What is Nautilus Biotechnology Inc's earnings per share (EPS)?

Nautilus Biotechnology Inc (NAUT) reported diluted earnings per share of $-0.47 for fiscal year 2025. This represents a 16.1% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

Nautilus Biotechnology Inc Financials

NAUT

Source SEC Filings (10-K/10-Q) Updated Mar 31, 2026 Currency USD FYE December

This page shows Nautilus Biotechnology Inc (NAUT) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 6 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI NAUT FY2025 2026-04-28

Legacy cash reserves, not revenue, are funding Nautilus's operating model as annual burn remains near -$52.0M.

By FY2025, free cash flow was still -$52.0M even as net loss improved to -$59.0M, so the reported improvement came mostly from lower spending rather than from a business that is starting to self-fund. The subtler cushion sits outside cash: with only $12.4M on hand but $106.0M of current assets and positive investing cash flow, liquidity is being supported by drawing down previously invested assets rather than by operations or new financing.

FY2025's smaller loss came with R&D retrenchment and lower SG&A, which suggests management is stretching runway by reducing the research and overhead load rather than benefiting from commercial scale. Because operating cash flow at -$50.7M sits close to net loss, these losses are mostly cash costs, not accounting noise.

The balance sheet is lightly encumbered: total liabilities are only $34.1M against equity of $157.0M, so the constraint is runway, not debt service. Since FY2022, share count barely moved while financing inflows were minimal, indicating recent burn has been absorbed mostly by using assets already on the balance sheet rather than by repeated outside capital raises.

Financial Health Signals

Financial Profile 33/100

Based on FY2025 annual data, averaged across the last 3 years for performance metrics (most-recent year weighted highest). How this score is calculated →

Health score ≠ stock price. This rates the quality of Nautilus Biotechnology Inc's business: profitability, growth, balance sheet strength. It doesn't tell you whether the stock is a good buy at today's price. Not financial advice. Use it alongside valuation analysis and your own research.

Leverage

Nautilus Biotechnology Inc carries a low D/E ratio of 0.22, meaning only $0.22 of long-term debt for every $1 of shareholders' equity. This conservative leverage earns a score of 98/100, indicating a strong balance sheet with room for future borrowing.

Liquidity

100

With a current ratio of 13.33, Nautilus Biotechnology Inc holds $13.33 in current assets for every $1 of short-term obligations. This comfortable liquidity earns a score of 100/100.

Returns

Nautilus Biotechnology Inc generates a -37.6% ROE, indicating limited profit relative to shareholders' investment. This results in a returns score of 0/100. This is down from -33.9% the prior year.

Piotroski F-Score Weak

1/9

Nautilus Biotechnology Inc passes 1 of 9 financial strength tests. 1 of 4 profitability signals pass, no leverage/liquidity signals pass (rising debt, declining liquidity, or share dilution).

Earnings Quality Low Quality

0.86x

For every $1 of reported earnings, Nautilus Biotechnology Inc generates $0.86 in operating cash flow (-$50.7M OCF vs -$59.0M net income). This low ratio suggests earnings are primarily driven by accounting accruals rather than cash generation, which may not be sustainable.

Key Financial Metrics

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Earnings & Revenue

Revenue

N/A

EBITDA

N/A

Net Income

-$59.0M

YoY+16.6%

Nautilus Biotechnology Inc reported -$59.0M in net income in fiscal year 2025. This represents an increase of 16.6% from the prior year.

EPS (Diluted)

$-0.47

YoY+16.1%

Nautilus Biotechnology Inc earned $-0.47 per diluted share (EPS) in fiscal year 2025. This represents an increase of 16.1% from the prior year.

Cash & Balance Sheet

Free Cash Flow

-$52.0M

YoY+15.2%

Nautilus Biotechnology Inc generated -$52.0M in free cash flow in fiscal year 2025, representing cash available after capex. This represents an increase of 15.2% from the prior year.

Cash & Debt

$12.4M

YoY-55.2%

5Y CAGR-19.5%

Nautilus Biotechnology Inc held $12.4M in cash against $0 in long-term debt as of fiscal year 2025.

Dividends Per Share

N/A

Shares Outstanding

126M

YoY+0.3%

Nautilus Biotechnology Inc had 126M shares outstanding in fiscal year 2025. This represents an increase of 0.3% from the prior year.

