Welcome to our dedicated page for Arbutus Biopharm news (Ticker: ABUS), a resource for investors and traders seeking the latest updates and insights on Arbutus Biopharm stock.
Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease, with a particular emphasis on chronic hepatitis B virus (cHBV) infection. The ABUS news feed highlights company announcements on clinical data, corporate strategy and intellectual property developments that shape the outlook for its pipeline and technology.
Investors and observers following ABUS news can find regular updates on imdusiran (AB-729), Arbutus’ RNAi therapeutic designed to reduce hepatitis B viral proteins and antigens including HBsAg. News items include results from Phase 1 and Phase 2a trials, such as reports of patients achieving what the company describes as functional cure, analyses of HBsAg and HBV DNA reductions, and presentations at major liver disease conferences including the European Association for the Study of the Liver (EASL) Congress and the American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting.
The ABUS news stream also covers developments related to AB-101, the company’s oral PD-L1 inhibitor candidate. Releases describe safety, tolerability and pharmacodynamic findings from the ongoing Phase 1a/1b trial in healthy volunteers and cHBV patients, including data on PD-L1 receptor occupancy and the absence of AB-101-related serious adverse events reported to date.
Another recurring theme in Arbutus news is its LNP intellectual property. Joint announcements with Genevant Sciences and company updates detail U.S. and international patent infringement actions against Moderna and Pfizer/BioNTech concerning the use of LNP technology in COVID-19 vaccines. Corporate news also includes board and executive changes, restructuring actions, and strategic decisions such as reacquiring Greater China rights to imdusiran and forming a Scientific Advisory Board of cHBV experts.
For those tracking ABUS stock and the company’s progress in hepatitis B and LNP technology, this news page provides a centralized view of clinical milestones, litigation updates and corporate developments as disclosed by Arbutus in its press releases.
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Arbutus Biopharma (Nasdaq: ABUS) announced exciting clinical data at the Global Hepatitis Summit 2023 regarding their HBV treatments AB-729 and AB-161. Seven out of nine patients with chronic hepatitis B (cHBV) who were treated with AB-729 maintained low HBV DNA and HBsAg levels for over 1.5 years without needing nucleos(t)ide analogue therapy. The treatment showed no adverse effects during follow-up. Additionally, AB-161 demonstrated strong anti-HBV activity in preclinical models, effectively reducing HBV RNA and HBsAg. Both AB-729 and AB-161 are positioned as pivotal components in developing a potential functional cure for cHBV. Ongoing Phase 2a clinical trials for AB-729 are set to report preliminary data this year.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced a verbal notification from the U.S. FDA that its Investigational New Drug (IND) application for AB-101, an oral PD-L1 inhibitor aimed at treating chronic hepatitis B virus (HBV) infection, has been placed on clinical hold. An official Clinical Hold letter is expected within 30 days, and as a result, Arbutus will not report initial data from the Phase 1 clinical trial in late 2023. AB-101 is designed to enhance the immune response in chronic HBV patients and could potentially lead to a functional cure when combined with other therapies. However, the company acknowledges the hold may impact the timing and future development of AB-101, adding uncertainty to its ongoing clinical programs.