[Form 4] Twist Bioscience Corporation Insider Trading Activity

Rhea-AI Filing Summary

Paula Green, Senior Vice President of Human Resources at Twist Bioscience Corporation (TWST), reported a sale of company stock on 08/21/2025. The Form 4 shows 619 shares were disposed of at a price of $25.964 per share as a sell-to-cover transaction to satisfy tax withholding on vested Restricted Stock Units. After the transaction the reporting person beneficially owned 125,729 shares, which the filing notes includes shares acquired under the company Employee Stock Purchase Plan that were exempt under Rule 16b-3. The form was signed by an attorney-in-fact on 08/25/2025.

Positive

• Sale identified as a sell-to-cover, indicating the disposition was to satisfy tax withholding on vested RSUs rather than a discretionary trade
• Beneficial ownership remains substantial at 125,729 shares after the transaction
• ESP P shares explicitly noted as exempt under Rule 16b-3, clarifying compliance with insider-trading rules

Negative

• Reporting person disposed of 619 shares, which represents an insider sale disclosed publicly

Insights

Securities Analyst

TL;DR Routine sell-to-cover sale by an officer to satisfy tax withholding; not a discretionary market sale.

The transaction reported is a mandated sell-to-cover tied to RSU vesting rather than an open-market, discretionary sale. The number of shares sold (619) and the stated purpose reduce the likelihood this trade materially signals a change in the reporting person’s view of company prospects. The post-transaction beneficial ownership (125,729 shares) still reflects meaningful equity exposure, including ESPP shares acquired under exempt provisions.

Corporate Governance Expert

TL;DR Disclosure is consistent with standard insider reporting and equity plan procedures.

The Form 4 clearly identifies the reporting person’s role (SVP HR), the non-discretionary nature of the sale, and the inclusion of ESPP shares in beneficial ownership. The filing was executed via attorney-in-fact and contains explanatory notes clarifying compliance with equity-plan withholding mechanics. This meets typical governance and SEC disclosure expectations for employee equity transactions.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Green Paula

(Last) (First) (Middle)

C/O TWIST BIOSCIENCE CORPORATION

681 GATEWAY BLVD.

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Twist Bioscience Corp [ TWST ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	SVP of Human Resources

3. Date of Earliest Transaction (Month/Day/Year)
08/21/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	08/21/2025		S		619(1)	D	$25.964	125,729(2)	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

2. Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Remarks:

	/s/ Kendra Fox, as Attorney-in-Fact for Paula Green	08/25/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Paula Green (TWST) report on the Form 4?

The Form 4 reports a sale of 619 shares on 08/21/2025 at $25.964 per share, executed as a sell-to-cover to satisfy tax withholding on vested RSUs.

How many TWST shares does the reporting person own after the transaction?

Following the reported transaction the reporting person beneficially owned 125,729 shares, which includes shares from the Employee Stock Purchase Plan.

Was the sale by Paula Green discretionary or mandated?

The filing states the sale was a mandated sell-to-cover required by the issuer's equity incentive plan to satisfy tax withholding obligations, not a discretionary trade.

What price were the shares sold at in the Form 4?

The reported sale price was $25.964 per share.

Who signed the Form 4 and when?

The Form 4 was signed by an attorney-in-fact, /s/ Kendra Fox, on 08/25/2025.