Margins & Returns

Gross Margin

N/A

Operating Margin

N/A

Net Margin

N/A

Return on Equity

-37.6%

YoY-3.7pp

Nautilus Biotechnology Inc's ROE was -37.6% in fiscal year 2025, measuring profit generated per dollar of shareholder equity. This is down 3.7 percentage points from the prior year.

Capital Allocation

R&D Spending

$41.1M

YoY-18.6%

5Y CAGR+27.0%

Nautilus Biotechnology Inc invested $41.1M in research and development in fiscal year 2025. This represents a decrease of 18.6% from the prior year.

Share Buybacks

N/A

Capital Expenditures

$1.3M

YoY-39.8%

5Y CAGR+6.8%

Nautilus Biotechnology Inc invested $1.3M in capex in fiscal year 2025, funding long-term assets and infrastructure. This represents a decrease of 39.8% from the prior year.

NAUT Income Statement

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Revenue	N/A	N/A	N/A	N/A	N/A	N/A
Cost of Revenue	N/A	N/A	N/A	N/A	N/A	N/A
Gross Profit	N/A	N/A	N/A	N/A	N/A	N/A
R&D Expenses	$41.1M-18.6%	$50.5M+6.8%	$47.3M+25.4%	$37.7M+28.3%	$29.4M+136.1%	$12.4M
SG&A Expenses	$25.7M-17.0%	$31.0M+7.3%	$28.9M+11.4%	$25.9M+22.7%	$21.1M+538.5%	$3.3M
Operating Income	N/A	N/A	N/A	N/A	N/A	N/A
Interest Expense	N/A	N/A	N/A	N/A	N/A	N/A
Income Tax	$0	$0	$0	$0	$0	$0
Net Income	-$59.0M+16.6%	-$70.8M-11.2%	-$63.7M-9.9%	-$57.9M-15.1%	-$50.3M-222.1%	-$15.6M
EPS (Diluted)	$-0.47+16.1%	$-0.56-9.8%	$-0.51-10.9%	$-0.46+23.3%	$-0.60	$-0.54

Metric	Q1'26	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24
Revenue	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cost of Revenue	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Gross Profit	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
R&D Expenses	$9.7M	N/A	$9.6M-7.6%	$10.4M-9.9%	$11.5M	N/A	$12.3M-1.2%	$12.4M
SG&A Expenses	$6.4M	N/A	$5.9M-12.5%	$6.7M-8.3%	$7.3M	N/A	$6.8M-18.4%	$8.4M
Operating Income	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Interest Expense	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Income Tax	$0	N/A	$0	$0	$0	N/A	$0	$0
Net Income	-$14.7M	N/A	-$13.6M+9.7%	-$15.0M+9.5%	-$16.6M	N/A	-$16.4M+8.7%	-$18.0M
EPS (Diluted)	$-0.12	N/A	$-0.11+8.3%	$-0.12+7.7%	$-0.13	N/A	$-0.13+7.1%	$-0.14

NAUT Balance Sheet

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Total Assets	$191.1M-21.3%	$242.7M-20.6%	$305.6M-12.7%	$350.1M-12.1%	$398.4M+368.7%	$85.0M
Current Assets	$106.0M-20.2%	$132.8M-24.9%	$176.8M-5.5%	$187.2M-46.4%	$349.2M+349.7%	$77.7M
Cash & Equivalents	$12.4M-55.2%	$27.6M+42.5%	$19.4M-83.1%	$114.5M-38.3%	$185.6M+407.1%	$36.6M
Inventory	N/A	N/A	N/A	N/A	N/A	N/A
Accounts Receivable	N/A	N/A	N/A	N/A	N/A	N/A
Goodwill	N/A	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$34.1M+0.4%	$34.0M-15.4%	$40.2M+14.5%	$35.1M+0.7%	$34.9M-69.6%	$114.7M
Current Liabilities	$8.0M+4.2%	$7.6M-16.3%	$9.1M+34.3%	$6.8M+16.8%	$5.8M+92.6%	$3.0M
Long-Term Debt	N/A	N/A	N/A	N/A	N/A	N/A
Total Equity	$157.0M-24.8%	$208.7M-21.3%	$265.4M-15.7%	$314.9M-13.4%	$363.6M+1323.3%	-$29.7M
Retained Earnings	-$332.0M-21.6%	-$273.0M-35.0%	-$202.2M-46.0%	-$138.6M-71.8%	-$80.6M-165.9%	-$30.3M

