Welcome to our dedicated page for Arbutus Biopharm news (Ticker: ABUS), a resource for investors and traders seeking the latest updates and insights on Arbutus Biopharm stock.
Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease, with a particular emphasis on chronic hepatitis B virus (cHBV) infection. The ABUS news feed highlights company announcements on clinical data, corporate strategy and intellectual property developments that shape the outlook for its pipeline and technology.
Investors and observers following ABUS news can find regular updates on imdusiran (AB-729), Arbutus’ RNAi therapeutic designed to reduce hepatitis B viral proteins and antigens including HBsAg. News items include results from Phase 1 and Phase 2a trials, such as reports of patients achieving what the company describes as functional cure, analyses of HBsAg and HBV DNA reductions, and presentations at major liver disease conferences including the European Association for the Study of the Liver (EASL) Congress and the American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting.
The ABUS news stream also covers developments related to AB-101, the company’s oral PD-L1 inhibitor candidate. Releases describe safety, tolerability and pharmacodynamic findings from the ongoing Phase 1a/1b trial in healthy volunteers and cHBV patients, including data on PD-L1 receptor occupancy and the absence of AB-101-related serious adverse events reported to date.
Another recurring theme in Arbutus news is its LNP intellectual property. Joint announcements with Genevant Sciences and company updates detail U.S. and international patent infringement actions against Moderna and Pfizer/BioNTech concerning the use of LNP technology in COVID-19 vaccines. Corporate news also includes board and executive changes, restructuring actions, and strategic decisions such as reacquiring Greater China rights to imdusiran and forming a Scientific Advisory Board of cHBV experts.
For those tracking ABUS stock and the company’s progress in hepatitis B and LNP technology, this news page provides a centralized view of clinical milestones, litigation updates and corporate developments as disclosed by Arbutus in its press releases.
Arbutus Biopharma (Nasdaq: ABUS) announced significant leadership changes, appointing Lindsay Androski as Chief Executive Officer, replacing Interim President and CEO Michael J. McElhaugh, effective immediately. Androski, an MIT-trained biologist with nearly 30 years of experience in biotechnology, law, and academia, will also join the company's board of directors.
The clinical-stage biopharmaceutical company has also appointed four new directors to its board: Robert Alan Beardsley, Joseph Bishop, Matthew Gline, and Anuj Hasija. All previous board members have stepped down, reducing the board to five members total. The company may consider adding directors with clinical development expertise in the coming months.
Androski stated that these leadership changes aim to enable "renewed focus on advancing the company's pipeline efficiently and maximizing the company's contributions to LNP delivery technology through Genevant." The company will temporarily pause investor meetings while the new leadership reviews development plans and strategic options for its hepatitis B programs.
Arbutus Biopharma (NASDAQ: ABUS) announced its 2025 corporate objectives and financial update. The company plans to initiate a Phase 2b clinical trial in the first half of 2025, following successful results from their IM-PROVE I Phase 2a trial. The trial showed a 50% functional cure rate in specific HBeAg-negative patients and 25% overall cure rate using imdusiran with interferon and NA therapy.
The company reported approximately $123 million in cash and investments as of December 31, 2024, expecting to reduce its net cash burn to $47-50 million in 2025 from about $65 million in 2024. This funding is projected to sustain operations through Q1 2028. Arbutus continues its litigation against Moderna and Pfizer/BioNTech regarding LNP technology patents, with Moderna's trial scheduled for September 2025.
Whitefort Capital, a major shareholder of Arbutus Biopharma (NASDAQ: ABUS) with a 6.8% stake, has sent a letter to the Board urging the company to pursue a license and collaboration agreement with a strategic partner for its Hepatitis B (HBV) portfolio. The letter follows confirmatory results from the IM-PROVE I Phase 2a trial, which showed a 50% functional cure rate in certain patients. Despite positive data, Arbutus' share price fell over 5%. Whitefort Capital advises against further dilutive equity issuances or ATM use for another year and requests a meeting with the Board to align on the company's future direction.
