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[S-8] Spero Therapeutics, Inc. Employee Benefit Plan Registration

Filing Impact
(No impact)
Filing Sentiment
(Neutral)
Form Type
S-8
Rhea-AI Filing Summary

Spero Therapeutics registered an additional 3,000,000 shares of common stock under its 2017 Stock Incentive Plan, as amended, representing an increase in shares reserved for employee awards. The registration statement incorporates by reference prior Form S-8 filings for the same plan and includes key exhibits such as the amended plan, forms of award agreements, counsel opinion and the independent auditor's consent.

Spero Therapeutics ha registrato ulteriori 3.000.000 azioni ordinarie ai sensi del suo Piano di Incentivazione Azionaria 2017, così modificato, aumentando le azioni riservate per i riconoscimenti ai dipendenti. La dichiarazione di registrazione incorpora per riferimento le precedenti presentazioni sul modulo S-8 relative allo stesso piano e include allegati principali quali il piano modificato, i moduli dei contratti di assegnazione, il parere legale e il consenso del revisore indipendente.

Spero Therapeutics registró 3.000.000 acciones ordinarias adicionales bajo su Plan de Incentivos en Acciones 2017, según enmendado, aumentando las acciones reservadas para premios a empleados. La declaración de registro incorpora por referencia las presentaciones previas en el Formulario S-8 del mismo plan e incluye anexos clave como el plan enmendado, los modelos de acuerdos de adjudicación, el dictamen legal y el consentimiento del auditor independiente.

Spero Therapeutics는 자사의 2017년 주식 인센티브 플랜(수정본)에 따라 보통주 3,000,000주를 추가로 등록하여 직원 보상용으로 예약된 주식 수를 늘렸습니다. 등록명세서는 동일한 플랜에 대한 이전 Form S-8 제출을 참조로 포함하며, 수정된 플랜, 수상 계약서 양식, 법무 의견서 및 독립 감사인의 동의서 등 주요 첨부문서를 포함합니다.

Spero Therapeutics a enregistré 3 000 000 actions ordinaires supplémentaires dans le cadre de son plan d'intéressement en actions 2017, tel que modifié, augmentant ainsi le nombre d'actions réservées aux attributions aux employés. La déclaration d'enregistrement incorpore par référence les dépôts antérieurs au formulaire S-8 relatifs au même plan et comprend des pièces essentielles telles que le plan modifié, les modèles de conventions d'attribution, l'avis du conseil juridique et le consentement de l'auditeur indépendant.

Spero Therapeutics hat zusätzlich 3.000.000 Stammaktien im Rahmen seines 2017 Aktienanreizplans, in der geänderten Fassung registriert, wodurch die für Mitarbeiterzuwendungen reservierten Aktien erhöht wurden. Die Registrierungserklärung nimmt frühere Form S-8-Einreichungen für denselben Plan durch Verweis auf und enthält wesentliche Anlagen wie den geänderten Plan, Muster der Zuwendungsvereinbarungen, die Rechtsmeinung und die Zustimmung des unabhängigen Abschlussprüfers.

Positive
  • Registered 3,000,000 additional shares under the 2017 Stock Incentive Plan, increasing the pool for employee awards.
  • Filing includes counsel opinion and PwC consent, indicating completion of standard legal and accounting reviews and required exhibits.
Negative
  • None.

Insights

Routine equity registration to support employee compensation; limited immediate investor impact.

The filing registers 3,000,000 additional common shares for issuance under the company’s 2017 Stock Incentive Plan, which permits future grants to employees and service providers. The use of incorporation by reference to prior Form S-8s and inclusion of legal and audit exhibits (counsel opinion and PwC consent) indicate a standard, procedural filing to ensure shares are available for compensation programs. Impact on capital structure depends on future awards; the filing itself is administrative.

Board-authorized amendment expands the equity pool and follows standard governance procedures.

The registration statement documents an increase in the reserve under the 2017 Stock Incentive Plan and lists supporting exhibits including the amended plan and forms of option and RSU agreements. The filing also shows executed powers of attorney and board/member signatures, reflecting typical corporate approvals for employee equity programs. As a procedural governance action, the filing is not materially transformative on its own.

Spero Therapeutics ha registrato ulteriori 3.000.000 azioni ordinarie ai sensi del suo Piano di Incentivazione Azionaria 2017, così modificato, aumentando le azioni riservate per i riconoscimenti ai dipendenti. La dichiarazione di registrazione incorpora per riferimento le precedenti presentazioni sul modulo S-8 relative allo stesso piano e include allegati principali quali il piano modificato, i moduli dei contratti di assegnazione, il parere legale e il consenso del revisore indipendente.

