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Zymeworks Inc. reports a Schedule 13G filing showing Perceptive-linked holders beneficially own 3,974,579 shares of Common Stock. The filing states this equals 5.4% of the class based on 73,749,607 shares outstanding as of February 26, 2026. Perceptive Life Sciences Master Fund directly holds the shares; Perceptive Advisors and Joseph Edelman are reported as investment manager and managing member, respectively.
Key Figures
Shares beneficially owned:3,974,579 sharesPercent of class:5.4%Shares outstanding:73,749,607 shares+1 more
4 metrics
Shares beneficially owned3,974,579 sharesDirect holding by Perceptive Life Sciences Master Fund
Percent of class5.4%Calculated by reporting persons based on outstanding shares
Shares outstanding73,749,607 sharesAs of <date>February 26, 2026</date> per company 10-K cited in filing
CUSIP98985Y108Identifies Zymeworks common stock in the filing
"The names of the persons filing this report (collectively, the "Reporting Persons")"
A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.
Beneficially ownfinancial
"The Master Fund directly holds 3,974,579 shares of Common Stock"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
Shared dispositive powerregulatory
"Shared Dispositive Power 3,974,579.00"
CUSIPtechnical
"Common Stock, $0.00001 par value per share 98985Y108"
A CUSIP is a nine-character alphanumeric code that uniquely identifies a U.S. or Canadian financial security—such as a stock, bond, or fund share—like a Social Security number for an investment. It matters to investors because brokers, exchanges and record-keepers use the CUSIP to match trades, track ownership, settle transactions and pull accurate records, reducing errors and ensuring money and securities go to the right place.
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
What stake does Perceptive Advisors hold in ZYME?
Perceptive Advisors is reported to beneficially own 3,974,579 shares (5.4%). The filing says Perceptive Advisors serves as investment manager and may be deemed to beneficially own the Master Fund's shares held directly.
How many Zymeworks shares were outstanding for the ownership calculation?
The ownership percentage is based on 73,749,607 shares outstanding as of February 26, 2026. That share count is cited from Zymeworks' Form 10-K referenced in the filing.
Who directly holds the 3,974,579 ZYME shares?
The filing states Perceptive Life Sciences Master Fund, Ltd. directly holds the 3,974,579 shares. Perceptive Advisors and Joseph Edelman are reported as manager and managing member linked to that holding.
Does the filing indicate sole voting or dispositive power over the shares?
Each Reporting Person is shown with 0 sole voting and dispositive power and 3,974,579 shared voting and dispositive power. The filing attributes shared authority rather than sole control.
When was the Schedule 13G signed and who signed it?
The joint filing agreement and cover pages are signed by Joseph Edelman as Managing Member, with signature dates of 04/15/2026. The cover page lists the CUSIP 98985Y108 and class as Common Stock.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
ZYMEWORKS INC.
(Name of Issuer)
Common Stock, $0.00001 par value per share
(Title of Class of Securities)
98985Y108
(CUSIP Number)
04/08/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
98985Y108
1
Names of Reporting Persons
Perceptive Advisors LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,974,579.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,974,579.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,974,579.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
5.4 %
12
Type of Reporting Person (See Instructions)
IA
SCHEDULE 13G
CUSIP Number(s):
98985Y108
1
Names of Reporting Persons
Joseph Edelman
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,974,579.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,974,579.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,974,579.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
5.4 %
12
Type of Reporting Person (See Instructions)
IN
SCHEDULE 13G
CUSIP Number(s):
98985Y108
1
Names of Reporting Persons
Perceptive Life Sciences Master Fund, Ltd.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
3,974,579.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
3,974,579.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
3,974,579.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
5.4 %
12
Type of Reporting Person (See Instructions)
CO
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
ZYMEWORKS INC.
(b)
Address of issuer's principal executive offices:
108 PATRIOT DRIVE, SUITE A, MIDDLETOWN, DE, 19709
Item 2.
(a)
Name of person filing:
The names of the persons filing this report (collectively, the "Reporting Persons") with respect to the Common Stock, $0.00001 par value per share (the "Common Stock") of ZYMEWORKS INC. (the "Issuer") are:
(i) Perceptive Advisors LLC ("Perceptive Advisors")
(ii) Joseph Edelman ("Mr. Edelman")
(iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund")
(b)
Address or principal business office or, if none, residence:
The address of the principal business office of each of the Reporting Persons is:
51 Astor Place, 10th Floor, New York, NY 10003
(c)
Citizenship:
Perceptive Advisors is a Delaware limited liability company.
Mr. Edelman is a United States citizen.
The Master Fund is a Cayman Islands corporation.
(d)
Title of class of securities:
Common Stock, $0.00001 par value per share
(e)
CUSIP Number(s):
98985Y108
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages are based on 73,749,607 shares of Common Stock outstanding as of February 26, 2026, as reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 2, 2026.
The Master Fund directly holds 3,974,579 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own the shares held by the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own the shares held by the Master Fund.
(b)
Percent of class:
Perceptive Advisors: 5.4%
Mr. Edelman: 5.4%
Master Fund: 5.4%
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Perceptive Advisors: 0
Mr. Edelman: 0
Master Fund: 0
(ii) Shared power to vote or to direct the vote:
Perceptive Advisors: 3,974,579
Mr. Edelman: 3,974,579
Master Fund: 3,974,579
(iii) Sole power to dispose or to direct the disposition of:
Perceptive Advisors: 0
Mr. Edelman: 0
Master Fund: 0
(iv) Shared power to dispose or to direct the disposition of:
Perceptive Advisors: 3,974,579
Mr. Edelman: 3,974,579
Master Fund: 3,974,579
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
Not Applicable
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
