TYRA issuer (Nasdaq: TYRA) lifts at-the-market stock program to $250M

Rhea-AI Filing Summary

The issuer of common stock trading under the symbol TYRA is updating its existing at-the-market equity program. An amendment to the sales agreement with TD Securities (USA) LLC (TD Cowen) permits additional issuances of common stock, par value $0.0001 per share, under an at-the-market offering.

The original sales agreement and related prospectus covered up to a maximum aggregate offering price of $150,000,000, all of which has been sold. After giving effect to this prospectus supplement and the amended sales agreement, the issuer may offer and sell up to an aggregate offering price of $250,000,000 of common stock. The common stock is listed on the Nasdaq Global Select Market, where the last reported sale price was $32.04 per share on August 3, 2026.

Key Figures

ATM capacity after supplement: $250,000,000 Previously sold under ATM: $150,000,000 Recent share price: $32.04 per share +2 more

5 metrics

ATM capacity after supplement $250,000,000 Maximum aggregate offering price of common stock under amended sales agreement

Previously sold under ATM $150,000,000 Aggregate amount of common stock sold pursuant to original sales agreement and ATM prospectus

Recent share price $32.04 per share Last reported sale price on Nasdaq Global Select Market on August 3, 2026

Par value per share $0.0001 Par value of the issuer’s common stock

Registration number 333-287086 SEC registration statement under which the ATM offering is made

Key Terms

at-the-market offering, prospectus supplement, Sales Agreement, Nasdaq Global Select Market, +1 more

5 terms

at-the-market offering financial

"the sale of shares of our common stock... through or to TD Cowen acting as our sales agent"

An at-the-market offering is a method companies use to sell new shares of stock directly into the open market over time, rather than all at once. This allows them to raise money gradually, similar to selling small pieces of a product instead of a large batch. For investors, it means the company can access funding more flexibly, but it may also increase the supply of shares and influence the stock’s price.

prospectus supplement regulatory

"This prospectus supplement is being filed to update, amend and supplement certain information"

A prospectus supplement is an additional document provided alongside a company's main offering details, offering updated or extra information about a specific financial product being sold. It helps investors understand the latest terms, risks, and details of the investment, similar to how an update or revision clarifies or expands on original instructions, ensuring they have current and complete information before making a decision.

Sales Agreement financial

"We previously entered into a sales agreement (the Sales Agreement), dated May 8, 2025"

A sales agreement is a written contract that sets out the terms for selling goods, services, or assets, specifying price, delivery, payment schedule and responsibilities of each side. For investors it matters because it creates a predictable stream of revenue or cash obligations, clarifies timing and risk, and can change a company’s value or forecasts much like a signed order turns a customer’s verbal intent into a firm commitment.

Nasdaq Global Select Market market

"Our common stock is listed on the Nasdaq Global Select Market under the symbol “TYRA”."

A Nasdaq Global Select Market listing is the highest tier of stocks on the Nasdaq exchange, reserved for companies that meet the strictest financial, reporting and governance standards. For investors, it acts like a premium quality label—signaling larger, more transparent and better-governed companies that tend to offer greater liquidity and lower perceived risk compared with lower-tier listings, making it easier to buy, sell and evaluate shares.

aggregate offering price financial

"covered the offering, issuance and sale by us of up to a maximum aggregate offering price of $150,000,000"

The aggregate offering price is the total dollar amount that will be raised if all the securities in an offering are sold at the stated offering price, before fees or expenses are taken out. Investors use it to gauge the size of the fundraising and its potential effects—such as how much cash the company will get and how much existing ownership might be reduced—similar to totaling every item’s price in a shopping cart to see the full bill.

Offering Details

ATM

Offering

Offering Type ATM

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Available on EDGAR 08/04/2026 - 04:59 PM Accepted by SEC EDGAR 08/04/2026 - 04:59 PM Learn about SEC filing dates

FAQ

What is TYRA changing in its at-the-market offering under this 424B5?