Metric	Q1'26	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24
Total Assets	$177.8M-7.0%	$191.1M-4.9%	$200.9M-5.8%	$213.2M-6.4%	$227.7M-6.2%	$242.7M-6.5%	$259.7M-4.8%	$272.7M
Current Assets	$98.8M-6.7%	$106.0M-21.1%	$134.3M-10.9%	$150.7M+6.4%	$141.6M+6.6%	$132.8M-7.9%	$144.2M-15.6%	$170.9M
Cash & Equivalents	$14.6M+18.1%	$12.4M-48.1%	$23.9M-30.7%	$34.5M+3.7%	$33.2M+20.2%	$27.6M+527.0%	$4.4M-82.3%	$24.9M
Inventory	$300K	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Accounts Receivable	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Goodwill	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$33.4M-2.3%	$34.1M+7.4%	$31.8M-1.0%	$32.1M-3.5%	$33.3M-2.2%	$34.0M-6.2%	$36.3M-3.2%	$37.5M
Current Liabilities	$8.3M+4.9%	$8.0M-11.5%	$9.0M+10.4%	$8.1M-0.2%	$8.2M+6.9%	$7.6M-11.9%	$8.7M-0.2%	$8.7M
Long-Term Debt	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Total Equity	$144.4M-8.0%	$157.0M-7.2%	$169.1M-6.6%	$181.1M-6.9%	$194.4M-6.8%	$208.7M-6.6%	$223.4M-5.0%	$235.3M
Retained Earnings	-$346.7M-4.4%	-$332.0M-4.3%	-$318.2M-4.5%	-$304.7M-5.2%	-$289.6M-6.1%	-$273.0M-6.9%	-$255.4M-6.9%	-$239.0M

NAUT Cash Flow Statement

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Operating Cash Flow	-$50.7M+14.3%	-$59.1M-14.4%	-$51.7M-12.9%	-$45.8M-16.7%	-$39.2M-180.4%	-$14.0M
Capital Expenditures	$1.3M-39.8%	$2.1M-13.1%	$2.4M+5.1%	$2.3M+2.4%	$2.3M+146.4%	$921K
Free Cash Flow	-$52.0M+15.2%	-$61.3M-13.1%	-$54.2M-12.5%	-$48.1M-15.9%	-$41.5M-178.3%	-$14.9M
Investing Cash Flow	$35.2M-46.8%	$66.3M+251.5%	-$43.7M-69.9%	-$25.7M+81.5%	-$139.0M-449.7%	-$25.3M
Financing Cash Flow	$214K-81.3%	$1.1M+210.9%	$368K-34.5%	$562K-99.8%	$327.4M+331.4%	$75.9M
Dividends Paid	N/A	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A	N/A

Metric	Q1'26	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24
Operating Cash Flow	-$13.1M-5.9%	-$12.4M-12.2%	-$11.0M+17.3%	-$13.3M+4.2%	-$13.9M+2.6%	-$14.3M-9.1%	-$13.1M+15.2%	-$15.5M
Capital Expenditures	$510K+109.0%	$244K-41.6%	$418K+5.6%	$396K+80.8%	$219K-13.8%	$254K-64.2%	$709K+38.5%	$512K
Free Cash Flow	-$13.6M-7.9%	-$12.6M-10.2%	-$11.5M+16.7%	-$13.7M+2.9%	-$14.2M+2.8%	-$14.6M-5.4%	-$13.8M+13.4%	-$16.0M
Investing Cash Flow	$14.2M+1708.5%	$787K+74.1%	$452K-96.9%	$14.5M-25.8%	$19.5M-47.4%	$37.1M+594.5%	-$7.5M-152.5%	$14.3M
Financing Cash Flow	$1.1M+994.1%	$101K	$0-100.0%	$95K+427.8%	$18K-95.9%	$440K+214.3%	$140K-56.1%	$319K
Dividends Paid	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

NAUT Financial Ratios

Metric	FY25	FY24	FY23	FY22	FY21	FY20
Gross Margin	N/A	N/A	N/A	N/A	N/A	N/A
Operating Margin	N/A	N/A	N/A	N/A	N/A	N/A
Net Margin	N/A	N/A	N/A	N/A	N/A	N/A
Return on Equity	-37.6%-3.7pp	-33.9%-9.9pp	-24.0%-5.6pp	-18.4%-4.6pp	-13.8%	N/A
Return on Assets	-30.9%-1.7pp	-29.2%-8.3pp	-20.8%-4.3pp	-16.6%-3.9pp	-12.6%+5.7pp	-18.4%
Current Ratio	13.33-4.1	17.40-2.0	19.39-8.2	27.57-32.5	60.09+34.4	25.73
Debt-to-Equity	0.22+0.1	0.16+0.0	0.15+0.0	0.11+0.0	0.10+4.0	-3.86
FCF Margin	N/A	N/A	N/A	N/A	N/A	N/A

