Absci Reports Business Updates and Second Quarter 2025 Financial and Operating Results

Rhea-AI Summary

Absci Corporation (Nasdaq: ABSI) reported Q2 2025 financial results and business updates, highlighting significant developments in their clinical pipeline and financial position. The company successfully raised $64 million in gross proceeds in July 2025, extending their operational runway into H1 2028.

Key pipeline updates include the advancement of ABS-101 through clinical trials with an interim readout expected in H2 2025, and ABS-201 targeting Phase 1/2a initiation in early 2026. The company expanded its collaboration with Almirall, adding a second target for dermatological indications with potential milestone payments of up to $650 million.

Q2 2025 financial results showed revenue of $0.6 million (down from $1.3M in Q2 2024) and a net loss of $30.6 million (increased from $24.8M in Q2 2024). R&D expenses increased to $20.5 million, while SG&A expenses decreased to $8.5 million.

Positive

• Raised $64 million in gross proceeds strengthening balance sheet
• Extended cash runway into first half of 2028
• Expanded Almirall collaboration with potential milestone payments up to $650 million
• Strategic collaboration with AMD including $20 million equity investment
• Advancing multiple clinical programs with key readouts expected in 2025-2026
• Decreased SG&A expenses by $0.8 million year-over-year

Negative

• Revenue decreased 54% to $0.6 million in Q2 2025 from $1.3 million in Q2 2024
• Net loss increased 23% to $30.6 million from $24.8 million year-over-year
• R&D expenses increased 34% to $20.5 million from $15.3 million year-over-year

Insights

Biotechnology Financial Analyst

Absci strengthened its runway into 2028 with $64M funding while advancing its clinical pipeline and expanding a key partnership.

Absci's Q2 results reveal a significantly improved financial position following a $64 million capital raise, extending their runway into H1 2028 – a critical milestone for clinical-stage biotechs where cash management is paramount. This 48% boost to their pre-offering cash position of $117.5 million substantially de-risks their near-term financing needs.

Revenue declined to $0.6 million versus $1.3 million in Q2 2024, reflecting the typical lumpiness of partnership-driven revenue. More concerning is the widening quarterly net loss of $30.6 million, up from $24.8 million year-over-year, driven primarily by increased R&D expenses of $20.5 million (34% higher than Q2 2024). This burn rate acceleration indicates the company's pivot toward capital-intensive clinical development.

The expanded Almirall collaboration represents meaningful validation of Absci's AI platform. With potential milestone payments of up to $650 million across two programs (plus royalties), this partnership provides significant non-dilutive funding potential if development goals are met. The election of a second target following successful antibody delivery against a difficult-to-drug target demonstrates technical progress that could attract additional partners.

Most importantly, Absci's clinical pipeline is advancing with multiple catalysts ahead: ABS-101 (anti-TL1A) interim Phase 1 data expected later this year, ABS-201 (anti-PRLR) targeting the massive androgenetic alopecia market (affecting approximately 80 million Americans) slated to enter clinical trials in early 2026, and preclinical progress with ABS-301 and ABS-501. The timeline to efficacy data for these programs puts Absci in position to potentially demonstrate clinical validation of their AI-driven drug discovery approach within the next 12-18 months.

Strengthened balance sheet raising approximately $64 million in gross proceeds in July 2025; cash, cash equivalents, and short-term investments now sufficient to fund operations into the first half of 2028

Expanded ongoing collaboration with Almirall, with election of a second target focused on dermatological indications

VANCOUVER, Wash. and NEW YORK, Aug. 12, 2025 (GLOBE NEWSWIRE) -- Absci Corporation (Nasdaq: ABSI), a clinical-stage biopharmaceutical company advancing breakthrough therapeutics with generative AI, today reported financial and operating results for the quarter ended June 30, 2025.

“The past few months have been a period of strong execution for Absci, and we are positioned to build on this momentum,” said Sean McClain, Founder and CEO. “ABS-101 is advancing through clinical trials, ABS-201 is on track to enter the clinic early next year, and we recently announced a key milestone in our collaboration with Almirall. With a strengthened balance sheet and runway into the first half of 2028, we are well positioned to deliver on our mission.”

