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OnKure Therapeutics, Inc. (OKUR) Financials

OKUR
Trailing 12 months to June 30, 2026
Net Income -$58.7M +2.7% YoY
EPS (Diluted) -$4.40 FY2025 annual
Free Cash Flow -$47.9M +22.0% YoY
Operating Cash Flow -$47.8M +21.9% YoY
Market Cap $97.6M as of Oct 10, 2026
Price / Sales n/m no revenue reported
Price / Earnings n/m net loss, so no earnings multiple, trailing 12 months to June 30, 2026
Price / Book 0.6x on $172.1M equity, Q2 FY2026

A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 10, 2026; every other figure is from the SEC filings on this page. Not financial advice.

Source SEC Filings (10-K/10-Q) Latest period Q2 FY2026, ended Jun 30, 2026 Reported Currency USD FYE December

Newest figures come from the 10-Q for Q2 FY2026, filed Aug 4, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the OKUR SEC filings page.

This page shows OnKure Therapeutics, Inc. (OKUR) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 6 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI OKUR FY2025

OnKure operates as a development-stage biotech, with R&D-driven losses funded mainly by prior financing rather than operating revenue.

In FY2025, operating cash outflow of $51.8M nearly matched free cash flow of -$51.9M, while capital expenditures were only $46K; cash use is overwhelmingly operational, not driven by building a heavy physical asset base. The supplied liquidity measure equaled 13.7 months of reported annual operating outflow, linking the balance of cash and investments to the scale of that spending.

R&D increased from $43.8M in FY2024 to $48.3M in FY2025 as the operating loss widened from $54.4M to $63.0M. With no usable revenue figure in either period, the statements describe a company still converting research spending into losses rather than sales.

FY2024 financing of $116.1M helped lift assets to $114.9M, but FY2025 financing was only $163K and assets fell to $62.1M. The balance sheet therefore depends on periodic capital raising; low reported liabilities of $5.9M indicate the pressure is funding availability rather than debt-heavy financing.

[ NOT FINANCIAL ADVICE ]

Financial Health Signals

Financial health score not available

OnKure Therapeutics, Inc. does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.

Piotroski F-Score Partial
1/5

OnKure Therapeutics, Inc. passes 1 of 5 computable financial strength tests (4 of the nine could not be computed from available data). 1 of 4 profitability signals pass, no leverage/liquidity signals pass (rising debt, declining liquidity, or share dilution).

Earnings Quality No Cash Backing
N/A

OnKure Therapeutics, Inc. reported a net loss of $59.5M while operations used $51.8M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Interest Coverage At Risk
N/A

OnKure Therapeutics, Inc. reported an operating loss of $63.0M against $3.4M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations.

Key Financial Metrics

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Earnings & Revenue

EBITDA
-$16.8M
YoY-3.7%
QoQ-8.4%

OnKure Therapeutics, Inc.'s EBITDA was -$16.8M in Q2 2026, measuring earnings before interest, taxes, depreciation, and amortization. This represents a decrease of 3.7% from the same quarter a year earlier. Against the prior quarter it is down 8.4%.

Net Income
-$15.3M
YoY+0.3%
QoQ-1.2%

OnKure Therapeutics, Inc. reported -$15.3M in net income in Q2 2026. This represents an increase of 0.3% from the same quarter a year earlier. Against the prior quarter it is down 1.2%.

EPS (Diluted)
-$0.31

OnKure Therapeutics, Inc. earned -$0.31 per diluted share (EPS) in Q2 2026.

Revenue

Not reported for Q2 2026.

Cash & Balance Sheet

Free Cash Flow
-$10.4M
YoY+22.1%
QoQ+20.0%

OnKure Therapeutics, Inc. recorded an outflow of $10.4M in free cash flow in Q2 2026, representing a cash shortfall after capex. This represents an increase of 22.1% from the same quarter a year earlier. Against the prior quarter it is up 20.0%.

