VYNE Therapeutics Inc. (VYNE) reports 13.8% stake by Zhang Xiaofan

Rhea-AI Filing Summary

Zhang Xiaofan is reported as a significant shareholder of VYNE Therapeutics Inc., beneficially owning 4595118 shares of common stock, par value $0.0001 per share. This holding represents 13.8% of the class, with sole voting and sole dispositive power over all reported shares.

Key Figures

Shares beneficially owned: 4595118 shares Percent of class: 13.8% Sole voting power: 4595118 shares +3 more

6 metrics

Shares beneficially owned 4595118 shares Amount beneficially owned by Zhang Xiaofan in VYNE common stock

Percent of class 13.8% Percentage of VYNE common stock class owned by Zhang Xiaofan

Sole voting power 4595118 shares Shares for which Zhang Xiaofan has sole power to vote or direct the vote

Sole dispositive power 4595118 shares Shares for which Zhang Xiaofan has sole power to dispose or direct the disposition

Par value per share $0.0001 Par value of VYNE Therapeutics Inc. common stock

CUSIP 92941V308 CUSIP number for VYNE Therapeutics Inc. common stock

Key Terms

beneficially owned, Sole power to vote, dispositive power, CUSIP No.

4 terms

beneficially owned financial

"Item 4. | Ownership (a) | Amount beneficially owned: 4595118"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole power to vote financial

"(i) Sole power to vote or to direct the vote: 4595118"

dispositive power financial

"(iii) Sole power to dispose or to direct the disposition of: 4595118"

Dispositive power is the authority to decide the final outcome of an asset, legal claim, contract, or corporate action — in effect the power to dispose of or resolve something. For investors it matters because whoever holds that authority can determine who gets paid, who controls an asset or vote, and how risks and returns are allocated; think of it like holding the key that lets you lock in the winner or loser in a deal.

CUSIP No. financial

"(e) | CUSIP No.: 92941V308"

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Available on EDGAR 07/14/2026 - 10:07 AM Accepted by SEC EDGAR 07/14/2026 - 10:06 AM Learn about SEC filing dates

FAQ

Who is the large shareholder of VYNE (VYNE) disclosed in this Schedule 13G/A?

The filing identifies Zhang Xiaofan as a large shareholder of VYNE Therapeutics Inc. Zhang is the beneficial owner of VYNE common stock and reports personal details including a business address in Shanghai and Hong Kong citizenship.

How many VYNE (VYNE) shares does Zhang Xiaofan beneficially own?

Zhang Xiaofan beneficially owns 4595118 shares of VYNE Therapeutics Inc. common stock. This figure reflects all shares over which Zhang has either voting or dispositive power, as disclosed in the ownership section of the Schedule 13G/A amendment.

What percentage of VYNE (VYNE) common stock does Zhang Xiaofan hold?

Zhang Xiaofan holds 13.8% of VYNE Therapeutics Inc.’s outstanding common stock. This percentage of class is calculated and reported in the ownership section, indicating a significant minority position in the company’s equity.

What voting power does Zhang Xiaofan have over VYNE (VYNE) shares?

Zhang Xiaofan has sole power to vote or direct the vote for 4595118 shares of VYNE common stock. The filing reports no shared voting power, meaning all reported voting authority resides solely with Zhang for these shares.

What dispositive power does Zhang Xiaofan report over VYNE (VYNE) stock?

The amendment states that Zhang Xiaofan has sole power to dispose or direct the disposition of 4595118 shares of VYNE common stock. No shared dispositive power is reported, centralizing control over potential share sales or transfers with Zhang.

What is the class of securities and CUSIP reported for VYNE (VYNE)?

The securities covered are common stock of VYNE Therapeutics Inc., with a par value of $0.0001 per share. The filing lists the security’s CUSIP number as 92941V308, which uniquely identifies this class of VYNE equity in the market.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

VYNE Therapeutics Inc.

(Name of Issuer)

common stock, par value $0.0001

(Title of Class of Securities)

92941V308

(CUSIP Number)

07/13/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 92941V308

1

Names of Reporting Persons

Zhang Xiaofan

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power
6	Shared Voting Power
7	Sole Dispositive Power
8	Shared Dispositive Power

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12

Type of Reporting Person (See Instructions)

SCHEDULE 13G

Item 1.
(a)	Name of issuer: VYNE Therapeutics Inc.
(b)	Address of issuer's principal executive offices: 685 ROUTE 202/206 N., SUITE 301, 685 ROUTE 202/206 N., SUITE 301, BRIDGEWATER, NEW JERSEY, 08807.
Item 2.
(a)	Name of person filing: zhang xiaofan
(b)	Address or principal business office or, if none, residence: Rm1607, tower 3, central residence, 1038 Huashan Road, Shanghai
(c)	Citizenship: hong kong
(d)	Title of class of securities: common stock, par value $0.0001
(e)	CUSIP No.: 92941V308
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 4595118
(b)	Percent of class: 13.8%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 4595118
	(ii) Shared power to vote or to direct the vote:
	(iii) Sole power to dispose or to direct the disposition of: 4595118
	(iv) Shared power to dispose or to direct the disposition of:
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Zhang Xiaofan

Signature:	zhang xiaofan
Name/Title:	Mr
Date:	07/14/2026