Adagene Inc. develops antibody-based cancer immunotherapies as a Nasdaq-listed foreign issuer whose securities trade as ADSs under ADAG. The company uses computational biology and artificial intelligence through its proprietary Dynamic Precision Library platform, including NEObody, SAFEbody and POWERbody technologies, to design masked and engineered antibody programs.
Recurring company updates center on muzastotug (ADG126), a masked anti-CTLA-4 SAFEbody, clinical data in microsatellite stable colorectal cancer and hepatocellular carcinoma, combination studies with checkpoint and bispecific therapies, and FDA Fast Track designation in MSS metastatic colorectal cancer. Other developments include scientific meeting presentations, SAFEbody collaborations and licensing, advisory board changes, financial results and ADS capital offerings.
Adagene Inc. (Nasdaq: ADAG) presented promising results for its anti-CTLA-4 SAFEbody® ADG126 (Muzastotug) in combination with KEYTRUDA® (Pembrolizumab) at the ESMO Congress. The phase 1b/2 trial focused on advanced/metastatic microsatellite-stable (MSS) colorectal cancer (CRC) patients. Key findings include:
1. Doubled confirmed partial responses to four since ASCO GI in MSS CRC patients without liver and peritoneal metastases, with a 24% overall response rate.
2. Median progression-free survival of 8.5 months in patients without liver and peritoneal metastases at ADG126 10 mg/kg Q3W dose.
3. 12-month overall survival rates of 74% for patients without liver metastases and 82% for those without liver and peritoneal metastases at 10 mg/kg dose.
4. Maintained safety profile with only 16% Grade 3 TRAEs in patients treated with ADG126 10 mg/kg Q3W combined with pembrolizumab.
Adagene Inc. (Nasdaq: ADAG), a clinical-stage biotechnology company, has announced its participation in several upcoming investor conferences in New York City this September. The company's management will host investor meetings, and Peter Luo, Ph.D., Adagene's Chairman, CEO, and President of R&D, will present at three major events:
1. Morgan Stanley 22nd Annual Global Healthcare Conference on September 6
2. H.C. Wainwright 26th Annual Global Investment Conference on September 9
3. 2024 Cantor Fitzgerald Global Healthcare Conference on September 18
Live webcasts of the presentations will be available on Adagene's website, with replays accessible for at least 30 days. These conferences provide an opportunity for Adagene to showcase its platform-driven approach to discovering and developing novel antibody-based therapies.
Adagene Inc. (Nasdaq: ADAG) reported financial results for H1 2024 and provided corporate updates. Highlights include:
1. ADG126, a masked anti-CTLA-4 SAFEbody, shows potential best-in-class profile in combination with pembrolizumab.
2. Poster presentation planned at ESMO Congress 2024 for ADG126 in metastatic MSS colorectal cancer.
3. Cash balance of $95.7 million funds operations into 2026.
4. Net revenue was nil for H1 2024, compared to $17.3 million in H1 2023.
5. R&D expenses decreased 31% to $14.7 million in H1 2024.
6. Net loss was $17.0 million in H1 2024, compared to $4.1 million in H1 2023.
7. Non-GAAP net loss was $14.5 million in H1 2024.
Adagene has announced a poster presentation at the European Society for Medical Oncology (ESMO) Congress, scheduled for 13-17 September 2024 in Barcelona, Spain.
The presentation will highlight results from an ongoing phase 1b/2 trial of their masked anti-CTLA-4 SAFEbody, ADG126 (muzastotug), in combination with pembrolizumab. The trial focuses on treating patients with metastatic microsatellite stable colorectal cancer (MSS CRC). The poster, titled 'Increased Therapeutic Index of Muzastotug (Muza, ADG126), a Masked Anti-CTLA-4 SAFEbody, in Combination with Pembrolizumab (Pembro) Enables Significant Clinical Benefits and Supports Further Clinical Development in Patients with Metastatic MSS CRC', will be available on Adagene's website following ESMO's embargo policy.
Adagene (Nasdaq: ADAG) will participate in multiple investor conferences in June 2024. CEO and Chairman, Peter Luo, Ph.D., will provide company updates, particularly on the ADG126 SAFEbody® anti-CTLA-4 progress. The Jefferies Global Healthcare Conference in New York City is scheduled for June 5, followed by the Goldman Sachs 45th Annual Global Healthcare Conference in Miami on June 13. Lastly, the HC Wainwright 2nd Annual Immune Cell Engager Virtual Conference will be held on June 25. Investors can access live webcasts and replays on Adagene's website.
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