Welcome to our dedicated page for Arbutus Biopharm news (Ticker: ABUS), a resource for investors and traders seeking the latest updates and insights on Arbutus Biopharm stock.
Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease, with a particular emphasis on chronic hepatitis B virus (cHBV) infection. The ABUS news feed highlights company announcements on clinical data, corporate strategy and intellectual property developments that shape the outlook for its pipeline and technology.
Investors and observers following ABUS news can find regular updates on imdusiran (AB-729), Arbutus’ RNAi therapeutic designed to reduce hepatitis B viral proteins and antigens including HBsAg. News items include results from Phase 1 and Phase 2a trials, such as reports of patients achieving what the company describes as functional cure, analyses of HBsAg and HBV DNA reductions, and presentations at major liver disease conferences including the European Association for the Study of the Liver (EASL) Congress and the American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting.
The ABUS news stream also covers developments related to AB-101, the company’s oral PD-L1 inhibitor candidate. Releases describe safety, tolerability and pharmacodynamic findings from the ongoing Phase 1a/1b trial in healthy volunteers and cHBV patients, including data on PD-L1 receptor occupancy and the absence of AB-101-related serious adverse events reported to date.
Another recurring theme in Arbutus news is its LNP intellectual property. Joint announcements with Genevant Sciences and company updates detail U.S. and international patent infringement actions against Moderna and Pfizer/BioNTech concerning the use of LNP technology in COVID-19 vaccines. Corporate news also includes board and executive changes, restructuring actions, and strategic decisions such as reacquiring Greater China rights to imdusiran and forming a Scientific Advisory Board of cHBV experts.
For those tracking ABUS stock and the company’s progress in hepatitis B and LNP technology, this news page provides a centralized view of clinical milestones, litigation updates and corporate developments as disclosed by Arbutus in its press releases.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has announced its schedule for the first quarter 2023 financial results and corporate update, set for May 4, 2023. The press release will be available at 7:30 a.m. ET, followed by a conference call/webcast at 8:45 a.m. ET. Arbutus specializes in developing innovative therapeutics for viral diseases, focusing on Hepatitis B, SARS-CoV-2, and other coronaviruses. The company is advancing its lead compound, AB-729, which is currently being tested in phase 2 clinical trials, and is also pursuing oral agents for coronaviruses. An archived webcast will be accessible on the company’s website after the event.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced two oral presentations at the Global Hepatitis Summit 2023 in Paris, scheduled for April 27, 2023. The presentations will cover significant findings related to the company's HBV research.
The first presentation focuses on AB-729, showcasing results from 48 weeks of therapy leading to substantial declines in HBsAg levels among patients. Follow-up data indicates sustained low HBV DNA levels even after therapy cessation.
The second presentation highlights AB-161, an oral HBV inhibitor displaying strong antiviral activity in preclinical studies. Both compounds aim to contribute toward a functional cure for chronic hepatitis B.
Additionally, Arbutus is in multiple Phase 2a trials for AB-729, emphasizing the need for innovative treatments targeting HBV, which affects over 290 million people globally.
Arbutus Biopharma Corporation (Nasdaq: ABUS) and Genevant Sciences filed a lawsuit against Pfizer (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) in the U.S. District Court for New Jersey, claiming patent infringement related to COVID-19 mRNA-LNP vaccines. The lawsuit seeks damages for the unlicensed use of patented lipid nanoparticle (LNP) delivery technologies that are crucial for mRNA vaccine efficacy. Arbutus asserts that the rapid development of Pfizer-BioNTech's vaccines depended on their patented technologies, which are vital for delivering mRNA safely and effectively. Arbutus intends to protect its intellectual property vigorously.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has initiated the Phase 1 clinical trial for AB-161, an oral RNA destabilizer aimed at providing a functional cure for hepatitis B virus (HBV). The first subject has been dosed, and initial data is anticipated in the second half of 2023. This double-blind, placebo-controlled trial will evaluate safety and tolerability in healthy subjects, with unique cohorts receiving escalating doses. AB-161 targets host proteins involved in stabilizing HBV RNA, potentially leading to reduced viral replication and lower HBsAg levels.
Chronic HBV affects over 290 million globally, with significant unmet medical needs.
Arbutus Biopharma Corporation (Nasdaq: ABUS) presented preclinical data for AB-343, a novel oral SARS-CoV-2 Mpro inhibitor, at the 36th International Conference on Antiviral Research. AB-343 is designed as a ritonavir-free treatment for COVID-19 and shows promise against circulating variants. The drug exhibited potent antiviral activity (EC50 ~ 20nM) and superior binding characteristics compared to existing treatments like nirmatrelvir. Arbutus plans to advance AB-343 into IND-enabling studies, aiming for a Phase 1 clinical trial in H2 2023. These developments highlight Arbutus' commitment to tackling COVID-19 through innovative therapeutics.
Arbutus Biopharma Corporation (Nasdaq: ABUS) reported significant advancements in its clinical pipeline during their year-end 2022 update. Notably, AB-729, an RNAi therapeutic for chronic HBV, is undergoing multiple Phase 2a trials, with preliminary data expected in 2023. The company also plans to initiate Phase 1 trials for oral candidates AB-101 and AB-161, along with AB-343 targeting coronaviruses. Financially, Arbutus ended 2022 with $184.3 million in cash. Total revenue surged to $39 million, primarily from a $26 million license agreement. However, R&D expenses rose to $84.4 million, leading to a net loss of $69.5 million, an improvement over the previous year's loss.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced its upcoming fourth quarter and year-end 2022 financial results, scheduled for March 2, 2023. A press release will be issued at 7:30 a.m. ET, followed by a conference call/webcast at 8:45 a.m. ET. The company focuses on developing therapeutics for viral diseases including Hepatitis B and SARS-CoV-2, with lead compound AB-729 currently in phase 2 trials. Arbutus aims to provide a functional cure for chronic HBV. Investors can access the conference call via a registration link or through the company's website.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has announced participation in three investor conferences: the SVB Securities Global Biopharma Conference from February 14-16, 2023, the Cowen 43rd Annual Health Care Conference with a formal presentation on March 7, and the Jefferies Biotech on the Bay Summit from March 16-17, 2023. The company focuses on developing innovative therapeutics for viral diseases, particularly Hepatitis B and coronaviruses. Its lead compound, AB-729, is currently under evaluation in multiple phase 2 clinical trials. Access to webcasts for the presentations will be available on the Arbutus website.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced that Dr. Tram Tran has resigned from its Board of Directors, effective February 26, 2023, to transition into public service. Dr. Tran, a board member since November 2021, was part of the Executive Compensation and Human Resources Committee, contributing her expertise in virology to the company's hepatitis B and COVID-19 pipeline. The resignation was amicable and not due to any disagreements. The company is initiating a search for a new independent board member to fill her vacancy. Arbutus focuses on developing therapeutics for Hepatitis B and coronaviruses, including its lead candidate, AB-729.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced its 2023 objectives, focusing on advancing its HBV assets, AB-101 and AB-161, into Phase 1 clinical trials and expecting data from ongoing AB-729 trials. The company anticipates significant data from multiple Phase 2a trials in 2023 and plans to advance AB-343, a new coronavirus asset, into clinical trials. As of December 31, 2022, Arbutus had approximately $185 million in cash, providing a runway into Q4 2024. The company aims to address unmet needs in HBV and coronavirus treatment.