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Opaleye buys 40K Sol-Gel Technologies shares

Sol-Gel Technologies Ltd. (SLGL) reports that large shareholder Opaleye Management Inc. filed a Form 4 showing open-market purchases of 40,330 ordinary shares on August 28 and 31, 2026.

(Very High)
(Positive)
Form Type
4

Rhea-AI Filing Summary

Sol-Gel Technologies Ltd. (SLGL) reports that large shareholder Opaleye Management Inc. filed a Form 4 showing open-market purchases of 40,330 ordinary shares on August 28 and 31, 2026. The shares were acquired indirectly through Opaleye, L.P. and a separately managed account, with 15,000 shares reported as held in the managed account. Certain trades used weighted average prices within disclosed ranges, and Opaleye Management Inc. disclaims beneficial ownership except to the extent of its pecuniary interest.

Positive

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Negative

  • None.

Insights

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Insider Opaleye Management Inc.
Role 10% Owner
Bought 40,330 shs ($2.79M)
Type Security Shares Price Value
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 5,000 $68.235 $341K
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 217 $69.10 $15K
Purchase Ordinary Shares, par value NIS 1.00 per share F3, F1, F5 10,000 $71.3969 $714K
Purchase Ordinary Shares, par value NIS 1.00 per share F4, F1, F5 20,113 $68.4203 $1.38M
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F5 5,000 $68.81 $344K
holding Ordinary Shares, par value NIS 1.00 per share F2, F5 -- -- --
Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share — 525,217 shares (Indirect, By Opaleye, L.P.); Ordinary Shares, par value NIS 1.00 per share — 15,000 shares (Indirect, By Managed Account)
Footnotes (5)
  1. F1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
  2. F2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
  3. F3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $69.145-$74.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
  4. F4. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $66.15-$69.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
  5. F5. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Total shares purchased 40,330 shares Net open-market purchases reported across all transactions in this Form 4
Purchase on 2026-08-31 5,000 shares at $68.2350 per share Ordinary Shares acquired indirectly via Opaleye, L.P.
Additional purchase on 2026-08-31 217 shares at $69.1000 per share Ordinary Shares acquired indirectly via Opaleye, L.P.
Weighted average purchase price $71.3969 per share 10,000-share purchase on 2026-08-28; underlying range $69.145–$74.77
Weighted average purchase price $68.4203 per share 20,113-share purchase on 2026-08-28; underlying range $66.15–$69.77
Managed account holdings 15,000 shares Ordinary Shares held indirectly by a separately managed account as of 2026-08-28
weighted average price financial
"The price reported in column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
beneficially own regulatory
"may be deemed to beneficially own the securities owned directly"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
pecuniary interest financial
"disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest"
separately managed account financial
"Securities owned by a separately managed account (the "Managed Account")."
A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.
ten percent owner regulatory
"is_ten_percent_owner": 1"

FAQ

What insider activity did Opaleye Management report for SLGL on this Form 4?

Opaleye Management Inc. reported purchases of 40,330 Sol-Gel (SLGL) ordinary shares in open-market transactions on August 28 and 31, 2026, all held indirectly through Opaleye, L.P. and a separately managed account.

What prices were paid in the SLGL insider purchases?

Reported Sol-Gel (SLGL) purchase prices include $68.2350, $69.1000, and $68.8100 per share, plus weighted average prices of $71.3969 and $68.4203, with underlying ranges of $69.145–$74.77 and $66.15–$69.77, respectively.

How many SLGL shares are held in the managed account after these transactions?

The Form 4 reports that a separately managed account associated with Opaleye Management Inc. holds 15,000 Sol-Gel (SLGL) ordinary shares indirectly after the reported transactions.

Does Opaleye Management claim full beneficial ownership of the SLGL shares?

No. Opaleye Management Inc. states it disclaims beneficial ownership of the reported Sol-Gel (SLGL) shares except to the extent of its pecuniary interest, despite being investment manager or portfolio manager for the entities holding the shares.

Were any SLGL shares sold by Opaleye Management in this Form 4?

No sales are reported. The Form 4 shows net purchases of 40,330 Sol-Gel (SLGL) shares and no dispositions, according to the transaction summary.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last)(First)(Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02108

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
08/28/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares, par value NIS 1.00 per share08/28/2026P10,000A$71.3969(3)494,887IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share08/28/2026P20,113A$68.4203(4)515,000IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share08/28/2026P5,000A$68.81520,000IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share08/31/2026P5,000A$68.235525,000IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share08/31/2026P217A$69.1525,217IBy Opaleye, L.P.(1)(5)
Ordinary Shares, par value NIS 1.00 per share15,000IBy Managed Account(2)(5)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
3. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $69.145-$74.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
4. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $66.15-$69.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
5. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Remarks:
The transactions comprise: (i) 10,000 shares correcting an erroneous sale on August 28, 2026, and (ii) 30,113 shares representing separate new acquisitions executed on August 28, 2026, and August 31, 2026.
Opaleye Management, Inc., By: /s/ James Silverman, President08/31/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)