SOPHiA GENETICS (SOPH) CPO sells 380 shares to cover RSU taxes

Rhea-AI Filing Summary

SOPHiA GENETICS SA’s Chief People Officer, Manuela Valente, reported a small tax-related share sale. On May 19, 2026, she sold 380 Ordinary Shares at a weighted average price of $4.5985 per share, in open-market transactions.

The footnotes explain that these shares were sold solely to cover tax withholding obligations from restricted stock units that vested on May 18, 2026. The transactions were executed under a pre-established Rule 10b5-1(c) trading plan and are not discretionary trades. After the sale, she directly holds 214,691 Ordinary Shares.

Insider Trade Summary 10b5-1

Net Seller: 380 shares ($1,747)

Net Sell 1 txn

Insider Valente Manuela

Role Chief People Officer

Sold 380 shs ($2K)

Type	Security	Shares	Price	Value
Sale	Ordinary Shares	380	$4.5985	$2K

Holdings After Transaction: Ordinary Shares — 214,691 shares (Direct, null)

Footnotes (1)

1. Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on May 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.54 to $4.65, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Key Figures

Shares sold: 380 shares Weighted average sale price: $4.5985 per share Post-transaction holdings: 214,691 shares +1 more

4 metrics

Shares sold 380 shares Open-market sale on May 19, 2026

Weighted average sale price $4.5985 per share Ordinary Shares sold May 19, 2026

Post-transaction holdings 214,691 shares Ordinary Shares held directly after sale

Sale price range $4.54–$4.65 per share Multiple transactions included in Form 4

Key Terms

Rule 10b5-1(c) trading plan, restricted stock units, weighted average price

3 terms

Rule 10b5-1(c) trading plan regulatory

"These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person"

A Rule 10b5-1(c) trading plan is a legally defined, pre-set schedule that lets company insiders automatically buy or sell stock at specified times or under set formulas when they are not in possession of undisclosed, sensitive information. Think of it like an automatic payment plan for trades: because the instructions are written in advance, trades under the plan help protect insiders from allegations of trading on secret information and give investors clearer expectations about when insiders will transact, which can affect liquidity and perceived transparency.

restricted stock units financial

"obligations arising in connection with the vesting of restricted stock units on May 18, 2026"

Restricted stock units are a type of company reward where employees are promised shares of stock, but they only fully own these shares after meeting certain conditions, like staying with the company for a set time. They matter because they can become valuable assets and are often used to motivate employees to help the company succeed.

weighted average price financial

"The price reported in Column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Valente Manuela

(Last) (First) (Middle)

C/O SOPHIA GENETICS SA

LA PIECE 12

(Street)

ROLLE 1180

(City) (State) (Zip)

SWITZERLAND

(Country)

2. Issuer Name and Ticker or Trading Symbol
SOPHiA GENETICS SA [ SOPH ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
05/19/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares	05/19/2026		S		380(1)	D	$4.5985(2)	214,691	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on May 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.54 to $4.65, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Remarks:

	/s/ Elimara Brunetto as Attorney-in-fact for Manuela Valente	05/20/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transaction did SOPH’s Chief People Officer report?

SOPHiA GENETICS SA’s Chief People Officer, Manuela Valente, reported selling 380 Ordinary Shares. The sale occurred on May 19, 2026 at a weighted average price of $4.5985 per share in open-market transactions disclosed in a Form 4 filing.

Why did Manuela Valente sell SOPH shares in this Form 4 filing?

The 380 shares were sold to satisfy tax withholding obligations from vesting restricted stock units on May 18, 2026. Footnotes state the sale was purely for tax purposes rather than discretionary trading, clarifying the motivation behind the transaction.

Was the SOPH insider sale made under a Rule 10b5-1 plan?

Yes. The filing states the sales were effected under a pre-established Rule 10b5-1(c) trading plan. Such plans are set up in advance and automate trades, reducing the significance of trade timing as an indicator of the insider’s current market view.

How many SOPH shares does the insider hold after this transaction?

After selling 380 shares, Manuela Valente directly holds 214,691 Ordinary Shares of SOPHiA GENETICS SA. This indicates the reported sale is very small compared with her remaining position, suggesting it is a routine tax-related event rather than a major stake change.

What price range did the SOPH shares sell for in this Form 4?

The weighted average sale price was $4.5985 per share. Footnotes note the 380 shares were sold in multiple trades at prices ranging from $4.54 to $4.65, inclusive, with full trade-by-trade details available upon written request.