Recent Highlights

• Completed an underwritten public offering of common stock raising gross proceeds of approximately $50 million, and raised an additional approximately $14 million through Absci’s at-the-market facility in July 2025.
• Expanded ongoing AI Drug Discovery collaboration with Almirall with election of a second target focused on dermatological indications. The election follows the successful delivery of AI de novo designed, functional antibodies by Absci against a difficult-to-drug target — the first target nominated under the collaboration. The collaboration, originally announced in November 2023, combines Absci’s Integrated Drug Creation™ platform with Almirall’s dermatology expertise to accelerate the development of novel therapeutics for chronic and debilitating skin diseases. In addition to product royalties, Absci is eligible to receive up to approximately $650 million in upfront fees, R&D, and post-approval milestone payments across the two programs if all milestones are successfully completed.
• Continuing to advance all internal asset programs, with Phase 1 interim readout for ABS-101 (anti-TL1A) anticipated later this year and potential Phase 1/2a interim efficacy readout for ABS-201 (anti-PRLR) anticipated in the second half of 2026.
• Progressing on key initiatives in strategic collaboration with AMD, with objective of scaling Absci's AI Drug Creation platform using AMD Instinct™ accelerators and ROCm™ software. In January 2025, concurrent with this collaboration, AMD also made a $20 million strategic equity investment in Absci.

Internal Pipeline Updates, Anticipated Program Progress, and 2025 Outlook

• ABS-101 (potential best-in-class anti-TL1A antibody): The ongoing Phase 1 (ACTRN12625000212459p) randomized, double-blind, placebo-controlled, first-in-human study of single ascending doses of ABS-101 will evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) in healthy volunteers. The primary endpoint is safety and tolerability, with PK, PD, and immunogenicity serving as secondary endpoints. The Phase 1 interim data readout is expected in the second half of 2025.
• ABS-201 (potential best-in-class anti-PRLR antibody): ABS-201 is a potential best-in-class anti-PRLR antibody in development for androgenetic alopecia, an indication with significant unmet clinical need and a large potential patient population of approximately 80 million individuals in the U.S. alone. Absci has nominated a development candidate with a preclinical profile suggesting high affinity and potency, favorable safety and immunogenicity, extended half life for convenient infrequent dosing, and excellent developability and manufacturability. ABS-201 has the potential to offer a more efficacious, convenient, durable, and safe option as compared to current standard of care. Absci anticipates initiation of a Phase 1/2a clinical trial for ABS-201 in early 2026, with potential for an interim efficacy readout in the second half of 2026.
• ABS-301 (potential first-in-class antibody for undisclosed immuno-oncology target): ABS-301 is a fully human antibody designed to bind to a novel target discovered through Absci's Reverse Immunology platform. Absci has presented data for this program showing that expression of ABS-301’s target suggests broad potential in squamous cell carcinomas and beyond. For this program, Absci has optimized an antibody lead with high affinity and potency, and has successfully completed the first in vivo target validation study. The findings from the study demonstrate that signaling through the pathway drives a potent anti-tumor response, providing strong rationale for advancing into in vivo efficacy studies with ABS-301. These results support continued preclinical development and further exploration of ABS-301’s therapeutic potential.
• ABS-501 (potential best-in-class novel AI-designed anti-HER2 antibody): For this program, Absci has identified antibody leads using its zero-shot de novo AI technology with the following characteristics: novel epitope interactions, increased or equivalent affinity to trastuzumab in preclinical settings, efficacious against a trastuzumab-resistant xenograft tumor, and good developability.
• Drug Creation Partnerships: Absci continues to make further progress on its existing drug creation partnerships and anticipates signing one or more partnerships, including with a Large Pharma company, in 2025.

Absci continues to focus its investments and operations on advancing its internal pipeline of programs, alongside current and future partnered programs, while achieving ongoing platform improvements and operational efficiencies. In July 2025, Absci raised an additional approximately $64 million in gross proceeds from an underwritten public offering of common stock and strategic utilization of the company's at-the-market facility. Based on the company's current plans, Absci now believes its existing cash, cash equivalents, and short-term investments will be sufficient to fund its operations into the first half of 2028.

Second Quarter 2025 Financial Results

Revenue was $0.6 million for the three months ended June 30, 2025 compared to $1.3 million for the three months ended June 30, 2024.

Research and development expenses were $20.5 million for the three months ended June 30, 2025 compared to $15.3 million for the three months ended June 30, 2024. This increase was primarily driven by advancement of Absci's internal programs, including direct costs associated with external preclinical and clinical development, and an increase in personnel costs and stock compensation expense.