Cash & Debt
$166.5M
YoY+99.7%
QoQ-13.3%
5Y CAGR+3.5%

OnKure Therapeutics, Inc. held $166.5M in cash as of Q2 2026; long-term debt is not reported for that period.

Shares Outstanding
40M

OnKure Therapeutics, Inc. had 40M shares outstanding in Q2 2026.

Dividends Per Share

Not reported for Q2 2026.

Margins & Returns

Return on Equity
-8.9%
YoY+10.8pp
QoQ-0.7pp

OnKure Therapeutics, Inc.'s ROE was -8.9% in Q2 2026, measuring profit generated per dollar of shareholder equity. This is up 10.8 percentage points from the same quarter a year earlier. Against the prior quarter it is down 0.7 percentage points.

Gross Margin

Not reported for Q2 2026.

Operating Margin

Not reported for Q2 2026.

Net Margin

Not reported for Q2 2026.

Capital Allocation

R&D Spending
$12.6M
YoY0.0%
QoQ+7.7%

OnKure Therapeutics, Inc. invested $12.6M in research and development in Q2 2026. That is unchanged from the same quarter a year earlier. Against the prior quarter it is up 7.7%.

Capital Expenditures
$3K
YoY-76.9%
QoQ-40.0%
5Y CAGR-12.9%

OnKure Therapeutics, Inc. invested $3K in capex in Q2 2026, funding long-term assets and infrastructure. This represents a decrease of 76.9% from the same quarter a year earlier. Against the prior quarter it is down 40.0%.

Share Buybacks

Not reported for Q2 2026.

OKUR Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

OKUR quarterly income statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-QQ3'2410-Q
R&D Expenses$12.6M0.0%$11.7M-10.0%N/A$11.9M+17.8%$12.6M+17.3%$13.0M+51.9%N/A$10.1M-25.7%
SG&A Expenses$4.3M+15.5%$3.9M-2.0%N/A$3.6M+156.9%$3.7M+3.3%$4.0M+215.3%N/A$1.4M-80.8%
Operating Income-$16.9M-3.5%-$15.6M+8.1%N/A-$15.5M-34.7%-$16.3M-13.8%-$17.0M-72.9%N/A-$11.5M+44.9%
EBITDA-$16.8M-3.7%-$15.5M+8.1%N/A-$15.4M-35.1%-$16.2M-13.9%-$16.9M-73.7%N/A-$11.4M+45.3%
Interest Expense$1.6M+66.3%$458K-57.4%N/A$802K+1922.7%$934K+357.8%$1.1MN/A-$44K
Net Income-$15.3M+0.3%-$15.2M+4.8%-$13.5M+22.6%-$14.7M-27.2%-$15.4M-8.8%-$15.9M-67.0%-$17.4M-$11.6M+39.8%
EPS (Basic)-$0.31+72.8%-$1.11+6.7%-$0.99+90.1%-$1.09+97.0%-$1.14+97.5%-$1.19+96.1%-$10.05+90.5%-$36.55-543.5%
EPS (Diluted)-$0.31-$1.11+6.7%-$0.99-$1.09-$1.14-$1.19-$10.05+90.5%-$36.55
Diluted Shares (Avg)50M14M+1.9%N/A14M14M13MN/A316,142

Not reported in any period shown, so not listed: Revenue, Cost of Revenue, Gross Profit, Income Tax.

