Abivax to Present Data on Obefazimod at United European Gastroenterology (UEG) Week 2026

Abivax (ABVX) will present seven obefazimod abstracts at United European Gastroenterology Week, taking place October 17–20, 2026, in Barcelona, Spain.

Rhea-AI Summary

Abivax (ABVX) will present seven obefazimod abstracts at United European Gastroenterology Week, taking place October 17–20, 2026, in Barcelona, Spain.

The program includes four oral presentations and three posters covering Phase 3 ABTECT Maintenance and Induction trials in moderately to severely active ulcerative colitis, long-term Phase 2 follow-up, and preclinical research on inflammation, fibrosis and tumor activity. Clinical presentations include the 44-week maintenance trial and three-year interim analyses following dose reduction to 25 mg in the Phase 2 program. Presentations will be available on Abivax’s publications webpage after the meeting concludes.

Key Terms

ulcerative colitis, double-blind, placebo-controlled, dose de-escalation

4 terms

ulcerative colitis medical

"treatment of moderately to severely active ulcerative colitis"

A long-term inflammatory disease that causes repeated sores and irritation in the large intestine, leading to symptoms such as abdominal pain, urgent diarrhea, and fatigue. For investors, it matters because the condition creates a steady need for effective treatments, influences the size of drug and medical-device markets, and makes clinical trial results, regulatory decisions and treatment approvals material to companies’ revenue prospects—like watching for fixes to a recurring leak in an important building system.

double-blind medical

"Phase 3, randomized, double-blind, placebo-controlled, 44-week maintenance trial"

A double-blind process means that neither the people conducting an activity nor the people involved know certain key details, such as who is receiving a treatment or a placebo. This approach helps prevent bias from influencing the results, making the outcome more trustworthy. For investors, it ensures that decisions or judgments are based on unbiased information rather than preconceived opinions or expectations.

placebo-controlled medical

"randomized, double-blind, placebo-controlled, 44-week maintenance trial"

"Placebo-controlled" describes a testing method where one group receives the actual treatment or intervention, while another group receives a harmless, inactive version called a placebo. This approach helps determine whether the real treatment has genuine effects beyond psychological expectations. For investors, understanding this ensures confidence that reported benefits are real and not influenced by bias or false perceptions.

dose de-escalation medical

"after dose de-escalation to 25 mg"

A planned or reactive lowering of the amount of a drug given, used in clinical development or patient treatment to reduce side effects or identify the lowest dose that still produces the desired effect. In trials, dose de-escalation can be a protocol-defined step in dose‑finding studies (for example to move from an initial higher dose down to a safer or minimally effective dose across cohorts); in clinical care it can mean reducing a patient’s dose because of toxicity or tolerability. It differs from routine dose titration in that it is typically focused on safety thresholds or establishing a minimal effective dose rather than gradual upward adjustment.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Abivax to Present Data on Obefazimod at United European Gastroenterology (UEG) Week 2026

Four oral presentations and three posters build upon Phase 3 ABTECT Maintenance and Induction programs in ulcerative colitis, long-term Phase 2 findings, and preclinical anti-fibrotic research

PARIS, France – September 30, 2026 – 10:05 PM CEST – Abivax SA (Euronext Paris: FR0012333284 – ABVX / Nasdaq: ABVX) (“Abivax” or the “Company”), a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced that seven scientific abstracts on obefazimod, its lead drug candidate for the treatment of moderately to severely active ulcerative colitis (UC), will be presented at the United European Gastroenterology (UEG) Week 2026 meeting, taking place October 17–20, 2026, in Barcelona, Spain. These presentations will highlight data from the Phase 3 ABTECT Maintenance and Induction trials in UC, long-term follow-up from the Phase 2 program in UC, and preclinical research on obefazimod's anti-fibrotic and anti-tumor activity.

"The data being presented at UEG Week add to the growing understanding of obefazimod and its potential in inflammatory bowel disease,” said Marc de Garidel, MBA, Chief Executive Officer of Abivax. “These findings reinforce our confidence in obefazimod’s potential to address significant unmet needs for patients living with inflammatory bowel disease."

Chris Rabbat, PhD, Chief Medical Officer of Abivax, added, "The seven accepted abstracts reflect the breadth and maturity of the obefazimod program, spanning Phase 3 maintenance results, long-term Phase 2 efficacy and safety data, and preclinical findings on inflammation and fibrosis. We look forward to sharing these findings with the global gastroenterology community and highlighting the growing clinical and scientific evidence supporting obefazimod.”

Visit the publications page of Abivax’s website to view the presentations after the conclusion of the meeting.