Spero Therapeutics registró 3.000.000 acciones ordinarias adicionales bajo su Plan de Incentivos en Acciones 2017, según enmendado, aumentando las acciones reservadas para premios a empleados. La declaración de registro incorpora por referencia las presentaciones previas en el Formulario S-8 del mismo plan e incluye anexos clave como el plan enmendado, los modelos de acuerdos de adjudicación, el dictamen legal y el consentimiento del auditor independiente.

Spero Therapeutics는 자사의 2017년 주식 인센티브 플랜(수정본)에 따라 보통주 3,000,000주를 추가로 등록하여 직원 보상용으로 예약된 주식 수를 늘렸습니다. 등록명세서는 동일한 플랜에 대한 이전 Form S-8 제출을 참조로 포함하며, 수정된 플랜, 수상 계약서 양식, 법무 의견서 및 독립 감사인의 동의서 등 주요 첨부문서를 포함합니다.

Spero Therapeutics a enregistré 3 000 000 actions ordinaires supplémentaires dans le cadre de son plan d'intéressement en actions 2017, tel que modifié, augmentant ainsi le nombre d'actions réservées aux attributions aux employés. La déclaration d'enregistrement incorpore par référence les dépôts antérieurs au formulaire S-8 relatifs au même plan et comprend des pièces essentielles telles que le plan modifié, les modèles de conventions d'attribution, l'avis du conseil juridique et le consentement de l'auditeur indépendant.

Spero Therapeutics hat zusätzlich 3.000.000 Stammaktien im Rahmen seines 2017 Aktienanreizplans, in der geänderten Fassung registriert, wodurch die für Mitarbeiterzuwendungen reservierten Aktien erhöht wurden. Die Registrierungserklärung nimmt frühere Form S-8-Einreichungen für denselben Plan durch Verweis auf und enthält wesentliche Anlagen wie den geänderten Plan, Muster der Zuwendungsvereinbarungen, die Rechtsmeinung und die Zustimmung des unabhängigen Abschlussprüfers.

As filed with the Securities and Exchange Commission on August 12, 2025

Registration No. 333-   

 

 
 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

 

 

SPERO THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

 

 

 

Delaware   46-4590683

(State or other jurisdiction of

incorporation or organization)

 

(I.R.S. Employer

Identification No.)

675 Massachusetts Avenue, 14th Floor

Cambridge, Massachusetts

  02139
(Address of Principal Executive Offices)   (Zip Code)

SPERO THERAPEUTICS, INC. 2017 STOCK INCENTIVE PLAN, AS AMENDED

(Full title of the plan)

Esther Rajavelu, President, Chief Executive Officer, Chief Financial Officer and Treasurer

Spero Therapeutics, Inc.

675 Massachusetts Avenue, 14th Floor

Cambridge, Massachusetts 02139

(Name and address of agent of service)

(857) 242-1600

(Telephone number, including area code, of agent for service)

 

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer      Accelerated filer  
Non-accelerated filer      Smaller reporting company  
     Emerging growth company  

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

 

 
 


EXPLANATORY NOTE

This registration statement registers an aggregate of 3,000,000 additional shares of common stock of Spero Therapeutics, Inc. (the “Registrant”) reserved under the Spero Therapeutics, Inc. 2017 Stock Incentive Plan, as amended (the “2017 Plan”), representing an increase of 3,000,000 shares reserved under the 2017 Plan effective June 12, 2025. This registration statement registers additional securities of the same class as other securities for which a registration statement filed on Form S-8 relating to the 2017 Plan has previously been filed and is effective. This registration statement incorporates by reference the contents of (i) the registration statement on Form S-8 (File No. 333-222060), filed with the Securities and Exchange Commission on December 14, 2017 by the Registrant, (ii) the registration statement on Form S-8 (File No.  333-230281), filed with the Securities and Exchange Commission on March 14, 2019 by the Registrant, (iii) the registration statement on Form S-8 (File No.  333-237283), filed with the Securities and Exchange Commission on March 19, 2020 by the Registrant, (iv) the registration statement on Form S-8 (File No.  333-254173), filed with the Securities and Exchange Commission on March 11, 2021 by the Registrant, (v) the registration statement on Form S-8 (File No.  333-259662), filed with the Securities and Exchange Commission on September 20, 2021 by the Registrant, (vi) the registration statement on Form S-8 (File No.  333-268344), filed with the Securities and Exchange Commission on November 14, 2022 by the Registrant, (vii) the registration statement on Form S-8 (File No.  333-275514), filed with the Securities and Exchange Commission on November 13, 2023 by the Registrant, and (viii) the registration statement on Form S-8 (File No.  333-281245), filed with the Securities and Exchange Commission on August 5, 2024 by the Registrant, in each case, except for Item 8, Exhibits.