Metric	Q1'26	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24
Gross Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Operating Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Net Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Return on Equity	-10.2%	N/A	-8.0%+0.3pp	-8.3%+0.2pp	-8.5%	N/A	-7.4%+0.3pp	-7.6%
Return on Assets	-8.3%	N/A	-6.8%+0.3pp	-7.0%+0.3pp	-7.3%	N/A	-6.3%+0.3pp	-6.6%
Current Ratio	11.85-1.5	13.33-1.6	14.95-3.6	18.52+1.2	17.36-0.0	17.40+0.8	16.65-3.0	19.69
Debt-to-Equity	0.23+0.0	0.22+0.0	0.19+0.0	0.180.0	0.170.0	0.160.0	0.160.0	0.16
FCF Margin	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

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Frequently Asked Questions

Is Nautilus Biotechnology Inc profitable?

No, Nautilus Biotechnology Inc (NAUT) reported a net income of -$59.0M in fiscal year 2025.

What is Nautilus Biotechnology Inc's return on equity (ROE)?

Nautilus Biotechnology Inc (NAUT) has a return on equity of -37.6% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

What is Nautilus Biotechnology Inc's free cash flow?

Nautilus Biotechnology Inc (NAUT) generated -$52.0M in free cash flow during fiscal year 2025. This represents a 15.2% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

What is Nautilus Biotechnology Inc's operating cash flow?

Nautilus Biotechnology Inc (NAUT) generated -$50.7M in operating cash flow during fiscal year 2025, representing cash generated from core business activities.

What are Nautilus Biotechnology Inc's total assets?

Nautilus Biotechnology Inc (NAUT) had $191.1M in total assets as of fiscal year 2025, including both current and long-term assets.

What are Nautilus Biotechnology Inc's capital expenditures?

Nautilus Biotechnology Inc (NAUT) invested $1.3M in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

How much does Nautilus Biotechnology Inc spend on research and development?

Nautilus Biotechnology Inc (NAUT) invested $41.1M in research and development during fiscal year 2025.

How many shares does Nautilus Biotechnology Inc have outstanding?

Nautilus Biotechnology Inc (NAUT) had 126M shares outstanding as of fiscal year 2025.

What is Nautilus Biotechnology Inc's current ratio?

Nautilus Biotechnology Inc (NAUT) had a current ratio of 13.33 as of fiscal year 2025, which is generally considered healthy.

What is Nautilus Biotechnology Inc's debt-to-equity ratio?

Nautilus Biotechnology Inc (NAUT) had a debt-to-equity ratio of 0.22 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

What is Nautilus Biotechnology Inc's return on assets (ROA)?

Nautilus Biotechnology Inc (NAUT) had a return on assets of -30.9% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

What is Nautilus Biotechnology Inc's cash runway?

Based on fiscal year 2025 data, Nautilus Biotechnology Inc (NAUT) had $12.4M in cash against an annual operating cash burn of $50.7M. This gives an estimated cash runway of approximately 3 months at the current burn rate. Cash runway measures how long a company can continue operating before running out of cash, assuming no additional funding.

What is Nautilus Biotechnology Inc's Piotroski F-Score?

Nautilus Biotechnology Inc (NAUT) has a Piotroski F-Score of 1 out of 9, indicating weak financial health. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Are Nautilus Biotechnology Inc's earnings high quality?

Nautilus Biotechnology Inc (NAUT) has an earnings quality ratio of 0.86x, considered low quality (accrual-driven). This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

How financially healthy is Nautilus Biotechnology Inc?

Nautilus Biotechnology Inc (NAUT) scores 33 out of 100 on our Financial Profile, indicating weak overall financial health. This composite score evaluates six dimensions: profitability (operating margin), revenue growth, leverage (debt-to-equity), liquidity (current ratio), cash flow quality (free cash flow margin), and shareholder returns (return on equity). Each dimension is normalized against standard financial benchmarks. Learn more in our complete guide to financial health indicators.