Xeris Biopharma: Vanguard reports 4.98% stake

Xeris Biopharma Holdings, Inc. (XERS) is identified as the issuer in an amended ownership report showing Vanguard Capital Management beneficially owned 9,086,791 common shares, or 4.98%, as of September 30, 2026.

Available on EDGAR 10/30/2026 - 12:36 PM EDT Accepted by SEC EDGAR 10/30/2026 - 12:35 PM EDT Learn about SEC filing dates

Rhea-AI Filing Summary

Xeris Biopharma Holdings, Inc. (XERS) is identified as the issuer in an amended ownership report showing Vanguard Capital Management beneficially owned 9,086,791 common shares, or 4.98%, as of September 30, 2026. Vanguard reported sole voting power over 1,376,435 shares and sole dispositive power over 9,086,791 shares; shared voting and dispositive power were both zero.

The reported ownership reflects securities held by Vanguard funds and certain clients, as well as the listed Vanguard affiliates and business divisions described in the report. Vanguard stated that no other person's interest in the reported securities exceeded 5%.

Key Figures

Beneficial ownership: 9,086,791 shares Percent of class: 4.98% Sole voting power: 1,376,435 shares +3 more

6 metrics

Beneficial ownership 9,086,791 shares As of September 30, 2026

Percent of class 4.98% As of September 30, 2026

Sole voting power 1,376,435 shares As of September 30, 2026

Sole dispositive power 9,086,791 shares As of September 30, 2026

Shared voting power 0 shares As of September 30, 2026

Shared dispositive power 0 shares As of September 30, 2026

Key Terms

beneficially owned, Sole power to vote or to direct the vote, Sole power to dispose or to direct the disposition

3 terms

beneficially owned financial

"Amount beneficially owned: 9086791"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole power to vote or to direct the vote financial

"Sole power to vote or to direct the vote: 1376435"

Sole power to dispose or to direct the disposition financial

"Sole power to dispose or to direct the disposition of: 9086791"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many XERS shares did Vanguard Capital Management report owning?

Vanguard Capital Management reported beneficial ownership of 9,086,791 Xeris Biopharma Holdings common shares, or 4.98%, as of September 30, 2026.

How much voting power did Vanguard report over XERS shares?

Vanguard reported sole power to vote or direct the vote of 1,376,435 shares as of September 30, 2026. It reported sole power to dispose of or direct the disposition of 9,086,791 shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

Xeris Biopharma Holdings Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

98422E103

(CUSIP Number)

09/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 98422E103

1

Names of Reporting Persons

Vanguard Capital Management

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 1,376,435.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 9,086,791.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

9,086,791.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

4.98 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Capital Management LLC and the following affiliates of Vanguard Capital Management LLC or business divisions of such affiliates: Vanguard Asset Management Limited, Vanguard Fiduciary Trust Company, Vanguard Global Advisers, LLC and Vanguard Investments Australia Ltd. This Schedule 13G includes securities held by Vanguard funds, or sleeves thereof, over which Vanguard Capital Management LLC exercises dispositive power, in addition to securities held by clients over which the affiliates or business divisions of such affiliates indicated above exercise dispositive and/or voting power. This Schedule 13G does not include securities, if any, beneficially owned by other subsidiaries or affiliates of Vanguard Capital Management LLC, or business divisions of such subsidiaries, whose ownership of securities is disaggregated from that of the reporting business unit in accordance with such release.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Xeris Biopharma Holdings Inc
(b)	Address of issuer's principal executive offices: 180 North LaSalle Street, Suite 1800, Chicago, IL, 60601
Item 2.
(a)	Name of person filing: Vanguard Capital Management
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 98422E103
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 9086791
(b)	Percent of class: 4.98 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 1376435
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 9086791
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Vanguard Capital Management, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Vanguard Capital Management

Signature:	My Trieu-Gatt
Name/Title:	Authorized Signatory, Head of Global Fund Administration
Date:	10/30/2026