Vanguard Portfolio Management (SRPT) discloses 8.05% beneficial stake in Sarepta

Rhea-AI Filing Summary

Vanguard Portfolio Management LLC, on behalf of certain affiliated entities and accounts, reports updated passive ownership of Sarepta Therapeutics Inc. common stock on an amended Schedule 13G. As of June 30, 2026, Vanguard Portfolio Management is deemed to beneficially own 8,499,421 shares of Sarepta common stock, representing 8.05% of the class.

The filer has sole voting power over 121,951 shares and sole dispositive power over 8,499,421 shares, with no shared voting or dispositive power. The position includes shares held by Vanguard funds and other managed accounts for which Vanguard Portfolio Management or certain affiliates exercise voting and/or dispositive authority. Dividends and sale proceeds are attributable to those funds and clients, and no other single person has an interest in more than 5% of the class through these holdings.

Key Figures

Beneficial ownership: 8,499,421 shares Ownership percentage: 8.05% Sole voting power: 121,951 shares +1 more

4 metrics

Beneficial ownership 8,499,421 shares Sarepta Therapeutics common stock beneficially owned as of June 30, 2026

Ownership percentage 8.05% Percent of Sarepta Therapeutics common stock class beneficially owned

Sole voting power 121,951 shares Shares of Sarepta over which Vanguard Portfolio Management has sole voting power

Sole dispositive power 8,499,421 shares Shares of Sarepta over which Vanguard Portfolio Management has sole dispositive power

Key Terms

beneficially owned, sole dispositive power, sole voting power, Schedule 13G, +1 more

5 terms

beneficially owned financial

"reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

sole dispositive power financial

"Sole power to dispose or to direct the disposition of: 8499421"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

sole voting power financial

"Sole power to vote or to direct the vote: 121951"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Schedule 13G regulatory

"In accordance with SEC Release No. 34-39538 ... ownership reported on Schedule 13G"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

Investment Company Act of 1940 regulatory

"investment companies registered under the Investment Company Act of 1940 and other managed accounts"

A U.S. federal law that sets the rulebook for pooled investment vehicles such as mutual funds, exchange-traded funds and similar money managers, requiring them to register with regulators, disclose holdings and fees, limit conflicts of interest, and follow governance standards. It matters to investors because these protections and transparency rules act like a referee and scoreboard, helping people compare funds, trust that managers follow fair practices, and spot hidden costs or risks.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What percentage of Sarepta Therapeutics (SRPT) does Vanguard Portfolio Management report owning?

Vanguard Portfolio Management reports beneficial ownership of 8.05% of Sarepta Therapeutics’ common stock, representing 8,499,421 shares as of June 30, 2026, according to its amended Schedule 13G filing.

How many Sarepta Therapeutics (SRPT) shares does Vanguard Portfolio Management control voting for?

Vanguard Portfolio Management has sole voting power over 121,951 shares of Sarepta Therapeutics common stock and no shared voting power, based on the Schedule 13G/A ownership disclosure.

What is the total number of Sarepta Therapeutics (SRPT) shares Vanguard Portfolio Management can dispose of?

Vanguard Portfolio Management has sole dispositive power over 8,499,421 shares of Sarepta Therapeutics common stock and no shared dispositive power, meaning it can direct how those shares are sold or otherwise disposed of.

Which entities are included in Vanguard Portfolio Management’s Sarepta (SRPT) beneficial ownership report?

The reported beneficial ownership includes securities held by Vanguard Portfolio Management LLC, Vanguard Fiduciary Trust Company, Vanguard Global Advisers, LLC, and certain Vanguard funds and managed accounts over which these affiliates exercise voting or dispositive power.

Does any other investor hold more than 5% of Sarepta (SRPT) through Vanguard’s reported holdings?

No. The filing states that while Vanguard funds and managed accounts receive dividends and sale proceeds, no one other person's interest in the reported Sarepta securities exceeds 5% of the class.

Is Vanguard Portfolio Management’s Sarepta (SRPT) position reported as passive or activist?

The position is reported on Schedule 13G/A, which is used for passive beneficial ownership rather than activist intent, indicating a large investment stake without stated control-seeking purposes.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

Sarepta Therapeutics Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

803607100

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 803607100

1

Names of Reporting Persons

Vanguard Portfolio Management

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 121,951.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 8,499,421.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

8,499,421.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

8.05 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Portfolio Management LLC and the following affiliates of Vanguard Portfolio Management LLC or business divisions of such affiliates: Vanguard Fiduciary Trust Company and Vanguard Global Advisers, LLC. This Schedule 13G includes securities held by Vanguard funds, or sleeves thereof, over which Vanguard Portfolio Management LLC exercises dispositive power, in addition to securities held by clients over which the affiliates or business divisions of such affiliates indicated above exercise dispositive and/or voting power. This Schedule 13G does not include securities, if any, beneficially owned by other subsidiaries or affiliates of Vanguard Portfolio Management LLC, or business divisions of such subsidiaries whose ownership of securities is disaggregated from that of the reporting business unit in accordance with such release.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Sarepta Therapeutics Inc
(b)	Address of issuer's principal executive offices: 215 First Street, Suite 415, Cambridge, MA, 02142
Item 2.
(a)	Name of person filing: Vanguard Portfolio Management
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 803607100
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 8499421
(b)	Percent of class: 8.05 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 121951
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 8499421
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Vanguard Portfolio Management, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Vanguard Portfolio Management

Signature:	My Trieu-Gatt
Name/Title:	Authorized Signatory, Head of Global Fund Administration
Date:	07/31/2026