The issuer of TYRA common stock amended its sales agreement with TD Cowen so it can offer and sell up to an aggregate $250,000,000 of common stock through an at-the-market program, up from the original $150,000,000 capacity.

How much common stock has already been sold under the TYRA at-the-market program?

The issuer has sold an aggregate of $150,000,000 of its common stock under the original sales agreement and related prospectus, fully utilizing the prior maximum aggregate offering price that had been available for issuance.

What is the new maximum aggregate offering price for TYRA common stock?

After this prospectus supplement and the amended sales agreement, the issuer may offer and sell up to an aggregate offering price of $250,000,000 of its common stock under the at-the-market program, subject to registration limits.

Who is the sales agent for the TYRA at-the-market offering?

The issuer’s at-the-market offering is conducted under a sales agreement with TD Securities (USA) LLC (TD Cowen), which may act as sales agent or principal for the sale of the issuer’s common stock.

On which exchange is TYRA common stock listed and what was the recent price?

The issuer’s common stock is listed on the Nasdaq Global Select Market under the symbol TYRA. The last reported sale price was $32.04 per share on August 3, 2026.

Does the TYRA issuer warn of risks related to this common stock offering?

Yes. Investing in the issuer’s common stock involves a high degree of risk, and investors are directed to review risk factors in the at-the-market prospectus and the issuer’s most recent periodic reports filed with the SEC.

Filed Pursuant to Rule 424(b)(5)
Registration No. 333-287086

PROSPECTUS SUPPLEMENT

(To Prospectus dated May 16, 2025)

Up to $250,000,000

Common Stock

This prospectus supplement is being filed to update, amend and supplement certain information in the sales agreement prospectus filed with the Securities and Exchange Commission (the SEC) on May 8, 2025 and dated May 16, 2025 (the ATM Prospectus), filed as part of our registration statement on Form S-3 (File No. 333-287086). This prospectus supplement should be read in conjunction with the ATM Prospectus. This prospectus supplement is only intended to update, amend and supplement certain information in the ATM Prospectus to the extent set forth herein. Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the ATM Prospectus. This prospectus supplement is not complete without, and may only be delivered or utilized in connection with, the ATM Prospectus, and any future amendments or supplements thereto.

We previously entered into a sales agreement (the Sales Agreement), dated May 8, 2025, with TD Securities (USA) LLC (TD Cowen) relating to the sale of shares of our common stock, par value $0.0001 per share, through or to TD Cowen acting as our sales agent or principal. The ATM Prospectus and Sales Agreement covered the offering, issuance and sale by us of up to a maximum aggregate offering price of $150,000,000 of our common stock. As of the date of this prospectus supplement, we sold an aggregate of $150,000,000 of shares of our common stock pursuant to the Sales Agreement and the ATM Prospectus, utilizing the full amount then available for issuance. On August 4, 2026, we entered into an amendment to the Sales Agreement (as amended, the Amended Sales Agreement) to increase the maximum aggregate offering price for the shares of our common stock that we may offer and sell under the Amended Sales Agreement from $150,000,000 to such number as would not, among other limitations, exceed the number or dollar amount of shares registered on an effective registration statement pursuant to which the offering is made and for which we have filed prior to commencing the offering a prospectus or prospectus supplement. Pursuant to the Amended Sales Agreement and, after giving effect to this prospectus supplement, we may offer and sell up to an aggregate offering price of $250,000,000 of our common stock.

Our common stock is listed on the Nasdaq Global Select Market under the symbol “TYRA”. On August 3, 2026, the last reported sale price of our common stock on the Nasdaq Global Select Market was $32.04 per share.

Investing in our common stock involves a high degree of risk. Before making an investment decision, please read the information under the heading “Risk Factors” beginning on page 8 of the ATM Prospectus as well as those described in our most recent Annual Report on Form 10-K, any Quarterly Reports on Form 10-Q filed after such Annual Report on Form 10-K and in other information that we file from time to time with the SEC.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense.

TD Cowen

The date of this prospectus supplement is August 4, 2026.