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Tempest Therapeutics, Inc. filings document material-event disclosures for a clinical-stage biotechnology company developing CAR-T cell therapy and small-molecule product candidates. The company’s 8-K filings include Regulation FD presentations, press releases on TPST-2003 clinical data, annual financial results, business updates, and exhibits describing corporate presentations and pipeline activity.
The filing record also covers capital-structure and governance matters, including Nasdaq-listed common stock, Series A Junior Participating Preferred Purchase Rights, a limited-duration stockholder rights plan, equity incentive plan amendments, and listing-compliance notices. Material agreement disclosures include the completed acquisition of dual-targeting CAR-T assets and related common stock consideration.
Tempest Therapeutics reported first quarter 2026 results and highlighted rapid progress in its lead CAR‑T program, TPST‑2003. Positive interim data from partner‑run REDEEM‑1 and POEMS‑1 trials showed a 100% complete response rate among 15 efficacy‑evaluable, CAR‑T‑naïve patients with relapsed/refractory multiple myeloma or POEMS syndrome, with no Grade ≥3 CRS or ICANS reported in REDEEM‑1.
The company closed a strategic asset acquisition from Factor Bioscience and Erigen, adding next‑generation dual‑targeting CAR‑T assets, and selected Cincinnati Children’s AGCTC as lead manufacturing partner, which has received the TPST‑2003 lentiviral vector ahead of a planned U.S. registrational study. Tempest also announced a private placement of up to $6 million in common stock and warrants.
Financially, Tempest ended the quarter with $1.8 million in cash and cash equivalents. Net loss was $27.7 million, driven largely by $22.1 million of acquired in‑process R&D linked to the asset acquisition, $5.4 million in general and administrative expenses, and $0.1 million in research and development spending.
Tempest Therapeutics furnished an investor presentation and press release outlining updated clinical data for its lead dual-targeting CAR-T candidate TPST-2003.
Across two ongoing Phase 1/2 trials in relapsed/refractory multiple myeloma and POEMS syndrome, all 15 CAR-T-naïve efficacy-evaluable patients achieved complete responses. In REDEEM-1, 10 of 10 CAR-T-naïve multiple myeloma patients reached complete response using standard IMWG criteria. In POEMS-1, all five efficacy-evaluable patients achieved complete VEGF-based responses within two months of treatment.
Including a prior investigator-initiated trial, 44 patients have received TPST-2003. Among 29 CAR-T-naïve evaluable multiple myeloma patients with measurable disease at baseline, the overall response rate was 100%, with a median progression-free survival of 23.1 months across 24 patients and the same median in those with extramedullary disease. The safety profile showed no grade ≥3 cytokine release syndrome or ICANS in REDEEM-1, though four deaths occurred in the IIT, including two therapy-related pneumonias and two from disease progression. Tempest states these results support its objective of meeting with the FDA to discuss a potential U.S. registrational study for TPST-2003 later in 2026.
Tempest Therapeutics is registering 2,777,781 shares of common stock for resale by selling stockholders pursuant to registration rights granted in a March 20, 2026 private placement.
The registration covers (i) 462,964 issued shares, (ii) 925,927 shares issuable upon exercise of Series A Warrants, (iii) 925,927 shares issuable upon exercise of Series B Warrants, and (iv) 462,963 shares issuable upon exercise of Pre-Funded Warrants. The company will not receive proceeds from resale by the selling stockholders; the company will receive proceeds only from any cash exercise of the Common Warrants and nominal proceeds from cash exercise of the Pre-Funded Warrants. Shares outstanding were 14,344,034 as of March 30, 2026, and the Nasdaq closing price was $1.56 per share on April 8, 2026.
Tempest Therapeutics is registering for resale up to 8,268,495 shares of its common stock issued to sellers in the Asset Purchase Agreement. The registration covers shares issued in connection with the Acquisition and permits the named selling stockholders and their permitted transferees to offer or sell the Shares from time to time.
The prospectus states we will not receive any proceeds from resale by the selling stockholders. The percentage ownership calculations are based on 14,344,034 shares outstanding as of March 25, 2026. Sales may occur in public or private transactions, at prevailing market prices or negotiated prices.
Tempest Therapeutics, Inc. reported that Corporate Controller Justin Trojanowski received a grant of employee stock options for 22,000 shares of common stock. The options have an exercise price of $1.64 per share and expire on March 30, 2036.
According to the vesting terms, 25% of the options will vest on March 31, 2027, with the remaining options vesting in 36 equal monthly installments thereafter, contingent on his continued service. Following this grant, his reported holdings in these options total 22,000 derivative securities, all held directly.
Tempest Therapeutics, Inc. reported that Chief Financial Officer Nicholas Maestas received a grant of employee stock options covering 140,000 shares of common stock at an exercise price of $1.64 per share. These options expire on March 30, 2036 and are held as a direct ownership position.
According to the vesting terms, 25% of the total shares will vest on March 31, 2027, with the remaining shares vesting in 36 equal monthly installments thereafter, contingent on Maestas’s continued service. Following this grant, he holds 140,000 options in this award.
Tempest Therapeutics, Inc. received an updated ownership report from several Versant-managed funds on Schedule 13D/A Amendment No. 7. The amendment reflects dilution of their stakes after the company sold additional common shares.
Versant Venture Capital VI, L.P. now reports beneficial ownership of 16,149 shares, or 0.1% of Tempest’s common stock. Versant Vantage II, L.P. reports 162,972 shares, or 1.1%. Versant Venture Capital IV, L.P. reports 90,084 shares, or 0.6%, and Versant Side Fund IV, L.P. reports 567 shares. Versant Ventures IV, LLC reports 90,651 shares, or 0.6%. Percentages are based on 14,344,034 shares outstanding as of March 25, 2026, per Tempest’s Form 10-K.
Tempest Therapeutics, Inc. is registering the resale of up to 2,777,781 shares of its common stock by selling stockholders.
The registration covers shares issued in a March 20, 2026 private placement (including 462,964 issued shares, 925,927 Series A Warrant shares, 925,927 Series B Warrant shares and 462,963 Pre-Funded Warrant shares). The company will not receive proceeds from resale of these shares. Shares outstanding were 14,344,034 as of March 30, 2026.