OKUR Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

OKUR quarterly balance sheet
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-QQ3'2410-Q
Total Assets$179.4M+108.4%$198.7M+98.9%$62.1M-45.9%$72.8M-6.2%$86.1M+9.3%$99.9M+18.0%$114.9M+221.6%$77.6M-40.5%
Current Assets$177.7M+110.1%$197.5M+101.2%$60.8M-46.2%$71.5M-7.1%$84.6M+8.4%$98.2M+17.0%$113.0M+234.7%$77.0M-40.2%
Cash & Equivalents$166.5M+99.7%$192.1M+98.7%$59.0M-46.7%$70.3M+15.9%$83.4M+131.8%$96.7M+374.4%$110.8M+270.7%$60.7M+417.1%
Short-Term Investments$9.9M$0$0$0-100.0%$0-100.0%$0-100.0%$0$16.0M-86.0%
Long-Term Investments$0$0$0$0$0$0$0$0
Total Liabilities$7.2M-8.3%$14.3M+55.3%$5.9M-46.4%$6.4M-97.0%$7.9M-96.1%$9.2M-95.3%$11.1M-91.9%$212.7M+1277.2%
Current Liabilities$6.6M-12.6%$14.3M+63.1%$5.9M-43.8%$6.2M+92.3%$7.6M+463.6%$8.8M+212.2%$10.5M+44.5%$3.2M-76.1%
Non-Current Liabilities$602K+96.1%$12K-97.3%$12K-97.8%$160K-99.9%$307K-99.8%$449K-99.8%$549K-99.6%$209.4M+11034.9%
Total Equity$172.1M+120.2%$184.4M+103.4%$56.2M-45.9%$66.4M+149.2%$78.2M+163.3%$90.6M+181.5%$103.8M+202.0%-$135.1M-217.5%
Retained Earnings-$244.7M-31.6%-$229.4M-34.4%-$214.2M-38.5%-$200.7M+14.9%-$186.0M+19.9%-$170.6M+24.8%-$154.7M-51.6%-$236.0M-23.8%

Not reported in any period shown, so not listed: Inventory, Accounts Receivable, Goodwill, Long-Term Debt.

OKUR Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

OKUR quarterly cash flow statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-QQ3'2410-Q
Operating Cash Flow-$10.4M+22.0%-$12.9M+7.6%-$11.5M+50.7%-$13.0M-22.3%-$13.3M-105.1%-$14.0M-31.8%-$23.4M-348.9%-$10.7M+43.2%
Depreciation & Amortization$87K-25.6%$104K-11.9%$104K-10.3%$108K-5.3%$117K+1.7%$118K+3.5%$116K-60.1%$114K+165.1%
Stock-Based Compensation$3.0M+4.8%$2.8M+1.3%N/A$3.0M+3745.5%$2.9M+60.4%$2.7M+2465.4%N/A$77K-94.6%
Capital Expenditures$3K-76.9%$5K-72.2%$9K-40.0%$6K-66.7%$13K+30.0%$18K+100.0%$15K-70.0%$18K-5.3%
Free Cash Flow-$10.4M+22.1%-$12.9M+7.7%-$11.5M+50.7%-$13.0M-22.1%-$13.3M-105.0%-$14.0M-31.8%-$23.4M-350.4%-$10.7M+43.2%
Investing Cash Flow-$9.9M-75823.1%-$5K+72.2%-$9K-100.1%-$6K+66.7%-$13K-30.0%-$18K-100.0%$15.9M-45.2%-$18K-100.1%
Financing Cash Flow-$5.4M$146.0M+189709.1%$240K-99.8%$0-100.0%$0-100.0%-$77K-870.0%$110.2M+1028.9%$5K-97.1%

Not reported in any period shown, so not listed: Dividends Paid, Share Buybacks.

OKUR Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

OKUR quarterly financial ratios
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-QQ3'2410-Q
Return on Equity-8.9%+10.8pp-8.2%+9.3pp-24.0%-7.2pp-22.1%-19.7%-17.6%-16.8%N/A
Return on Assets-8.6%+9.3pp-7.6%+8.3pp-21.7%-6.6pp-20.2%-5.3pp-17.9%+0.1pp-15.9%-4.7pp-15.2%-14.9%-0.2pp
Current Ratio26.75+15.6x13.78+2.6x10.28-0.5x11.45-12.3x11.13-46.7x11.18-18.6x10.73+6.1x23.71+14.2x
Debt-to-Equity0.04-0.1x0.080.0x0.110.0x0.100.100.100.11N/A

