[Form 4] Tempus AI, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Tempus AI, Inc. insider Eric Lefkofsky reported stock sales in a Form 4 filing. On 11/24/2025, entities affiliated with him sold 33,250 and 133,000 shares of Class A common stock in open market transactions coded as sales. The weighted average price for these trades was $74.10 per share, with individual sales occurring between $74.00 and $74.49.

Following these transactions, the filing reports indirect beneficial ownership of 9,008,033 Class A shares through Gray Media, LLC and 16,571,469 Class A shares through Blue Media, LLC, along with additional indirect holdings through several family and charitable entities. The trades were made pursuant to a pre-established Rule 10b5-1 trading plan adopted on March 4, 2025.

Insights

Equity Ownership and Governance Analyst

CEO/Chair and 10% owner sells shares under a 10b5-1 plan while retaining very large indirect holdings.

The filing reports open-market sales of Class A common stock by the CEO, Chairman, and 10% owner of Tempus AI, Inc.. Two transactions on 11/24/2025 disposed of 33,250 and 133,000 shares, both coded "S" for sales, at a weighted average price of about $ 74.1 per share, executed under a Rule 10b5‑1 trading plan adopted on March 4, 2025. These sales reduced positions held indirectly through Gray Media, LLC and Blue Media, LLC.

Despite these sales, the reporting person continues to show very large beneficial ownership across several entities, including multi‑million‑share positions through Gray Media, Blue Media, and other affiliated vehicles, plus additional holdings via a family GRAT and foundation. The Rule 10b5‑1 designation signals that these trades followed a pre‑set plan rather than ad hoc timing. That framework can limit concerns about opportunistic trading, while still reflecting incremental diversification of personal holdings.

Key items to watch are any pattern of continued sales from these entities and any future changes in the reporting person’s role as Director, CEO, Chairman, or 10% owner. Subsequent Form 4 filings will show whether these transactions are isolated or part of a larger, ongoing disposition program over the coming quarters.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

LEFKOFSKY ERIC P

(Last) (First) (Middle)

C/O TEMPUS AI, INC.

600 WEST CHICAGO AVENUE, SUITE 510

(Street)

CHICAGO IL 60654

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Tempus AI, Inc. [ TEM ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	X	10% Owner
X	Officer (give title below)		Other (specify below)
	CEO and Chairman

3. Date of Earliest Transaction (Month/Day/Year)
11/24/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Class A Common Stock	11/24/2025		S(1)		33,250	D	$74.1(2)	9,008,033	I	By Gray Media, LLC(3)
Class A Common Stock	11/24/2025		S(1)		133,000	D	$74.1(2)	16,571,469	I	By Blue Media, LLC(3)
Class A Common Stock								2,003,213	D
Class A Common Stock								406	I	By 346 Long LLC(3)
Class A Common Stock								10,000,000	I	Lefkofsky Family 2025 GRAT(3)
Class A Common Stock								206	I	By Black Media, LLC(3)
Class A Common Stock								832,131	I	By Lefkofsky Family Foundation(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 4, 2025.

2. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.00 to $74.49 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

3. The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC and (iii) a trustee of Lefkofsky Family Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT.

	/s/ Andrew Polovin, Attorney-in-Fact	11/25/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Tempus AI (TEM) disclose in this Form 4?

The Form 4 reports that on 11/24/2025, entities affiliated with Eric Lefkofsky sold 33,250 and 133,000 shares of Tempus AI Class A common stock in open market sales.

At what price were Tempus AI (TEM) shares sold in the reported insider trades?

The filing reports a weighted average price of $74.10 per share, with individual sale prices ranging from $74.00 to $74.49 for the Tempus AI Class A common stock sold.

How many Tempus AI (TEM) shares does the reporting person still beneficially own after the sales?

After the reported transactions, the filing shows indirect beneficial ownership of 9,008,033 Class A shares through Gray Media, LLC and 16,571,469 Class A shares through Blue Media, LLC, along with additional indirect holdings through other family and charitable entities.

Was the Tempus AI (TEM) insider sale made under a Rule 10b5-1 trading plan?

Yes. The filing states that the transactions were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 4, 2025.

What is the role of the reporting person at Tempus AI (TEM)?

The reporting person is identified as a Director, 10% Owner, and Officer of Tempus AI, serving as CEO and Chairman.

How is the insider’s ownership in Tempus AI (TEM) held according to the Form 4?

The Form 4 describes the reporting person’s Tempus AI holdings as indirectly owned through entities such as Gray Media, LLC, Blue Media, LLC, 346 Long LLC, the Lefkofsky Family 2025 GRAT, and the Lefkofsky Family Foundation.