STOCK TITAN

Septerna (SEPN) SVP exercises options and sells 3,334 shares under plan

(Neutral)
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Septerna, Inc. reported that Daniel D. Long, SVP, Drug Discovery, exercised employee stock options covering 3,334 shares of common stock at an exercise price of $2.7600 per share on August 3, 2026, converting derivative awards into common shares.

On the same date he sold 3,334 shares of common stock in two blocks: 1,000 shares at a weighted average price of $33.9756 per share within a $33.39–$34.32 range, and 2,334 shares at a weighted average price of $34.6805 per share within a $34.43–$35.04 range. These sales were effected pursuant to a Rule 10b5-1 sales plan adopted on March 20, 2026. Related options vest in 48 equal monthly installments starting August 1, 2023 and March 1, 2024, subject to continued service.

Positive

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Insider Long Daniel D.
Role SVP, Drug Discovery
Sold 3,334 shs ($115K)
Approx. gross sale proceeds $115K
Approx. exercise cost $9K
Approx. pre-tax spread $106K
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) F4 1,816 $0.00 $0.00
Exercise Stock Option (Right to Buy) F5 1,518 $0.00 $0.00
Exercise Common Stock 1,816 $2.76 $5K
Exercise Common Stock 1,518 $2.76 $4K
Sale Common Stock F1, F2 1,000 $33.9756 $34K
Sale Common Stock F1, F3 2,334 $34.6805 $81K
Holdings After Transaction: Stock Option (Right to Buy) — 17,645 shares (Direct); Common Stock — 96,412 shares (Direct)
Footnotes (5)
  1. F1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on March 20, 2026.
  2. F2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.39 to $34.32. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
  3. F3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.43 to $35.04. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
  4. F4. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date.
  5. F5. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.
Options exercised 3,334 shares Total underlying common stock from option exercises on August 3, 2026
Exercise price $2.7600 per share Exercise price for stock options converted into common stock
Shares sold 3,334 shares Total Septerna common shares sold on August 3, 2026
Weighted avg sale price (1,000 shares) $33.9756 per share Weighted average price for 1,000 shares sold within a $33.39–$34.32 range
Weighted avg sale price (2,334 shares) $34.6805 per share Weighted average price for 2,334 shares sold within a $34.43–$35.04 range
10b5-1 plan adoption date March 20, 2026 Adoption date of Rule 10b5-1 sales plan governing the reported sales
Rule 10b5-1 sales plan regulatory
"This transaction was effected pursuant to a Rule 10b5-1 sales plan"
weighted average price financial
"The price reported in Column 4 is a weighted average price"
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
Stock Option (Right to Buy) financial
"security_title: Stock Option (Right to Buy) reported for options"
vest and become exercisable financial
"1/48th of the shares subject to such option shall vest and become exercisable"

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What insider stock activity did Septerna (SEPN) report for Daniel D. Long?

Daniel D. Long exercised options for 3,334 shares of Septerna common stock at $2.7600 per share and sold 3,334 shares on August 3, 2026. The sales occurred in two weighted-average priced blocks around $34 per share.

How many Septerna (SEPN) shares did Daniel D. Long sell and at what prices?

He sold a total of 3,334 shares of Septerna common stock. One block of 1,000 shares was sold at a weighted average of $33.9756, and 2,334 shares at a weighted average of $34.6805, within disclosed intraday price ranges.

Were Daniel D. Long’s Septerna (SEPN) share sales under a Rule 10b5-1 plan?

Yes. The reported sales were effected under a Rule 10b5-1 sales plan adopted by Daniel D. Long on March 20, 2026. Such plans pre-schedule trades, which can reduce the informational value of transaction timing for outside investors.

What options did Daniel D. Long exercise in Septerna (SEPN) stock?

He exercised stock options covering 3,334 shares of Septerna common stock at an exercise price of $2.7600 per share. The options had expirations in 2033 and 2034 and were part of equity awards vesting monthly over 48 months.

How do Daniel D. Long’s Septerna (SEPN) options vest?

The option series referenced vest so that 1/48th of the shares become exercisable each month. One grant vests monthly from August 1, 2023, and another from March 1, 2024, in each case contingent on his continuous service with Septerna.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Long Daniel D.

(Last)(First)(Middle)
C/O SEPTERNA, INC.
250 EAST GRAND AVENUE

(Street)
SOUTH SAN FRANCISCO CALIFORNIA 94080

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
SVP, Drug Discovery
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
08/03/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock08/03/2026M1,816A$2.7698,228D
Common Stock08/03/2026M1,518A$2.7699,746D
Common Stock08/03/2026S(1)1,000D$33.9756(2)98,746D
Common Stock08/03/2026S(1)2,334D$34.6805(3)96,412D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$2.7608/03/2026M1,816 (4)11/11/2033Common Stock1,816$05,227D
Stock Option (Right to Buy)$2.7608/03/2026M1,518 (5)03/19/2034Common Stock1,518$012,418D
Explanation of Responses:
1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on March 20, 2026.
2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.39 to $34.32. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.43 to $35.04. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
4. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date.
5. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.
/s/ Mark A. Wilson, Attorney-in-Fact08/05/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)