Septerna (SEPN) director receives stock option grant for 11,260 shares

Rhea-AI Filing Summary

Septerna, Inc. director Keith Michael Gottesdiener received a grant of stock options covering 11,260 shares of common stock. The options carry an exercise price of $37.34 per share and expire on June 25, 2036.

These options vest in full on the earlier of June 26, 2027 or the date of Septerna’s next annual meeting of stockholders, as long as he continues serving the company through that date. After this grant, he holds 11,260 stock options directly.

Insights

Equity Compensation Analyst

Routine director option grant with time-based vesting.

The filing shows Septerna granted director Keith Michael Gottesdiener stock options for 11,260 shares at an exercise price of $37.34, expiring in 2036. This is categorized as a grant or award acquisition, not an open-market purchase or sale.

The options vest fully on the earlier of June 26, 2027 or the company’s next annual stockholder meeting, conditional on continued service. This is a standard time-based vesting structure that aligns director incentives with long-term shareholder value, and represents a routine governance and compensation event rather than a trading signal.

Insider Trade Summary

1 transaction reported

Mixed 1 txn

Insider Gottesdiener Keith Michael

Role Director

Type	Security	Shares	Price	Value
Grant/Award	Stock Option (Right to Buy)	11,260	$0.00	$0.00

Holdings After Transaction: Stock Option (Right to Buy) — 11,260 shares (Direct)

Footnotes (1)

1. F1. The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Key Figures

Option grant size: 11,260 options Exercise price: $37.34 per share Expiration date: June 25, 2036 +2 more

5 metrics

Option grant size 11,260 options Underlying 11,260 shares of common stock

Exercise price $37.34 per share Stock option exercise price

Expiration date June 25, 2036 Stock option expiry

Post-grant derivative holdings 11,260 options Total derivative securities following transaction

Vesting date trigger June 26, 2027 Earlier of this date or next annual meeting

Key Terms

Stock Option (Right to Buy), exercise price, vesting, annual meeting of stockholders, +1 more

5 terms

Stock Option (Right to Buy) financial

"security_title: "Stock Option (Right to Buy)""

exercise price financial

"conversion_or_exercise_price: "37.3400""

The exercise price is the fixed amount at which you can buy or sell an asset, like a stock, when using an options contract. It matters because it helps determine whether exercising the option will be profitable or not, depending on the current market price. Think of it as the set price you agree on today to buy or sell later.

vesting financial

"The shares underlying the stock option vest in full upon the earlier of"

Vesting is the process by which you earn full ownership of something, like company stock or a retirement benefit, over time. It’s like earning the right to keep a gift piece by piece the longer you stay with a company, making sure employees stay committed before they receive all the benefits.

annual meeting of stockholders financial

"or (ii) the date of the Issuer's next annual meeting of stockholders"

Grant, award, or other acquisition financial

"transaction_code_description: "Grant, award, or other acquisition""

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Form 4 Insider Transactions: What Each Field Means →

Available on EDGAR 06/30/2026 - 07:00 PM Accepted by SEC EDGAR 06/30/2026 - 07:00 PM Learn about SEC filing dates

FAQ

What did Septerna (SEPN) director Keith Michael Gottesdiener report in this Form 4?

He reported receiving a grant of stock options for 11,260 Septerna common shares. The options were awarded at an exercise price of $37.34 per share and are held directly, reflecting a compensation-related acquisition rather than an open-market trade.

What are the key terms of the Septerna (SEPN) stock options granted to the director?

The grant covers 11,260 underlying common shares with an exercise price of $37.34 per share. The options expire on June 25, 2036, giving the director a long-dated opportunity to buy Septerna stock at that fixed price if conditions are met.

When do Keith Michael Gottesdiener’s Septerna (SEPN) stock options vest?

The options vest in full on the earlier of June 26, 2027 or Septerna’s next annual meeting of stockholders. Vesting is conditional on his continued service to the company through that vesting date, making this a standard time-based vesting grant.

Is the Septerna (SEPN) Form 4 transaction a stock purchase or sale?

It is neither a market purchase nor a sale; it is a grant of options. The filing classifies the transaction as a grant, award, or other acquisition, with no cash market trade reported and no shares sold into the open market in this event.

How many Septerna (SEPN) derivative securities does the director hold after this grant?

Following the transaction, the director holds 11,260 stock options directly. Each option relates to one share of Septerna common stock, so the position represents rights over 11,260 underlying shares, subject to vesting and future exercise decisions.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Gottesdiener Keith Michael

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
06/26/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$37.34	06/26/2026		A		11,260		(1)	06/25/2036	Common Stock	11,260	$0	11,260	D

Explanation of Responses:

1. The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	06/30/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)