Vanguard Amends 13G/A; Reports 0 Shares in Xeris

Xeris Biopharma Holdings Inc: The Vanguard Group filed Amendment No. 2 to a Schedule 13G/A reporting 0 shares beneficially owned and 0% of the class following an internal realignment.

Rhea-AI Filing Summary

Xeris Biopharma Holdings Inc: The Vanguard Group filed Amendment No. 2 to a Schedule 13G/A reporting 0 shares beneficially owned and 0% of the class following an internal realignment. The filing states certain Vanguard subsidiaries will report disaggregated holdings after the January 12, 2026 realignment.

The cover identifies the issuer address and CUSIP and is signed by Ashley Grim, Head of Global Fund Administration, dated 03/27/2026. The filing describes that Vanguard no longer is deemed to beneficially own securities held by the listed subsidiaries in reliance on SEC Release No. 34-39538.

Insights

Institutional Ownership Specialist

Amendment shows disaggregation of Vanguard holdings and reports zero direct beneficial ownership.

The filing documents an internal reorganization at The Vanguard Group and states that certain subsidiaries will report holdings separately after the January 12, 2026 realignment. The Schedule 13G/A cites SEC Release No. 34-39538 as the legal basis for disaggregation.

Practical effect: holdings formerly aggregated under Vanguard are now split across entity-level reports; subsequent filings by the subsidiaries will show specific positions. Cash‑flow treatment and the specific subsidiary holdings are not disclosed in this excerpt.

Securities Compliance Counsel

Filing formalizes reporting change under SEC guidance without asserting beneficial ownership.

The statement that Vanguard "no longer has, or is deemed to have, beneficial ownership" over securities held by certain subsidiaries relies on established SEC guidance (Release No. 34-39538). The amendment records 0 shares and 0% beneficial ownership for Vanguard itself.

Investors should expect separate 13G/A or 13D/13G entries from the named subsidiaries; timing and amounts for those subsidiary filings are not included in this excerpt.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does XERS Schedule 13G/A Amendment No. 2 say about Vanguard's holdings?

It reports that The Vanguard Group now shows 0 shares and 0% beneficial ownership. The filing explains an internal realignment on January 12, 2026 leading certain subsidiaries to report holdings separately under SEC Release No. 34-39538.

Why does The Vanguard Group report zero beneficial ownership for XERS?

Because Vanguard states it disaggregated holdings after an internal realignment on January 12, 2026. The filing cites SEC Release No. 34-39538 and says subsidiaries will report beneficial ownership separately.

Who signed the Schedule 13G/A amendment for Xeris (XERS)?

The amendment is signed by Ashley Grim, Head of Global Fund Administration. The signature block shows the filing date as 03/27/2026 and lists Vanguard's Malvern, Pennsylvania address.

Does this filing disclose the subsidiary holdings after disaggregation?

No; the amendment notes subsidiaries will report separately but does not list their holdings. Subsequent filings by those subsidiaries should show any specific share counts and percentages.

What legal basis does Vanguard cite for disaggregated reporting in the XERS filing?

The filing cites SEC Release No. 34-39538 (January 12, 1998) as the basis for reporting beneficial ownership separately by subsidiaries following the internal realignment.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 03/27/2026 - 02:12 PM EDT Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

Xeris Biopharma Holdings Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

98422E103

(CUSIP Number)

03/13/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 98422E103

1

Names of Reporting Persons

The Vanguard Group

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: On January 12, 2026, The Vanguard Group, Inc. went through an internal realignment. In accordance with SEC Release No. 34-39538 (January 12, 1998), certain subsidiaries or business divisions of subsidiaries of The Vanguard Group, Inc., that formerly had, or were deemed to have, beneficial ownership with The Vanguard Group, Inc., will report beneficial ownership separately (on a disaggregated basis) from The Vanguard Group, Inc. in reliance on such release. These subsidiaries and/or business divisions pursue the same investment strategies as previously pursued by The Vanguard Group, Inc. prior to the realignment. Further in accordance with SEC Release No. 34-39538 (January 12, 1998), The Vanguard Group, Inc. no longer has, or is deemed to have, beneficial ownership over securities beneficially owned by such subsidiaries and/or business divisions.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Xeris Biopharma Holdings Inc
(b)	Address of issuer's principal executive offices: 180 North LaSalle Street, Suite 1800, Chicago, IL, 60601
Item 2.
(a)	Name of person filing: The Vanguard Group
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd.,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.:
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 0
(b)	Percent of class: 0 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. The Vanguard Group, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

The Vanguard Group

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	03/27/2026