STOCK TITAN

Twist Bioscience (TWST) CEO exercises options and sells shares

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Twist Bioscience CEO Emily M. Leproust reported option-related trades in Common Stock. She exercised employee stock options to acquire 9,671 shares at an exercise price of $8.82 per share, then sold 9,671 shares in open‑market transactions at prices around $65–66 per share under a pre‑arranged Rule 10b5‑1 trading plan. After these transactions she directly owns 858,887 shares of Common Stock and retains employee stock options, including a grant tied to 64,950 underlying shares with a $67.85 exercise price.

Positive

  • None.

Negative

  • None.
Insider Leproust Emily M.
Role Chief Executive Officer
Sold 9,671 shs ($631K)
Type Security Shares Price Value
Exercise Employee Stock Option (right to buy) 8,061 $0.00 --
Exercise Common Stock 8,061 $8.82 $71K
Sale Common Stock 7,910 $65.275 $516K
Sale Common Stock 151 $66.00 $10K
Exercise Employee Stock Option (right to buy) 1,610 $0.00 --
Exercise Common Stock 1,610 $8.82 $14K
Sale Common Stock 1,610 $65.01 $105K
holding Employee Stock Option (right to buy) -- -- --
holding Employee Stock Option (right to buy) -- -- --
holding Employee Stock Option (right to buy) -- -- --
holding Employee Stock Option (right to buy) -- -- --
Holdings After Transaction: Employee Stock Option (right to buy) — 141,208 shares (Direct, null); Common Stock — 866,948 shares (Direct, null)
Footnotes (1)
  1. The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on May 27, 2025. Represents the weighted average sales price per share. The shares sold at prices ranging from $65.00 to $65.06 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $65.00 to $65.87 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $66.00 to $66.01 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. The option is immediately exercisable. 25% of the shares subject to the option vested on September 1, 2016 and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. 20% of the shares subject to the option vested and became exercisable on October 31, 2019 and 1/60th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. 25% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. Represents performance stock options granted to the reporting person on September 1, 2020, that vested and became exercisable on December 19, 2022 as a result of the reporting person having met the applicable performance criteria. The option is immediately exercisable. 10% of the shares subject to the option vested on September 28, 2017, 15% of the shares subject to the option vested on September 28, 2018, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
Shares sold 9,671 shares Open-market Common Stock sales on April 21–22, 2026
Sale prices $65.01–$66.00 per share Reported transaction prices for Common Stock sales
Options exercise price $8.82 per share Exercise price for employee stock options converted into 9,671 shares
Shares after transactions 858,887 shares Direct Common Stock ownership following reported trades
Remaining option grant 64,950 underlying shares Employee stock option with $67.85 exercise price expiring August 31, 2030
Net share change 9,671 net shares sold NetBuySellShares from transaction summary (net-sell direction)
Additional option exercise 8,061 shares Common Stock acquired via option exercise on April 22, 2026
Rule 10b5-1 trading plan regulatory
"The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted..."
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average sales price financial
"Represents the weighted average sales price per share. The shares sold at prices ranging from $65.00 to $65.06 per share."
Employee Stock Option (right to buy) financial
"Employee Stock Option (right to buy)... underlying security title: Common Stock..."
performance stock options financial
"Represents performance stock options granted to the reporting person on September 1, 2020..."
exercise or conversion of derivative security financial
"transaction_code_description: Exercise or conversion of derivative security"
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Leproust Emily M.

(Last)(First)(Middle)
C/O TWIST BIOSCIENCE CORPORATION
681 GATEWAY BLVD.

(Street)
SOUTH SAN FRANCISCO CALIFORNIA 94080

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Twist Bioscience Corp [ TWST ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Chief Executive Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
04/21/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock04/21/2026M(1)1,610A$8.82860,497D
Common Stock04/21/2026S(1)1,610D$65.01(2)858,887D
Common Stock04/22/2026M(1)8,061A$8.82866,948D
Common Stock04/22/2026S(1)7,910D$65.275(3)859,038D
Common Stock04/22/2026S(1)151D$66(4)858,887D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Employee Stock Option (right to buy)$5.95 (5)09/28/2025Common Stock00D
Employee Stock Option (right to buy)$26.66 (6)11/18/2028Common Stock0266,539D
Employee Stock Option (right to buy)$23.33 (7)10/23/2029Common Stock0131,290D
Employee Stock Option (right to buy)$67.8512/19/202208/31/2030Common Stock64,95064,950(8)D
Employee Stock Option (right to buy)$8.8204/21/2026M1,610 (9)09/28/2027Common Stock1,610$0149,269D
Employee Stock Option (right to buy)$8.8204/22/2026M8,061 (9)09/28/2027Common Stock8,061$0141,208D
Explanation of Responses:
1. The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on May 27, 2025.
2. Represents the weighted average sales price per share. The shares sold at prices ranging from $65.00 to $65.06 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.
3. Represents the weighted average sales price per share. The shares sold at prices ranging from $65.00 to $65.87 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.
4. Represents the weighted average sales price per share. The shares sold at prices ranging from $66.00 to $66.01 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.
5. The option is immediately exercisable. 25% of the shares subject to the option vested on September 1, 2016 and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
6. 20% of the shares subject to the option vested and became exercisable on October 31, 2019 and 1/60th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
7. 25% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
8. Represents performance stock options granted to the reporting person on September 1, 2020, that vested and became exercisable on December 19, 2022 as a result of the reporting person having met the applicable performance criteria.
9. The option is immediately exercisable. 10% of the shares subject to the option vested on September 28, 2017, 15% of the shares subject to the option vested on September 28, 2018, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
Remarks:
/s/ Kendra Fox, as Attorney-in-Fact for Emily M. Leproust04/23/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Twist Bioscience (TWST) report for CEO Emily Leproust?

Twist Bioscience reported that CEO Emily Leproust exercised options for 9,671 Common Stock shares at $8.82 and sold 9,671 shares in open‑market transactions around $65–66. These trades were disclosed as part of a routine Form 4 insider transaction report.

How many Twist Bioscience (TWST) shares did the CEO sell and at what prices?

Emily Leproust sold 9,671 shares of Twist Bioscience Common Stock. Reported transaction prices included $65.01, $65.275 and $66.00 per share, with weighted average prices disclosed in the footnotes across narrow ranges between roughly $65.00 and $66.01 per share.

Did the Twist Bioscience (TWST) CEO exercise stock options in this Form 4 filing?

Yes. The CEO exercised employee stock options to acquire 9,671 Common Stock shares at an exercise price of $8.82 per share. Corresponding derivative entries show these employee stock options converting into Common Stock as part of the reported transactions on April 21 and April 22.

How many Twist Bioscience (TWST) shares does the CEO hold after these transactions?

After the reported trades, Emily Leproust directly holds 858,887 shares of Twist Bioscience Common Stock. This post‑transaction ownership figure comes from the Form 4 totals which reflect her remaining direct position following the option exercises and open‑market sales disclosed.

Were the Twist Bioscience (TWST) CEO’s stock sales under a Rule 10b5-1 plan?

Yes. A footnote states that the transactions were effected pursuant to a Rule 10b5‑1 trading plan adopted by the reporting person. Such plans are pre‑arranged trading programs designed to systematically sell shares over time under predetermined conditions.

What stock options remain for the Twist Bioscience (TWST) CEO after the reported trades?

The derivative summary shows remaining employee stock options, including one with a $67.85 exercise price tied to 64,950 underlying Common Stock shares expiring on August 31, 2030. Other options with various exercise prices and expiration dates are also listed with underlying share amounts.