Welcome to our dedicated page for SPRUCE BIOSCIENCES SEC filings (Ticker: SPRB), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Spruce Biosciences filings document the regulatory, financing and governance record of a late-stage biopharmaceutical company developing TA-ERT for Sanfilippo Syndrome Type B (MPS IIIB). Form 8-K disclosures cover material agreements, including loan and security arrangements, at-the-market equity sale agreements, collaboration and license matters, and furnished clinical data updates related to the TA-ERT program.
Proxy materials describe shareholder voting matters, director elections, board committee changes, executive compensation and equity incentive plan matters. The filing record also includes capital-structure disclosures tied to common stock, equity awards, financing arrangements, risk factors and public-company governance.
Spruce Biosciences, Inc. has a significant shareholder group led by AIGH Capital Management LLC and related entities and person Orin Hirschman. These reporting persons collectively report beneficial ownership of 250,000 shares of Spruce Biosciences common stock, representing 9.1% of the outstanding class.
The reporting persons state they have sole voting power and sole dispositive power over 250,000 shares, with no shared voting or dispositive power. The ownership is reported jointly by AIGH Capital Management LLC, AIGH Investment Partners LLC, and Mr. Hirschman, who is managing member or president of the investment entities.
Spruce Biosciences, Inc. appointed Adrian Quartel, M.D., FFPM as Chief Medical Officer on July 27, 2026, replacing Interim Chief Medical Officer Dr. Kirk Ways, who remains on the Board of Directors. Quartel has more than 25 years of international pharmaceutical experience across clinical development, pharmacovigilance, and medical affairs.
He previously served as Chief Medical Officer at Zevra Therapeutics, Acer Therapeutics, and Adamas Pharmaceuticals. Earlier, at BioMarin Pharmaceutical, he led global medical affairs and helped launch six treatments for rare diseases and genetic disorders, including the enzyme replacement therapies NAGLAZYME and Brineura. Quartel holds an M.D. from Erasmus University Medical School and a postgraduate specialization in pharmaceutical medicine, and is board certified by the UK General Medical Council in pharmaceutical medicine.
SPRUCE BIOSCIENCES, INC. Chief Executive Officer Javier B. Szwarcberg acquired 266 shares of common stock at $4.5305 per share through the company’s 2020 Employee Stock Purchase Plan. This grant increased his direct holdings to 19,270 shares, reflecting routine compensation-related share accumulation rather than an open-market trade.
Spruce Biosciences director Daniel K. Spiegelman received a grant of stock options for 1,700 shares of Common Stock. The options have an exercise price of 52.7000 per share and expire on May 20, 2036. Following this grant, he holds 1,700 derivative securities directly.
The options vest on the first anniversary of the grant date, with full vesting no later than the company’s 2027 annual stockholder meeting, subject to his continuous service under the 2020 Equity Incentive Plan. The award will also vest in full upon a Change in Control as defined in that plan.
Spruce Biosciences director Camilla V. Simpson received a grant of stock options covering 1,700 shares of common stock. The options have an exercise price of $52.70 per share and expire on May 20, 2036. They generally vest on the first anniversary of the grant or by the company’s 2027 annual stockholder meeting, subject to continuous service, with full vesting upon a Change in Control.
SPRUCE BIOSCIENCES, INC. Executive Chairman Michael G. Grey received a grant of stock options covering 1,700 shares of common stock at an exercise price of $52.70 per share. These options vest on the first anniversary of the grant date, will in any case be fully vested by the company’s 2027 annual stockholder meeting, and vest in full upon a Change in Control, all subject to his continuous service under the 2020 Equity Incentive Plan.
Spruce Biosciences director Percival Barretto-Ko received a grant of stock options covering 1,700 shares of Common Stock. The options have an exercise price of $52.70 per share and expire on May 20, 2036.
The grant vests on the first anniversary of the grant date and in any case will be fully vested by the company's 2027 annual stockholder meeting, subject to the director's continuous service under the 2020 Equity Incentive Plan. The options also vest in full upon a Change in Control.
Spruce Biosciences director Keli Walbert received a new stock option grant. The Form 4 shows an award of 1,700 stock options for common stock at an exercise price of $52.70 per share, with 1,700 derivative securities held after the transaction.
The options vest on the first anniversary of the grant date and will in any case be fully vested by the company’s 2027 annual stockholder meeting, subject to continuous service. They also vest in full upon a change in control. This is a compensation-related grant, not an open-market purchase or sale.
Spruce Biosciences, Inc. held its 2026 Annual Meeting of Stockholders on May 21, 2026 in virtual format. As of the March 24, 2026 record date, 1,372,278 common shares were outstanding, and 903,893 shares, or about 65.86%, were represented, establishing a quorum.
Stockholders elected three Class III directors—Michael Grey, Camilla V. Simpson and Javier Szwarcberg—to serve until the 2029 annual meeting. They also ratified BDO USA, P.C. as independent auditor for the year ending December 31, 2026 and approved, on an advisory basis, the compensation of named executive officers.
In addition, stockholders indicated a preference for holding an advisory vote on executive compensation every year. The company plans to include an annual, non-binding say‑on‑pay vote in its proxy materials until the next required frequency vote, which must occur no later than the 2032 annual meeting.
Spruce Biosciences, Inc. ownership disclosure: a group of Citadel-related reporting persons jointly report beneficial ownership positions in the issuer's Common Stock. The filing states Citadel Advisors LLC, Citadel Advisors Holdings LP and Citadel GP LLC each may beneficially own 69,999 shares, and Kenneth Griffin may beneficially own 70,065 shares.
The filing cites 1,372,278 Shares outstanding as of March 24, 2026 and reports the listed holdings represent 5.1% of the class for the primary holders named. Shared voting and dispositive power is reported for those positions.