Arbutus Biopharma (Nasdaq: ABUS) has announced its participation in the H.C Wainwright @ Home virtual fireside chat series, scheduled for December 3, 2024, at 11:00 am ET. The event will be accessible via webcast on the company's investor relations website.
Arbutus is a clinical-stage biopharmaceutical company focused on developing a functional cure for chronic hepatitis B virus (cHBV) infection. Their approach combines HBV DNA suppression, surface antigen reduction, and immune response boosting. The company's pipeline includes imdusiran (AB-729), an RNAi therapeutic showing promising functional cure rates in combination therapy, and AB-101, an oral PD-L1 inhibitor currently in Phase 1a/1b clinical trials.
Arbutus Biopharma (ABUS) announced promising results from its IM-PROVE I Phase 2a clinical trial for imdusiran, its RNAi therapeutic for chronic hepatitis B virus (cHBV). When combined with 24 weeks of pegylated interferon and nucleos(t)ide analogue therapy, the treatment achieved a 50% functional cure rate (3/6 patients) in patients with baseline HBsAg levels below 1000 IU/mL, and a 25% overall functional cure rate (3/12 patients). The combination therapy was generally safe and well-tolerated, with no serious adverse events. The data will be presented at AASLD – The Liver Meeting® on November 18, 2024.
Arbutus Biopharma and Barinthus Bio announced new preliminary data from Phase 2a IM-PROVE II trial for chronic hepatitis B treatment. The study evaluated the combination of imdusiran, VTP-300, and low-dose nivolumab. Key findings show that 23% of participants receiving the triple combination achieved HBsAg loss by Week 48, with significantly greater mean declines in HBsAg levels (p <0.017) compared to other cohorts. The treatment regimen was generally well-tolerated with no immune-related adverse events. The trial included 22 participants in Group C, with 13 eligible for nivolumab treatment.
Arbutus Biopharma (Nasdaq: ABUS), a clinical-stage biopharmaceutical company focused on developing a functional cure for chronic hepatitis B virus (cHBV) infection, has announced its participation in the Jefferies London Healthcare Conference. The company will conduct a fireside chat on November 21, 2024 at 12:00 pm GMT / 7:00 am EST. Investors can access the live webcast through the company's investor relations website, with an archived replay available for a time after the event.
Arbutus Biopharma (ABUS) reported Q3 2024 financial results with a net loss of $19.7 million ($0.10 per share). Revenue decreased to $1.3 million from $4.7 million in Q3 2023. The company maintains a strong cash position of $130.8 million, expected to fund operations into Q4 2026.
Clinical progress includes promising data from the IM-PROVE I Phase 2a trial, where 33.3% of patients achieved HBsAg loss. The company's oral PD-L1 inhibitor, AB-101, showed positive safety data and dose-dependent receptor occupancy in healthy subjects, now advancing to cHBV patient dosing.
Arbutus Biopharma (Nasdaq: ABUS) has announced it will release its third quarter 2024 financial results and provide a corporate update on Wednesday, November 6, 2024. The company will issue a press release at 7:30 a.m. ET, followed by a conference call and webcast at 8:45 a.m. ET. Arbutus is a clinical-stage biopharmaceutical company focused on developing a functional cure for chronic hepatitis B virus (cHBV) through its pipeline of compounds, including the RNAi therapeutic imdusiran and oral PD-L1 inhibitor AB-101.
Arbutus Biopharma (Nasdaq: ABUS) announced that clinical data for imdusiran, an RNAi therapeutic for chronic hepatitis B virus (cHBV) infection, will be presented in four posters at the AASLD - The Liver Meeting® 2024. Two late-breaking posters will feature data from the IM-PROVE I and IM-PROVE II Phase 2a clinical trials.
Key findings from regular abstracts include:
- Imdusiran with interferon treatment showed distinct phases of immune biomarker signatures, with Th1 activation during imdusiran lead-in and Th2 signatures associated with HBsAg seroconversion.
- The imdusiran target site is highly conserved in cHBV subjects, with in vitro testing confirming activity against tested variants.
Imdusiran is designed to reduce all HBV viral proteins and antigens, potentially enabling immune system reawakening. It is currently in multiple Phase 2a clinical trials.