Item 8. Exhibits.

 

Exhibit
Number
  

Exhibit Description

   Filed
Herewith
     Incorporated by
Reference
herein from
Form or
Schedule
    Filing Date      SEC File/
Reg. Number
 
 4.1    Form of Common Stock Certificate of Registrant.        

Form S-1

(Exhibit 4.1

 

    10/6/2017        333-220858  
 4.2    Amended and Restated Certificate of Incorporation of the Registrant.        

Form 8-K

(Exhibit 3.1

 

    11/6/2017        001-38266  
 4.3    Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant.        

Form 8-K

(Exhibit 3.1

 

    8/18/2021        001-38266  
 4.4    Amended and Restated Bylaws of the Registrant.        

Form 10-Q

(Exhibit 3.1

 

    11/13/2023        001-38266  
 5.1    Opinion of Wilmer Cutler Pickering Hale and Dorr LLP.      X          
23.1    Consent of PricewaterhouseCoopers LLP, independent registered public accounting firm.      X          
23.2    Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in opinion of counsel filed as Exhibit 5.1).      X          
24.1    Power of Attorney (set forth on the signature page of this registration statement).      X          
99.1    2017 Stock Incentive Plan, as amended.        

Form 10-Q

(Exhibit 10.1

 

    8/12/2025        001-38266  
99.2    Form of Stock Option Agreement under the 2017 Stock Incentive Plan, as amended.        

Form S-8

(Exhibit 4.6

 

    9/20/2021        333-259662  
99.3    Form of Restricted Stock Unit Agreement under the 2017 Stock Incentive Plan, as amended.        

Form 8-K

(Exhibit 10.1

 

    8/30/2021        001-38266  
107    Filing Fee Table.      X          


SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on August 12, 2025.

 

SPERO THERAPEUTICS, INC.
By:   /s/ Esther Rajavelu
  Esther Rajavelu
  President, Chief Executive Officer, Chief Financial Officer and Treasurer

POWER OF ATTORNEY AND SIGNATURES

Each person whose signature appears below constitutes and appoints Esther Rajavelu and Timothy Keutzer, and each of them singly, his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them singly, for him or her and in his or her name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of Spero Therapeutics, Inc., and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.


Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

 

Signature    Title   Date

/s/ Esther Rajavelu

Esther Rajavelu

  

President, Chief Executive Officer, Chief Financial Officer and Treasurer

(Principal Executive Officer, Principal Financial Officer and Principal Accounting Officer)

  August 12, 2025

/s/ Frank E. Thomas

Frank E. Thomas

   Chairman   August 12, 2025

/s/ Milind Deshpande, Ph.D.

Milind Deshpande, Ph.D.

   Director   August 12, 2025

/s/ Scott Jackson

Scott Jackson

   Director   August 12, 2025

/s/ Ankit Mahadevia, M.D.

Ankit Mahadevia, M.D.

   Director   August 12, 2025

/s/ John C. Pottage, M.D.

John C. Pottage, M.D.

   Director   August 12, 2025

/s/ Cynthia Smith

Cynthia Smith

   Director   August 12, 2025

/s/ Kathleen Tregoning

Kathleen Tregoning

   Director   August 12, 2025

/s/ Patrick Vink, M.D.

Patrick Vink, M.D.

   Director   August 12, 2025

FAQ

What did Spero Therapeutics (SPRO) register on Form S-8?

The company registered an aggregate of 3,000,000 additional shares of common stock for issuance under its 2017 Stock Incentive Plan, as amended.

Does this registration change the total number of shares available under the plan?

This registration statement registers an increase of 3,000,000 shares reserved under the 2017 Stock Incentive Plan; the filing does not state the new total reserve.

What exhibits are included with the S-8 filing for SPRO?

Exhibits include the 2017 Stock Incentive Plan, as amended, forms of stock option and restricted stock unit agreements, counsel opinion (Exhibit 5.1), PwC consent (Exhibit 23.1) and the filing fee table (Exhibit 107).

What is Spero Therapeutics' filer status as shown in the filing?

The registrant identified itself as a non-accelerated filer and a smaller reporting company in the filing.

Who executed the registration statement for SPRO?

The registration statement was signed by Esther Rajavelu (President, Chief Executive Officer, Chief Financial Officer and Treasurer) and by the board members listed in the filing.
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