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Rezolute, Inc. (RZLT) beneficial ownership amendment reports that Opaleye Management Inc. and James Silverman each beneficially owned 3,952,045 common shares, or 4.09% of the class; Opaleye, L.P. reported 3,925,000 shares, or 4.06%. The reported holdings included 3,925,000 shares held directly by the Fund and 27,045 held directly by a separately managed account.
The Adviser and Silverman each reported shared voting and dispositive power over 3,952,045 shares, while the Fund reported shared power over 3,925,000; each reported zero sole voting and dispositive power. The percentages were based on 96,722,333 common shares outstanding as of September 21, 2026. The statement says it is not an admission that any reporting person is a beneficial owner for purposes of Section 13.
Key Figures
Shares beneficially owned:3,952,045 sharesShares beneficially owned:3,925,000 sharesShares held directly by the Fund:3,925,000 shares+2 more
5 metrics
Shares beneficially owned3,952,045 sharesReported by Opaleye Management Inc. and James Silverman; 4.09% of the class for each.
Shares beneficially owned3,925,000 sharesReported by Opaleye, L.P.; 4.06% of the class.
Shares held directly by the Fund3,925,000 sharesOpaleye, L.P. directly held these shares.
Shares held directly by the separately managed account27,045 sharesThe account's shares were included in the holdings reported by Opaleye Management Inc. and James Silverman.
Common shares outstanding96,722,333 sharesAs of September 21, 2026; used as the basis for the reported ownership percentages.
Key Terms
beneficial ownership, shared voting power, shared dispositive power
3 terms
beneficial ownershipregulatory
"Aggregate amount beneficially owned by each reporting person"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
shared voting powerregulatory
"Shared voting power over the reported shares"
Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.
shared dispositive powerregulatory
"Shared dispositive power over the reported shares"
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
How many RZLT shares did Opaleye report beneficially owning?
Opaleye Management Inc. and James Silverman each reported beneficial ownership of 3,952,045 shares, while Opaleye, L.P. reported 3,925,000 shares. The Fund directly held 3,925,000 shares, and a separately managed account directly held 27,045 shares.
What percentage of RZLT did Opaleye report owning?
Opaleye Management Inc. and James Silverman each reported 4.09%, and Opaleye, L.P. reported 4.06%. The percentages were based on 96,722,333 common shares outstanding as of September 21, 2026.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 3)
Rezolute, Inc.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
76200L309
(CUSIP Number)
09/30/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
76200L309
1
Names of Reporting Persons
Opaleye Management Inc.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
MASSACHUSETTS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,952,045.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,952,045.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,952,045.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.09 %
12
Type of Reporting Person (See Instructions)
IA, CO
SCHEDULE 13G
CUSIP Number(s):
76200L309
1
Names of Reporting Persons
Opaleye, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,925,000.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,925,000.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,925,000.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.06 %
12
Type of Reporting Person (See Instructions)
PN
SCHEDULE 13G
CUSIP Number(s):
76200L309
1
Names of Reporting Persons
James Silverman
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,952,045.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,952,045.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,952,045.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.09 %
12
Type of Reporting Person (See Instructions)
IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Rezolute, Inc.
(b)
Address of issuer's principal executive offices:
275 SHORELINE DRIVE, SUITE 500 REDWOOD CITY CA 94065
Item 2.
(a)
Name of person filing:
Opaleye Management Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund and by a separately managed account (the "Account"). The Fund directly holds 3,925,000 shares and the Account directly holds 27,045 shares. The Adviser serves as investment adviser to the Fund and the Account. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein.
(b)
Address or principal business office or, if none, residence:
One Boston Place, 26th Floor, Boston, MA 02108
(c)
Citizenship:
Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Delaware James Silverman - USA
(d)
Title of class of securities:
Common Stock
(e)
CUSIP No.:
76200L309
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
3,952,045.00
(b)
Percent of class:
4.09 %
Based on 96,722,333 Common Shares outstanding as of 09/21/2026 as reported by Rezolute, Inc. on 09/24/2026, in its 10-K Annual Report.
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
0.00
(ii) Shared power to vote or to direct the vote:
3,952,045.00
(iii) Sole power to dispose or to direct the disposition of:
0.00
(iv) Shared power to dispose or to direct the disposition of:
3,952,045.00
Item 5.
Ownership of 5 Percent or Less of a Class.
Ownership of 5 percent or less of a class
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
Not Applicable
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Opaleye Management Inc.
Signature:
/s/ James Silverman
Name/Title:
President
Date:
11/13/2026
Opaleye, L.P.
Signature:
Opaleye GP LLC, its general partner /s/ James Silverman
Name/Title:
Managing Member
Date:
11/13/2026
James Silverman
Signature:
/s/ James Silverman
Name/Title:
Individually
Date:
11/13/2026
Exhibit Information
Exhibit 99.1 Joint Filing Agreement by and among the reporting persons
