[Form 4] Twist Bioscience Corp Insider Trading Activity

Rhea-AI Filing Summary

Dennis Cho, Senior Vice President, Chief Legal Officer & Corporate Secretary of Twist Bioscience Corp (TWST), reported a non-discretionary sale on 09/22/2025 to satisfy tax withholding for vested restricted stock units. The filing shows 233 shares disposed at $27.56 per share and the reporting person held 102,710 shares following the transaction. The sale is described as a company-mandated "sell to cover" tied to equity plan withholding, not a voluntary trade by the insider.

The Form 4 was signed on 09/24/2025 by an attorney-in-fact. No other transactions or derivative positions are reported in this filing.

Positive

• Insider retained substantial ownership: Reporting person holds 102,710 shares after the transaction, indicating continued alignment with shareholders
• Transaction was non-discretionary: Sale described as a company-mandated "sell to cover" for RSU tax withholding, reducing signaling of negative insider sentiment

Negative

• None.

Insights

Securities Analyst

TL;DR: Routine sell-to-cover for RSU tax withholding; small single transaction relative to holdings, neutral for shareholders.

The disposition of 233 shares at $27.56 appears to be a standard administrative sale to satisfy tax obligations arising from RSU vesting. The insider still beneficially owns 102,710 shares, indicating continued substantial ownership and alignment with shareholders. Because the filing explicitly states the sale was mandated by the issuer's election under its equity plans and not discretionary, this transaction carries no new information about the insider's view on company prospects.

Corporate Governance Expert

TL;DR: Administrative compliance action; reflects equity plan mechanics, not a change in governance or executive stance.

The Form 4 documents a compliance-driven sale to meet tax withholding from RSU vesting. The specificity that the sale was required under the issuer's election reduces concerns about opportunistic insider sales. The remaining beneficial ownership of 102,710 shares suggests ongoing executive stake. No governance issues, departures, or additional compensatory arrangements are disclosed in this filing.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Cho Dennis

(Last) (First) (Middle)

C/O TWIST BIOSCIENCE CORPORATION

681 GATEWAY BLVD

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Twist Bioscience Corp [ TWST ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	See Remarks

3. Date of Earliest Transaction (Month/Day/Year)
09/22/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	09/22/2025		S		233(1)	D	$27.56	102,710	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

Remarks:

Senior Vice President, Chief Legal Officer & Corporate Secretary

	/s/ Kendra Fox, as Attorney-in-Fact for Dennis Cho	09/24/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Dennis Cho report on the Form 4 for TWST?

The filing reports a sale of 233 shares on 09/22/2025 at $27.56 per share to cover tax withholding from vested RSUs.

Was the sale by the TWST insider discretionary?

No. The Form 4 states the sale was a company-mandated "sell to cover" to satisfy tax withholding obligations and did not represent a discretionary trade.

How many TWST shares does the reporting person own after the transaction?

The reporting person beneficially owned 102,710 shares following the reported transaction.

When was the Form 4 signed and filed for this TWST transaction?

The Form 4 was signed by an attorney-in-fact on 09/24/2025, reporting the transaction dated 09/22/2025.

Does the Form 4 show any derivative or option transactions for TWST?

No. The filing contains no reported derivative or option transactions; only the non-derivative sale of common stock is listed.