Data to be Presented:

Date & Time	Session	Room	Abstract #	Title	Presenter
Oral Presentation
October 19, 10:50–11:00	Hot Topics in Clinical GI Research	D3	OP097	Efficacy and safety of obefazimod in patients with moderately to severely active ulcerative colitis: results from the Phase 3, randomized, double-blind, placebo-controlled, 44-week maintenance trial (ABTECT-Maintenance)	Prof. Bruce E. Sands, MD, MS Professor of Medicine at Icahn School of Medicine at Mount Sinai
October 19, 10:50–11:00	Molecular Trajectories of Disease and Drug Responses in IBD	A1	OP091	Obefazimod increases miR-124 expression to consistently modulate inflammation and fibrosis across preclinical models	Prof. Silvio Danese, MD, PhD Professor of Gastroenterology and Director of Gastroenterology and Gastrointestinal Endoscopy Unit at IRCCS San Raffaele Hospital
October 19, 12:00–12:10	Long-term Outcomes of Interventional Trials in IBD	A2	OP107	Long-term efficacy and persistence with obefazimod after dose de-escalation to 25 mg: 3-year interim analysis in patients with moderately to severely active ulcerative colitis completing Week 144, stratified by prior advanced therapy experience: results from the Phase 2 program	Prof. Bruce E. Sands, MD, MS Professor of Medicine at Icahn School of Medicine at Mount Sinai
October 20, 12:20–12:30	Looking into the Future: Novel Therapeutics in IBD, Part 2	B3	OP260	Efficacy of obefazimod in Phase 3 ABTECT-Maintenance trial: results of 44-week therapy in subsets of patients with and without prior inadequate response to advanced therapies	Prof. Silvio Danese, MD, PhD Professor of Gastroenterology and Director of Gastroenterology and Gastrointestinal Endoscopy Unit at IRCCS San Raffaele Hospital
Moderated Poster
October 18, 17:24–17:30	Outcomes from RCT in IBD (II)	Hall 7 – Poster Stage 2	MP0294	Efficacy, persistence, and safety of obefazimod in patients with moderately to severely active ulcerative colitis: 3-year interim analysis following dose de-escalation to 25 mg in the open-label maintenance Phase 2 study	Bram Verstockt, MD, PhD Associate Professor and Principal Investigator at KU Leuven
October 18, 17:36–17:42	Outcomes from RCT in IBD (II)	Hall 7 – Poster Stage 2	MP0296	Symptoms of bowel urgency and nocturnal bowel movements are linked with improvement in clinical outcomes among patients with moderately to severely active ulcerative colitis treated with obefazimod: pooled results from the 8-week ABTECT Phase 3 induction trials	David T. Rubin, MD Professor of Medicine and Chief, Gastroenterology, Hepatology and Nutrition at The University of Chicago
E-Poster
October 17, 9:00 – 9:00	IBD, including microscopic colitis	Hall 7	PP1180	Obefazimod reduces inflammation-driven tumor burden in a murine model of colitis-associated cancer	Prof. Silvio Danese, MD, PhD Professor of Gastroenterology and Director of Gastroenterology and Gastrointestinal Endoscopy Unit at IRCCS San Raffaele Hospital

About Abivax 

Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax’s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis.

Contact:
Patrick Malloy
SVP, Investor Relations
Abivax SA
patrick.malloy@abivax.com
+1 847 987 4878

Media Contact:
LifeSci Communications
Karissa Baltz, PhD
Associate Director
LSC_ABIVAX@lifescicomms.com

FORWARD-LOOKING STATEMENTS

This press release contains forward-looking statements, forecasts and estimates, including those relating to the Company’s business. Words such as “anticipate,” “expect,” “on track,” “potential,” “will” and variations of such words and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements concerning the potential therapeutic benefit of obefazimod and obefazimod’s potential to address significant unmet needs for patients living with inflammatory bowel disease, and other statements that are not historical fact. Although Abivax’s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks, contingencies and uncertainties, many of which are difficult to predict and generally beyond the control of Abivax, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. A description of these risks, contingencies and uncertainties can be found in the documents filed by the Company with the French Autorité des Marchés Financiers pursuant to its legal obligations including its universal registration document (Document d’Enregistrement Universel) and in its Annual Report on Form 20-F for the fiscal year ended December 31, 2025 filed with the U.S. Securities and Exchange Commission on March 23, 2026, under the caption “Risk Factors.” These risks, contingencies and uncertainties include, among other things, the uncertainties inherent in research and development, future clinical data and analysis, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug candidate, as well as their decisions regarding labeling and other matters that could affect the availability or commercial potential of such product candidates, and the availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements. Special consideration should be given to the potential hurdles of clinical and pharmaceutical development, including further assessment by the Company and regulatory agencies and IRBs/ethics committees following the assessment of preclinical, pharmacokinetic, carcinogenicity, toxicity, CMC and clinical data. Furthermore, these forward-looking statements, forecasts and estimates are made only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Abivax disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any subsequent changes that the Company becomes aware of, except as required by law. Information about pharmaceutical products (including products currently in development) that is included in this press release is not intended to constitute an advertisement. This press release is for information purposes only, and the information contained herein does not constitute either an offer to sell or the solicitation of an offer to purchase or subscribe for securities of the Company in any jurisdiction. Similarly, it does not give and should not be treated as giving investment advice. It has no connection with the investment objectives, financial situation or specific needs of any recipient. It should not be regarded by recipients as a substitute for exercise of their own judgment. All opinions expressed herein are subject to change without notice. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.

Attachment

• 2026_09_30_Abivax to Present Data on Obefazimod at UEG Week 2026