Selling, general, and administrative expenses were $8.5 million for the three months ended June 30, 2025 compared to $9.3 million for the three months ended June 30, 2024. This decrease was primarily due to a decrease in stock compensation expense.

Net loss was $30.6 million for the three months ended June 30, 2025, as compared to $24.8 million for the three months ended June 30, 2024.

Cash, cash equivalents, and short-term investments as of June 30, 2025 were $117.5 million, compared to $134.0 million as of March 31, 2025. In July 2025, Absci raised an additional approximately $64 million in gross proceeds, including $50 million through an underwritten public offering of common stock, and approximately $14 million through the company’s at-the-market facility.

Webcast Information

Absci will host a conference call to discuss its second quarter 2025 business updates and financial and operating results on Tuesday, August 12, 2025 at 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time. A webcast of the conference call can be accessed at investors.absci.com. The webcast will be archived and available for replay for at least 90 days after the event.

About Absci

Absci is advancing the future of drug discovery with generative design to create better biologics for patients, faster. Our Integrated Drug Creation™ platform combines cutting-edge AI models with a synthetic biology data engine, enabling the rapid design of innovative therapeutics that address challenging therapeutic targets. Absci’s approach leverages a continuous feedback loop between advanced AI algorithms and wet lab validation. Each cycle refines our data and strengthens our models, facilitating rapid innovation and enhancing the precision of our therapeutic designs. Alongside collaborations with top pharmaceutical, biotech, tech, and academic leaders, Absci is advancing its own pipeline of AI designed therapeutics. These include ABS-101, a potentially best-in-class antibody to treat inflammatory bowel disease (IBD), as well as other indications, and ABS-201, a groundbreaking innovation in hair regrowth with the potential to redefine treatment possibilities for androgenetic alopecia, commonly known as male and female pattern baldness. Absci is headquartered in Vancouver, WA, with an AI Research Lab in New York City, and Innovation Center in Switzerland. Learn more at www.absci.com or follow us on LinkedIn (@absci), X (@Abscibio) and YouTube.

Forward-Looking Statements

Certain statements in this press release that are not historical facts are considered forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements containing the words “will,” “pursues,” “anticipates,” “plans,” “believes,” “forecast,” “potential,” “goal,” “estimates,” “extends,” “expects,” and “intends,” or similar expressions. We intend these forward-looking statements, including statements regarding our expectations related to business operations, portfolio strategy, financial performance, and results of operations, our expectations and guidance related to the success of our partnerships, the gross use of cash, cash equivalents, and short-term investments, including revised guidance, our projected cash usage, needs, and runway, our expectations regarding the signing and number of additional partners and number of programs included in such partnerships, our technology development efforts and the application of those efforts, including for generalizing our platform, accelerating drug development timelines, improving the economics of drug discovery by lowering costs, and increasing the probability of success for drug development, our ability to execute with our partners to create differentiated antibody therapeutic candidates in an efficient manner, create and execute a successful development and commercialization strategy related to such candidates with current or future partners, and design and develop differentiated therapeutics to treat disease with unmet need, our ability to market our platform technologies to potential partners, and our internal asset programs, including our clinical development strategy, the progress and timing for various stages of development including advancement to lead stage, completion of pre-clinical studies, candidate selection, IND enabling studies, initiating clinical trials and the generation and disclosure of data related to these programs, the translation of preclinical results and data into product candidates, and the significance of preclinical results, including in comparison to competitor molecules and in leading to differentiated clinical efficacy or product profiles, to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Securities Exchange Act, and we make this statement for purposes of complying with those safe harbor provisions. These forward-looking statements reflect our current views about our plans, intentions, expectations, strategies, and prospects, which are based on the information currently available to us and on assumptions we have made. We can give no assurance that the plans, intentions, expectations, or strategies will be attained or achieved, and, furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a variety of risks and factors that are beyond our control, including, without limitation, risks and uncertainties relating to obtaining and maintaining necessary approvals from the FDA and other regulatory authorities, replicating in clinical trials promising or positive results observed in preclinical studies, our dependence on third parties to support our internal asset programs, including for the manufacture and supply of preclinical and clinical supplies of our product candidates or components thereof, our ability to effectively collaborate on research, drug discovery and development activities with our partners or potential partners, our existing and potential partners’ ability and willingness to pursue the development and commercialization of programs or product candidates under the terms of our partnership agreements, and overall market conditions and regulatory developments that may affect our and our partners’ activities under these agreements, along with those risks set forth in our most recent periodic report filed with the U.S. Securities and Exchange Commission, as well as discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the U.S. Securities and Exchange Commission. Except as required by law, we assume no obligation to update publicly any forward-looking statements, whether as a result of new information, future events, or otherwise.

