Welcome to our dedicated page for Algernon Health news (Ticker: AGNPF), a resource for investors and traders seeking the latest updates and insights on Algernon Health stock.
Algernon Health Inc. (AGNPF), formerly Algernon Pharmaceuticals Inc., generates news that reflects its transition from a purely clinical-stage pharmaceutical developer to a healthcare company focused on brain-specific PET neuroimaging clinics and neurological programs. Company announcements highlight its plans to build a network of specialized clinics in North America for the early-stage detection of Alzheimer’s disease and other brain disorders, as well as updates on its drug development and subsidiary activities.
Investors and observers following AGNPF news will see disclosures about neuroimaging initiatives, including equipment orders and financing agreements for U.S. FDA-cleared brain PET systems, partnerships with imaging technology providers, and franchise and licensing arrangements obtained through the acquisition of NoBrainer Imaging Centers, Inc. These items outline how Algernon intends to deploy dedicated clinics and expand access to brain PET imaging in selected Canadian and U.S. markets.
News releases also cover Algernon’s ongoing pharmaceutical and neuroscience programs. This includes updates from Algernon NeuroScience, the company’s private subsidiary advancing a proprietary DMT program for stroke and traumatic brain injury, as well as intellectual property milestones for its chronic kidney disease candidate NP-251 (Repirinast). Additional coverage may address capital markets activity such as private placements, preferred share structures, and regulatory steps related to planned financings.
For readers tracking AGNPF, the news stream provides context on how Algernon is combining diagnostic imaging, clinic development, and drug research. Regularly reviewing these updates can help users understand changes in the company’s strategic focus, progress on clinic rollouts, developments in its neurological pipeline, and the evolution of its capital structure.
Algernon Pharmaceuticals has announced promising results from a preclinical study of its lead compound, NP-251 (Repirinast), which demonstrated a significant 56% reduction in fibrosis related to chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) in animal models. The study showed statistical significance in the results, with strong implications for Repirinast’s potential as an anti-fibrotic treatment across various diseases. The company plans to advance Repirinast into a Phase 1 clinical trial, supported by a well-established safety history in the Japanese market.
Algernon Pharmaceuticals announced a contract with Zhejiang Ausun Pharmaceutical to manufacture cGMP supply of its repurposed drug NP-251 (Repirinast). This drug, previously used for asthma in Japan, showed a 50% reduction in kidney fibrosis in preclinical trials. The company initiated a new CKD research program, aiming for human trials following a bridging toxicity study. Global CKD drug market expected to grow from $11.5 billion in 2015 to $15.8 billion by 2024. Algernon plans trials in Australia and the U.S., leveraging tax credits for research costs.
Algernon Pharmaceuticals has successfully completed enrollment in its Phase 2 study for NP-120 (Ifenprodil), targeting idiopathic pulmonary fibrosis (IPF) and chronic cough. This proof-of-concept trial includes 20 patients across 7 sites in Australia and New Zealand. Ifenprodil aims to assess the preservation of lung function and cough relief in IPF patients. A data readout is projected for Q2 2022. The drug has demonstrated anti-inflammatory properties and reduced cough frequency in preclinical models, positioning Algernon for potential advancements in IPF treatment.
Algernon Pharmaceuticals has received a Notice of Allowance for patent application No. 3101853 in Canada, covering methods for treating idiopathic pulmonary fibrosis (IPF) using Ifenprodil. The company has filed similar applications worldwide, including the U.S., Europe, China, and Japan. This marks a significant milestone in Algernon's drug repurposing strategy. Ifenprodil, an NMDA receptor antagonist, is currently being studied in a Phase 2 trial for its efficacy in preserving lung function in IPF patients. This progress reinforces Algernon's commitment to exploring new applications for existing drugs.
Algernon Pharmaceuticals has filed patent applications for novel salt forms of N,N-Dimethyltryptamine (DMT), enhancing its intellectual property portfolio. These novel salts aim to improve the drug's efficacy, safety, and stability. The company is also progressing in its planned Phase 1 DMT clinical human stroke study, having filed for regulatory approval in the UK. Previous studies suggest DMT may promote brain recovery following injury. Algernon focuses on repurposing safe, approved drugs to create new therapeutic applications.
Algernon Pharmaceuticals Inc. has submitted a combined Clinical Trials and Ethics Approval application to the UK Medicines and Healthcare Products Regulatory Agency for a Phase 1 study of AP-188 (DMT). This study aims to assess the safety, tolerability, and pharmacokinetics of DMT through prolonged intravenous infusion, involving 96 healthy volunteers. Positive feedback was previously received from the UK MHRA regarding the proposed DMT Stroke study. This research will inform future Phase 2 studies targeting acute stroke and rehabilitation patients.
Algernon Pharmaceuticals (CSE: AGN, OTCQB: AGNPF) announced positive feedback from the U.S. FDA regarding its pre-Investigational New Drug (pre-IND) meeting for NP-120 (Ifenprodil) targeting chronic cough treatment. The FDA provided guidance on the Phase 2b study protocol and requested genotoxicity testing, estimated to take 90 days. Interim data from a previous study indicated a trend toward reduced cough counts in patients. Ifenprodil demonstrated significant efficacy in preclinical studies, outperforming Merck's gefapixant in cough reduction.
Algernon Pharmaceuticals has expanded its clinical trial for NP-120 (Ifenprodil) in idiopathic pulmonary fibrosis (IPF) and chronic cough by adding a site in Perth, Australia. With seven sites now participating, the company aims for full enrollment by December 2021 and anticipates a data readout in Q2 2022. Positive interim data from the trial shows a trend of reduced cough counts after Ifenprodil treatment. The trial's objective is to evaluate Ifenprodil's efficacy in preserving lung function in IPF patients and assessing its anti-inflammatory effects.
Algernon Pharmaceuticals has appointed James Kinley as the new Chief Financial Officer (CFO), effective December 1, 2021. Kinley, a Certified Professional Accountant with over 15 years of experience, previously served as CFO for Medicure Inc. for nearly a decade. The CEO, Christopher J. Moreau, expressed confidence in Kinley’s expertise to help execute the company's ambitious business plan amid a growing pipeline of research programs. The company also acknowledged departing CFO Mike Sadhra for his contributions.
Algernon Pharmaceuticals has received favorable feedback from the U.S. FDA during its pre-IND meeting for NP-120 (Ifenprodil) aimed at treating small cell lung cancer (SCLC). The company plans to bypass additional pre-clinical research and will proceed with filing an IND application to initiate a Phase 1 clinical study. The FDA's guidance aids in protocol design for the study. Algernon intends to apply for orphan drug designation for Ifenprodil in SCLC treatment, aiming to expedite investigations into this potentially non-toxic cancer therapy.
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