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Grey Matters Health Inc., formerly Algernon Health Inc. and Algernon Pharmaceuticals Inc., reports healthcare developments tied to its shift toward Alzheimer’s disease diagnostics and dedicated brain PET imaging. News for AGNPF has centered on NovaScan Neuroimaging Clinics, U.S. brain PET scanning center plans, CareMiBrain™ scanner technology, beta-amyloid detection, and clinical uses across dementia and other neurologic conditions.
Company updates also cover capital-structure actions, including name changes and share consolidation, equipment financing, service partnerships, clinic leases, and shareholder or governance matters. The company has also described Algernon NeuroScience’s regulated botanical wellness program involving a proprietary form of DMT and its equity interest in Seyltx, which is advancing Ifenprodil for chronic cough.
Algernon Pharmaceuticals has advanced its research on NP-120 (Ifenprodil) targeting idiopathic pulmonary fibrosis (IPF) with cough. The company has filed for Orphan Designation with the U.S. FDA, which provides incentives for rare diseases affecting fewer than 200,000 patients. In a Phase 2a study, Ifenprodil showed no worsening lung function and significant improvements in cough frequency and patient-reported quality of life. Algernon aims to expedite Ifenprodil's development as a potential new therapy, addressing the urgent need as IPF has a high mortality rate.
Algernon Pharmaceuticals has received approval for a Phase 1 clinical study of an intravenous formulation of DMT for stroke treatment in the Netherlands. The trial, set to start screening soon, aims to evaluate safety, tolerability, and pharmacokinetics of DMT while gathering data for future studies. Previous preclinical studies indicated that DMT may promote neurogenesis and reduce tissue damage post-stroke. The study will involve up to 60 healthy volunteers, and there is optimism regarding the safety of DMT based on earlier trials.
Algernon Pharmaceuticals announced its role as the Headline Sponsor for the Wonderland 2022 conference in Miami from November 3-5. CEO Christopher J. Moreau will present two keynotes on November 4 and 5. Algernon is advancing its clinical research on DMT for stroke treatment and aims to initiate a Phase 1 trial in Q4 2022. The company has completed its intravenous formulation, applied for ethics approval, and will study DMT's safety and efficacy in healthy volunteers.
Algernon Pharmaceuticals has announced positive results from its Phase 2a study of NP-120 (Ifenprodil) for treating idiopathic pulmonary fibrosis and chronic cough. The trial met its co-primary endpoint of lung function preservation, showing no worsening of forced vital capacity over 12 weeks.
Secondary endpoints indicated stable diffusion capacity and improved cough-related metrics. Ifenprodil was well tolerated, achieving over 90% compliance. Upcoming presentations include the 21st International Colloquium on Lung and Airway Fibrosis in October 2022. The company plans to seek FDA orphan designation and file for a Phase 2b trial.
On August 23, 2022, Algernon Pharmaceuticals announced that its largest shareholder, AlphaNorth Asset Management, acquired 150,000 shares through a private placement, raising its ownership to over 13%. Steve Palmer, CEO of AlphaNorth, highlighted that the recent share price weakness provided a good opportunity for investment and expressed strong support for Algernon's drug pipeline. CEO Christopher J. Moreau welcomed this endorsement, emphasizing the company's focus on advancing its clinical drug development operations.
Algernon Pharmaceuticals is pleased to announce its participation in the 9th American Cough Conference in June 2023, where it will present results from its Phase 2a Study of NP-120 (Ifenprodil) for idiopathic pulmonary fibrosis and chronic cough. Ifenprodil, an NMDA receptor antagonist, could pioneer new treatment avenues for these conditions. Dr. Peter Dicpinigaitis noted the drug's promising potential as a first-in-class therapy. The conference, which focuses on cough research and management, occurs biennially, highlighting the significance of this presentation.
Algernon Pharmaceuticals reported enhanced results from its Phase 2a study of NP-120 (Ifenprodil) for idiopathic pulmonary fibrosis (IPF) and chronic cough. The analysis revealed a 32.0% reduction in mean 24-hour cough counts after 4 weeks and a 39.5% reduction at 12 weeks. Similarly, awake cough counts dropped by 30.2% and 37.4% respectively. Dr. Jacky Smith lauded the results, emphasizing Ifenprodil's potential, especially in IPF patients where treatment has been challenging. CEO Christopher J. Moreau noted Ifenprodil's growing efficacy could mean greater results in chronic cough cases without IPF.
Algernon Pharmaceuticals has announced promising topline data from its Phase 2 proof of concept study of NP-120 (Ifenprodil) as a treatment for idiopathic pulmonary fibrosis (IPF) and chronic cough. The study showed 65% of patients achieved stable or improved forced vital capacity (FVC) compared to an expected placebo effect of 40% (p=0.0225). Additionally, 30% of subjects demonstrated a significant reduction in cough frequency. The company plans to file a pre-IND application for a Phase 2b study with the FDA, indicating a potential new treatment pathway for IPF patients.
Algernon Pharmaceuticals Inc. (CSE: AGN, OTCQB: AGNPF) announced progress in its chronic kidney disease (CKD) research program using Repirinast, previously an asthma drug. In pre-clinical tests, Repirinast significantly reduced kidney fibrosis by 50%. The company is also exploring its use for acute interstitial nephritis. Manufacturing is underway, with a toxicology study planned post-synthesis, followed by a Phase 1 study set for Q4 2022. The global CKD drug market is projected to reach $15.8 billion by 2024, reflecting a substantial opportunity for Algernon's research endeavors.
Algernon Pharmaceuticals (CSE: AGN, OTCQB: AGNPF) announced an update on its Phase 1 clinical study of AP-188 (DMT), a psychedelic compound. The Company is finalizing the intravenous formulation needed for the study, set to begin in September 2022, with the Centre for Human Drug Research in the Netherlands. This trial aims to evaluate the safety, tolerability, and pharmacokinetics of DMT through prolonged infusion. The findings will inform future studies on DMT's potential in treating ischemic stroke and rehabilitation.