STOCK TITAN

Septerna (SEPN) SVP sells 15,000 shares under 10b5-1 plan

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Septerna, Inc. SVP of Drug Discovery Daniel D. Long reported option exercises and share sales in SEPN stock. On June 22, 2026, he exercised options for 4,471 shares at $11.70 per share and 10,529 shares at $2.76 per share, converting them into common stock.

On the same date, he sold 7,000 shares at a weighted average price of $35.9687 and 8,000 shares at $35.1001 in open-market transactions under a pre-arranged Rule 10b5-1 sales plan. After these transactions, he directly holds 96,412 shares of common stock.

Positive

  • None.

Negative

  • None.
Insider Long Daniel D.
Role SVP, Drug Discovery
Sold 15,000 shs ($533K)
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) 10,529 $0.00 --
Exercise Stock Option (Right to Buy) 4,471 $0.00 --
Exercise Common Stock 10,529 $2.76 $29K
Exercise Common Stock 4,471 $11.70 $52K
Sale Common Stock 8,000 $35.1001 $281K
Sale Common Stock 7,000 $35.9687 $252K
Holdings After Transaction: Stock Option (Right to Buy) — 10,376 shares (Direct, null); Common Stock — 106,941 shares (Direct, null)
Footnotes (1)
  1. Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on April 30, 2026 in a transaction that was exempt under Rule 16b-3(c). This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on March 20, 2026. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.70 to $35.64. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.71 to $36.34. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.
Shares sold 15,000 shares Common stock sold in open-market transactions on June 22, 2026
First sale price $35.9687/share 7,000 common shares sold at weighted average price
Second sale price $35.1001/share 8,000 common shares sold at weighted average price
Options exercised at $11.70 4,471 shares Common stock acquired via option exercise
Options exercised at $2.76 10,529 shares Common stock acquired via option exercise
Shares held after transactions 96,412 shares Direct ownership of Septerna common stock after June 22, 2026
ESPP shares acquired 3,501 shares Acquired April 30, 2026 under 2024 Employee Stock Purchase Plan
10b5-1 plan adoption date March 20, 2026 Pre-arranged sales plan governing reported stock sales
Rule 10b5-1 regulatory
"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on March 20, 2026."
Rule 10b5-1 is a regulation that allows company insiders to buy or sell their shares at predetermined times, even if they have access to non-public information. It acts like setting a schedule in advance for transactions, helping prevent accusations of unfair trading. This rule provides a way for insiders to plan trades transparently, giving investors confidence that these transactions are not based on hidden information.
weighted average price financial
"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.70 to $35.64."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
Employee Stock Purchase Plan financial
"Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on April 30, 2026 in a transaction that was exempt under Rule 16b-3(c)."
An employee stock purchase plan is a company program that lets workers buy shares through small payroll deductions, often at a discount to the market price and after a set offering period. Think of it like a workplace savings plan that turns into ownership: it encourages employees to share in the company’s success and can create predictable buying or selling of stock that investors watch because it affects supply, demand and employee incentives.
Rule 16b-3(c) regulatory
"Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on April 30, 2026 in a transaction that was exempt under Rule 16b-3(c)."
An SEC rule that lets corporate insiders avoid automatic "short‑swing" profit recovery when they buy or sell their company’s stock under a pre‑approved, written plan that meets specific conditions. For investors, it matters because it clarifies when insider trades are treated as routine, reducing legal uncertainty and helping distinguish trades made for ordinary compensation or pre‑planned reasons from those that might signal opportunistic or timely insider advantage.
Stock Option (Right to Buy) financial
"Stock Option (Right to Buy) with 4,471 shares and a $11.7000 conversion or exercise price."
derivative exercise/conversion financial
"transaction_action": "derivative exercise/conversion" for option transactions converting into common stock."
See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google
Add on Google
Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Long Daniel D.

(Last)(First)(Middle)
C/O SEPTERNA, INC.
250 EAST GRAND AVENUE

(Street)
SOUTH SAN FRANCISCO CALIFORNIA 94080

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
SVP, Drug Discovery
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
06/22/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock06/22/2026M10,529A$2.76106,941(1)D
Common Stock06/22/2026M4,471A$11.7111,412D
Common Stock06/22/2026S(2)8,000D$35.1001(3)103,412D
Common Stock06/22/2026S(2)7,000D$35.9687(4)96,412D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$2.7606/22/2026M10,529 (5)11/11/2033Common Stock10,529$010,376D
Stock Option (Right to Buy)$11.706/22/2026M4,471 (6)08/06/2035Common Stock4,471$025,529D
Explanation of Responses:
1. Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on April 30, 2026 in a transaction that was exempt under Rule 16b-3(c).
2. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on March 20, 2026.
3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.70 to $35.64. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.71 to $36.34. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
5. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date.
6. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.
/s/ Mark A. Wilson, Attorney-in-Fact06/24/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Septerna (SEPN) SVP Daniel Long report?

Daniel D. Long reported both option exercises and share sales. He exercised options for 15,000 Septerna common shares, then sold 15,000 shares in open-market trades, while continuing to hold 96,412 shares directly after the transactions.

How many Septerna (SEPN) shares did the SVP sell and at what prices?

He sold 7,000 Septerna common shares at a weighted average price of $35.9687 and 8,000 shares at $35.1001. The sales occurred in multiple trades within disclosed price ranges on June 22, 2026.

What stock options did the Septerna (SEPN) SVP exercise in this filing?

He exercised options covering 4,471 Septerna shares at a $11.70 exercise price and 10,529 shares at a $2.76 exercise price. These option exercises converted derivative positions into common stock before the related share sales.

Were the Septerna (SEPN) insider sales made under a Rule 10b5-1 plan?

Yes. A footnote states the sales were effected pursuant to a Rule 10b5-1 sales plan adopted by Daniel D. Long on March 20, 2026, indicating the trades were pre-arranged rather than timed discretionarily.

How many Septerna (SEPN) shares does the SVP hold after these transactions?

Following the reported option exercises and open-market sales, Daniel D. Long directly holds 96,412 shares of Septerna common stock. This remaining stake reflects his continuing equity exposure after the June 22, 2026 activity.

What other recent share acquisitions are noted for Septerna (SEPN) SVP Daniel Long?

A footnote notes that his holdings include 3,501 shares acquired on April 30, 2026 under the Septerna, Inc. 2024 Employee Stock Purchase Plan in a transaction exempt under Rule 16b-3(c).