[Form 4] Septerna, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Director Abraham Bassan of Septerna received a stock option grant for 16,623 shares of common stock on June 17, 2025. The options were granted with an exercise price of $10.24 per share and will expire on June 16, 2035.

Key terms of the option grant:

• Full vesting occurs at the earlier of June 17, 2026 or the next annual stockholder meeting
• Vesting is contingent on continued service with the company
• The options represent a new derivative security position, with direct ownership

This Form 4 filing, signed by Jeffrey Finer as attorney-in-fact on June 20, 2025, reports the transaction under Section 16(a) of the Securities Exchange Act of 1934. The grant appears to be part of the company's director compensation program.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Bassan Abraham

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
06/17/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$10.24	06/17/2025		A		16,623		(1)	06/16/2035	Common Stock	16,623	$0	16,623	D

Explanation of Responses:

1. The shares underlying the stock option will vest in full upon the earlier of (i) June 17, 2026 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

	/s/ Jeffrey Finer, Attorney-in-Fact	06/20/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What stock options did SEPN director Abraham Bassan receive on June 17, 2025?

Abraham Bassan received 16,623 stock options with an exercise price of $10.24 per share. These options were granted on June 17, 2025, and expire on June 16, 2035.

What are the vesting terms for SEPN director Bassan's June 2025 stock options?

The stock options will vest in full upon the earlier of either (i) June 17, 2026, or (ii) Septerna's next annual meeting of stockholders, subject to Bassan's continued service to the company through the vesting date.

How many shares of SEPN can Abraham Bassan purchase with his new stock options?

Abraham Bassan can purchase 16,623 shares of SEPN common stock through these stock options at an exercise price of $10.24 per share.

When did SEPN director Abraham Bassan report his stock option grant to the SEC?

The Form 4 reporting the stock option grant was signed by Jeffrey Finer (as Attorney-in-Fact) on June 20, 2025, and filed with the SEC on June 28, 2025.

What is Abraham Bassan's role at SEPN according to the Form 4?

According to the Form 4 filing, Abraham Bassan serves as a Director of Septerna, Inc. (SEPN). He is not indicated as an officer or 10% owner of the company.