Not reported in any period shown, so not listed: Gross Margin, Operating Margin, Net Margin, Asset Turnover, FCF Margin.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
OnKure Therapeutics, Inc. OKUR FY2025 N/A -$59.5M N/A $97.6M —
AN2 Therapeutics, Inc. ANTX FY2025 N/A -$35.2M N/A $166.0M —
Iterum Therapeutics plc ITRM FY2025 N/A -$24.8M N/A $1.6M —
Kezar Life Sciences, Inc. KZR FY2025 $0 -$56.0M N/A $53.9M —
Estrella Immunopharma, Inc. ESLA FY2025 N/A -$13.1M N/A $17.8M —
Mersana Therapeutics, Inc. MRSN FY2024 $40.5M -$69.2M N/A $145.4M 54/100

Frequently Asked Questions

Is OnKure Therapeutics, Inc. profitable?

No, OnKure Therapeutics, Inc. (OKUR) reported a net income of -$59.5M in fiscal year 2025.

What is OnKure Therapeutics, Inc.'s earnings per share (EPS)?

OnKure Therapeutics, Inc. (OKUR) reported diluted earnings per share of -$4.40 for fiscal year 2025. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

What is OnKure Therapeutics, Inc.'s EBITDA?

OnKure Therapeutics, Inc. (OKUR) had EBITDA of -$62.5M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

OnKure Therapeutics, Inc. (OKUR) has a return on equity of -105.9% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

OnKure Therapeutics, Inc. (OKUR) recorded an outflow of $51.9M in free cash flow during fiscal year 2025. This represents a -1.4% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

OnKure Therapeutics, Inc. (OKUR) recorded an outflow of $51.8M in operating cash flow during fiscal year 2025, representing cash used by core business activities.

OnKure Therapeutics, Inc. (OKUR) had $62.1M in total assets as of fiscal year 2025, including both current and long-term assets.

OnKure Therapeutics, Inc. (OKUR) invested $46K in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

OnKure Therapeutics, Inc. (OKUR) invested $48.3M in research and development during fiscal year 2025.

OnKure Therapeutics, Inc. (OKUR) had 14M shares outstanding as of fiscal year 2025.

OnKure Therapeutics, Inc. (OKUR) had a current ratio of 10.28 as of fiscal year 2025, which is generally considered healthy.

OnKure Therapeutics, Inc. (OKUR) had a debt-to-equity ratio of 0.11 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

OnKure Therapeutics, Inc. (OKUR) had a return on assets of -95.8% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

OnKure Therapeutics, Inc. (OKUR) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (trailing 12 months to June 30, 2026). The market capitalization is $97.6M as of Oct 10, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

OnKure Therapeutics, Inc. (OKUR) has no price-to-sales ratio at the moment: no revenue reported. The market capitalization is $97.6M as of Oct 10, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

At the end of fiscal year 2025, OnKure Therapeutics, Inc. (OKUR) held $59.0M in cash, cash equivalents and investments, and reported an operating cash outflow of $51.8M over that year. Dividing the one by the other, the reported balance equals about 14 months of the outflow reported that year. This is arithmetic over figures already filed, not a projection: it assumes nothing about future spending, financing or operations.

OnKure Therapeutics, Inc. (OKUR) has a Piotroski F-Score of 1 out of 5 computable signals; 4 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

OnKure Therapeutics, Inc. (OKUR) reported a net loss of $59.5M while operations used $51.8M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

OnKure Therapeutics, Inc. (OKUR) reported an operating loss of $63.0M against $3.4M in interest expense. There is no operating profit to cover interest, so interest must be met from cash reserves or from financing rather than from operations. This ratio divides operating income by interest expense. Ratios above 5x indicate strong debt-servicing ability, while ratios below 2x suggest the company may face difficulty meeting interest payments if earnings decline. Learn more in our complete guide to financial health indicators.

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