Tango Therapeutics reports a Schedule 13G/A showing Adage Capital and affiliated reporting persons beneficially own 12,809,485 shares of Common Stock, equal to 8.98% of the class. The percentage is calculated using 142,688,851 shares outstanding as of February 26, 2026.
The statement attributes shared voting and dispositive power of 12,809,485 shares to Adage Capital Management, L.P., with reporting by Robert Atchinson and Phillip Gross. The filing is signed on May 13, 2026.
Positive
None.
Negative
None.
Insights
Adage holds a visible minority stake of 8.98% in Tango Therapeutics.
Adage Capital Management, L.P. (through affiliated entities) is shown with shared voting and dispositive power over 12,809,485 shares, representing 8.98% of the outstanding common stock as of February 26, 2026.
This filing is a passive ownership disclosure under Schedule 13G/A; voting and disposition are reported as shared. Subsequent filings would be required if the nature of ownership or intent changes.
Filing structure and attribution follow Schedule 13G/A conventions with named managing members.
The statement attributes holdings to ACP as the direct holder and to ACM, ACA, ACPGP, and managing members Robert Atchinson and Phillip Gross for reporting purposes. The cover-page rows show shared voting/dispositive power of 12,809,485 shares.
Absent any alternative language, this remains a regulatory disclosure of beneficial ownership; any change in intent or percentage crossing reporting thresholds would prompt an amended filing.
Key Figures
Shares beneficially owned:12,809,485 sharesPercent of class:8.98%Shares outstanding (as of):142,688,851 shares+3 more
6 metrics
Shares beneficially owned12,809,485 sharesAmount reported as beneficially owned by Adage/Reporting Persons
Percent of class8.98%Calculated using 142,688,851 shares outstanding as of February 26, 2026
Shares outstanding (as of)142,688,851 sharesOutstanding common stock as of February 26, 2026 per company 2025 Form 10-K
Shared voting power12,809,485 sharesReported shared voting power on cover page
Shared dispositive power12,809,485 sharesReported shared dispositive power on cover page
Filing signature dateMay 13, 2026Date shown with signatures on the Schedule 13G/A amendment
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
Beneficial ownershipregulatory
"Amount beneficially owned: The information required by Item 4(a)"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
Shared dispositive powerregulatory
"Shared Dispositive Power 12,809,485.00"
Cover page Row 9regulatory
"The information required by Item 4(a) is set forth in Row 9 of the cover page"
See more from StockTitan in Google Search and AI answers.Adds StockTitan as a preferred source · opens Google
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)
Tango Therapeutics, Inc.
(Name of Issuer)
Common Stock, par value $0.001 per share
(Title of Class of Securities)
87583X109
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
87583X109
1
Names of Reporting Persons
Adage Capital Management, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
12,809,485.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
12,809,485.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
12,809,485.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
8.98 %
12
Type of Reporting Person (See Instructions)
IA, PN
SCHEDULE 13G
CUSIP Number(s):
87583X109
1
Names of Reporting Persons
Robert Atchinson
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
12,809,485.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
12,809,485.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
12,809,485.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
8.98 %
12
Type of Reporting Person (See Instructions)
HC, IN
SCHEDULE 13G
CUSIP Number(s):
87583X109
1
Names of Reporting Persons
Phillip Gross
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
12,809,485.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
12,809,485.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
12,809,485.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
8.98 %
12
Type of Reporting Person (See Instructions)
HC, IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Tango Therapeutics, Inc.
(b)
Address of issuer's principal executive offices:
201 Brookline Ave., Suite 901, Boston, MA 02215
Item 2.
(a)
Name of person filing:
This statement is filed by:
(i) Adage Capital Management, L.P., a Delaware limited partnership ("ACM"), as the investment manager of Adage Capital Partners, L.P., a Delaware limited partnership ("ACP"), with respect to the shares of common stock, par value $0.001 per share ("Common Stock") of Tango Therapeutics, Inc., a Delaware corporation (the "Company") directly held by ACP;
(ii) Robert Atchinson ("Mr. Atchinson"), as (1) managing member of Adage Capital Advisors, L.L.C., a limited liability company organized under the laws of the State of Delaware ("ACA"), managing member of Adage Capital Partners GP, L.L.C., a limited liability company organized under the laws of the State of Delaware ("ACPGP"), general partner of ACP and (2) managing member of Adage Capital Partners LLC, a Delaware limited liability company ("ACPLLC"), general partner of ACM, with respect to the shares of Common Stock directly held by ACP; and
(iii) Phillip Gross ("Mr. Gross"), as (1) managing member of ACA, managing member of ACPGP and (2) managing member of ACPLLC, general partner of ACM, with respect to the shares of Common Stock directly held by ACP.
The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." Any disclosures herein with respect to persons other than the Reporting Persons are made on information and belief after making inquiry to the appropriate party.
The filing of this statement should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of the securities reported herein.
(b)
Address or principal business office or, if none, residence:
The address of the business office of each of the Reporting Persons is 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116.
(c)
Citizenship:
ACM is a limited partnership organized under the laws of the State of Delaware. Messrs. Gross and Atchinson are citizens of the United States.
(d)
Title of class of securities:
Common Stock, par value $0.001 per share
(e)
CUSIP No.:
87583X109
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 142,688,851 shares of Common Stock outstanding as of February 26, 2026, as reported in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the Securities and Exchange Commission on March 5, 2026.
(b)
Percent of class:
8.98%
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(ii) Shared power to vote or to direct the vote:
The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(iii) Sole power to dispose or to direct the disposition of:
The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(iv) Shared power to dispose or to direct the disposition of:
The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
See Item 2(a).
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Adage Capital Management, L.P.
Signature:
/s/ Robert Atchinson
Name/Title:
By: Adage Capital Partners LLC, its General Partner, By: Robert Atchinson, its Managing Member
What stake does Adage Capital report in Tango Therapeutics (TNGX)?
Adage reports ownership of 12,809,485 shares, or 8.98% of the class. This percentage uses 142,688,851 shares outstanding as of February 26, 2026, per the company’s 2025 Form 10-K referenced in the filing.
Who are the reporting persons on the Schedule 13G/A for TNGX?
The filing is reported by Adage Capital Management, L.P., Robert Atchinson, and Phillip Gross. ACP is the direct holder; ACM, ACA, ACPLLC and related managing members are named for reporting and attribution purposes.
What voting and dispositive powers are reported by Adage for TNGX shares?
The cover-page shows shared voting power of 12,809,485 shares and shared dispositive power of 12,809,485 shares. Sole voting and sole dispositive powers are reported as zero for the named reporting persons.
Which outstanding share count is used to calculate the 8.98% in the filing?
The percentage is based on 142,688,851 shares outstanding as of February 26, 2026. That figure is taken from the company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025, cited in the Schedule 13G/A.
When was the Schedule 13G/A signed for Tango Therapeutics?
The signing dates shown in the filing are May 13, 2026. Signatures include Robert Atchinson signing on behalf of Adage Capital Partners LLC and individually, and Phillip Gross individually.