Investor Contact:
Alex Khan
VP, Finance & Investor Relations
investors@absci.com

Media Contact:
press@absci.com
absci@methodcommunications.com

Absci Corporation Unaudited Condensed Consolidated Statements of Operations
		For the Three Months Ended June 30,								For the Six Months Ended June 30,
(In thousands, except for share and per share data)			2025				2024				2025				2024
Partner program revenue		$	593			$	1,270			$	1,772			$	2,168
Operating expenses
Research and development			20,458				15,261				36,822				27,497
Selling, general and administrative			8,528				9,346				18,000				18,090
Depreciation and amortization			3,000				3,384				6,072				6,800
Total operating expenses			31,986				27,991				60,894				52,387
Operating loss			(31,393	)			(26,721	)			(59,122	)			(50,219	)
Other income (expense)
Interest expense			(56	)			(150	)			(135	)			(326	)
Other income, net			1,011				2,121				2,469				3,832
Total other income, net			955				1,971				2,334				3,506
Loss before income taxes			(30,438	)			(24,750	)			(56,788	)			(46,713	)
Income tax benefit (expense)			(131	)			—				(127	)			(12	)
Net loss		$	(30,569	)		$	(24,750	)		$	(56,915	)		$	(46,725	)
Net loss per share: Basic and diluted		$	(0.24	)		$	(0.22	)		$	(0.45	)		$	(0.44	)
Weighted-average common shares outstanding: Basic and diluted			127,592,948				112,934,086				126,035,844				106,163,709

Absci Corporation Unaudited Condensed Consolidated Balance Sheets
		June 30,				December 31,
(In thousands, except for share and per share data)			2025				2024
ASSETS
Current assets:
Cash and cash equivalents		$	38,024			$	41,213
Restricted cash			16,209				15,947
Short-term investments			79,434				71,212
Accounts receivable, net			700				—
Prepaid expenses and other current assets			3,037				5,459
Total current assets			137,404				133,831
Operating lease right-of-use assets			3,457				3,968
Property and equipment, net			24,063				29,167
Intangibles, net			43,198				44,883
Restricted cash, long-term			1,054				1,054
Other long-term assets			716				705
TOTAL ASSETS		$	209,892			$	213,608
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable		$	8,206			$	3,529
Accrued expenses			5,715				6,842
Contingent consideration			12,750				12,750
Long-term debt			1,986				2,733
Operating lease obligations			1,705				1,608
Financing lease obligations			7				78
Deferred revenue			954				1,116
Total current liabilities			31,323				28,656
Long-term debt, net of current portion			161				1,257
Operating lease obligations, net of current portion			3,553				4,429
Other long-term liabilities			1,482				133
TOTAL LIABILITIES			36,519				34,475
STOCKHOLDERS' EQUITY
Preferred stock			—				—
Common stock			13				12
Additional paid-in capital			739,565				688,726
Accumulated deficit			(566,516	)			(509,601	)
Accumulated other comprehensive income (loss)			311				(4	)
TOTAL STOCKHOLDERS' EQUITY			173,373				179,133
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY		$	209,892			$	213,608

FAQ

What was Absci's (ABSI) revenue and net loss in Q2 2025?

Absci reported revenue of $0.6 million and a net loss of $30.6 million for Q2 2025, compared to revenue of $1.3 million and net loss of $24.8 million in Q2 2024.

How much capital did Absci (ABSI) raise in July 2025?

Absci raised $64 million in gross proceeds in July 2025, including $50 million through an underwritten public offering and $14 million through their at-the-market facility.

What are the key milestones expected for Absci's (ABSI) clinical pipeline?

Absci expects a Phase 1 interim readout for ABS-101 in H2 2025, initiation of Phase 1/2a trial for ABS-201 in early 2026, and a potential Phase 1/2a interim efficacy readout for ABS-201 in H2 2026.

What is the potential value of Absci's expanded collaboration with Almirall?

The Almirall collaboration could yield up to $650 million in upfront fees, R&D, and post-approval milestone payments across two programs, plus product royalties.

How long will Absci's current cash position fund operations?

With the recent $64 million capital raise, Absci's cash position is expected to fund operations into the first half of 2028.