Cramer reported option exercises and open‑market sales. On 11/07/2025, she exercised 8,805 options at $19.02 and 10,546 options at $6.80, then sold 19,351 shares at a weighted average price of $98.8231. On 11/10/2025, she exercised 3,515 options at $6.80 and sold 3,515 shares at $100.00.

Following these transactions, directly held common shares were 20,814. The sales were effected under a Rule 10b5‑1 trading plan adopted on August 7, 2025.

Derivative updates: post‑exercise, option holdings were 5,257 at a $19.02 strike (expires 07/25/2031) and 7,035 and 3,520 at a $6.80 strike (expire 02/08/2032). The filing notes one option grant is fully vested and another vests in 16 equal quarterly installments from February 9, 2022.

Rhythm Pharmaceuticals reported a regulatory timing update. The U.S. Food and Drug Administration extended the Prescription Drug User Fee Act (PDUFA) goal date for the supplemental New Drug Application for IMCIVREE (setmelanotide) to treat acquired hypothalamic obesity by three months, moving it from December 20, 2025 to March 20, 2026.

The company also furnished a press release and an investor presentation as exhibits to provide additional context. Information furnished under Regulation FD is not deemed filed for liability purposes.

Rhythm Pharmaceuticals (RYTM) filed its Q3 2025 10‑Q reporting higher sales and a narrower year‑to‑date loss. Q3 product revenue was $51.3 million, up from $33.3 million a year ago, reflecting continued uptake of IMCIVREE. The quarter’s net loss attributable to common stockholders was $54.3 million, or $0.82 per share.

For the nine months, revenue reached $132.5 million while the net loss narrowed to $149.0 million, helped by lower research and development expense ($125.3 million vs. $196.8 million in 2024) and higher selling, general and administrative expense supporting commercialization. Cash, cash equivalents and short‑term investments totaled $416.1 million as of September 30, 2025, with operating cash outflow of $90.3 million year‑to‑date. The company completed a public offering during the period, adding $188.7 million in net proceeds and also raised $34.0 million via an at‑the‑market program. Shares outstanding were 66,736,056 as of October 31, 2025.

Rhythm Pharmaceuticals (RYTM) Chief Technical Officer Joseph Shulman filed a Form 4 detailing an option exercise and same‑day sale on 10/30/2025. He exercised 9,748 stock options at $30.66 and then sold 9,748 common shares at a weighted average price of $115.2439.

The sales were executed in multiple trades between $115.00 and $115.73 and were made pursuant to a Rule 10b5‑1 plan adopted on August 8, 2024. Following these transactions, Shulman beneficially owns 8,509 shares directly. The reported stock option was fully vested prior to exercise and shows zero derivative securities remaining after the transaction.

Rhythm Pharmaceuticals (RYTM) reported an insider transaction by Chief Technical Officer Joseph Shulman. On 10/28/2025, he exercised employee stock options for 2,094 shares at an exercise price of $27.35 and 721 shares at $30.66, then sold 2,815 shares of common stock at a weighted average price of $115.0089. The sale was made pursuant to a Rule 10b5‑1 trading plan adopted on August 8, 2024.

Following these transactions, Shulman beneficially owned 8,509 shares directly. The filing notes the sales occurred in multiple trades between $115.00 and $115.08. The option grant dated February 1, 2023 vests in 16 substantially equal quarterly installments, and another option referenced is fully vested. Derivative holdings reported after the transactions include option positions totaling 12,563 and 9,748 underlying shares, respectively.

Rhythm Pharmaceuticals (RYTM) reported insider activity by its Chief Technical Officer. On 10/16/2025, the officer exercised stock options for 2,093 shares at $27.35 and 12,344 shares at $30.66, then sold 2,693 shares at a weighted average $110.9482, 8,332 shares at $112.0554, and 3,412 shares at $112.81. The trades were made under a Rule 10b5-1 plan adopted on August 8, 2024. Following the transactions, the officer reported 8,509 shares beneficially owned directly. Option holdings reported after the exercises were 14,657 (at $27.35) and 10,469 (at $30.66).

Joseph Shulman, Chief Technical Officer of Rhythm Pharmaceuticals, reported changes in his beneficial ownership on Form 4. On 09/02/2025 he acquired 2,094 shares by exercising options with an exercise price of $27.35 and acquired 14,687 shares by exercising options with an exercise price of $30.66, bringing his post-transaction common stock holdings to 25,290 shares (direct). The filing also reports a sale of 16,781 shares on the same date under a Rule 10b5-1 instruction adopted August 8, 2024, at a weighted-average sale price of $105.298, leaving 8,509 shares owned after the sale. Option grants referenced were dated February 1, 2023 and February 11, 2021 with multi-period vesting schedules.