Welcome to our dedicated page for Akari Therapeutics Plc news (Ticker: AKTX), a resource for investors and traders seeking the latest updates and insights on Akari Therapeutics Plc stock.
Akari Therapeutics plc (NASDAQ: AKTX) is an oncology biotechnology company whose news flow centers on the development of its PH1-based antibody–drug conjugates (ADCs). Company updates frequently highlight progress with its lead Trop2-targeting ADC, AKTX-101, and the broader PH1 spliceosome-modulating payload platform designed to disrupt RNA splicing in cancer cells and activate immune responses.
Investors following AKTX news can expect regular announcements on preclinical data, particularly in hard-to-treat solid tumors such as KRAS-mutant pancreatic ductal adenocarcinoma, urothelial (bladder) cancer, and gastric cancer. Akari’s releases often describe new efficacy and safety findings for AKTX-101, including comparisons with ADCs that use traditional payloads and exploratory work on synergy with checkpoint inhibitors.
Another recurring news theme is platform and pipeline development. Akari reports on the evolution of its ADC discovery platform, the advancement of additional candidates like AKTX-102 for GI and lung cancers, and scientific engagement through conference presentations and virtual investor segments such as its “CEO Corner” and “What This Means” features.
On the corporate side, Akari’s news includes financing transactions, such as registered direct offerings, private placements with warrants, and note exchanges that the company states are intended to fund research and development, working capital, and general corporate purposes. Updates on manufacturing partnerships, including GMP manufacturing of AKTX-101 with WuXi XDC, and disclosures related to Nasdaq listing requirements also appear in its news stream.
For readers tracking oncology innovation and early-stage ADC pipelines, the AKTX news page offers a focused view of how Akari is progressing its PH1 payload technology, preparing for potential clinical trials, and managing the capital and governance steps that support its development plans.
Akari Therapeutics announced promising results from a long-term study of nomacopan for patients with paroxysmal nocturnal hemoglobinuria (PNH). New data from 19 patients indicates that nomacopan is well-tolerated and has achieved a 79% transfusion independence rate among formerly transfusion-dependent patients treated for at least six months. The study demonstrated a significant reduction in monthly blood transfusions, with a 77% decline in unit requirements. These findings support nomacopan's potential for treating other complement dysregulation disorders, as noted by the company’s CEO.
Akari Therapeutics (Nasdaq: AKTX) announced findings from a two-year research collaboration with University College of London, highlighting the potential role of leukotriene B4 (LTB4) in retinal inflammation and degeneration. The study showed that the therapeutic administration of nomacopan effectively reduced retinal damage and inflammation in autoimmune uveitis models, rivaling the efficacy of standard steroid treatment, dexamethasone. Key findings reveal the decrease in Th17 cell and macrophage activity, indicating nomacopan's promise as a safer alternative to corticosteroids, which have significant side effects.
Akari Therapeutics has announced positive Phase II trial results for nomacopan, an experimental treatment for bullous pemphigoid (BP), a severe autoimmune disease. The FDA and EMA have approved progression to a Phase III randomized placebo-controlled study, which is set to begin in H1 2021. Nomacopan has received orphan drug designation in the U.S. and Europe. The upcoming poster presentation at the EADV Congress on October 29, 2020, will detail the safety and efficacy data. BP affects over 100,000 patients in the U.S. and Europe, with current treatments often resulting in severe side effects.
Akari Therapeutics (Nasdaq: AKTX) has received FDA clearance to proceed with a multi-center, double-blind randomized clinical study of its drug nomacopan for treating COVID-19 pneumonia in the U.S. and Brazil. This follows positive results from initial studies indicating effective use without up-dosing. The new study aims to evaluate the time to oxygen normalization and hospital discharge among over 120 patients, with treatment lasting up to 14 days. Nomacopan may address severe lung inflammation, a significant issue in COVID-19 pneumonia, by targeting multiple inflammatory pathways.
Akari Therapeutics (AKTX) announced its financial results for Q2 2020, reporting a net loss of approximately $8.3 million, up from $4.1 million in the prior year. The company has cash reserves of roughly $12.7 million, boosted by recent tax credits. Akari is advancing clinical programs for nomacopan, with a Phase III trial for bullous pemphigoid set for H1 2021 and enrollment for pediatric HSCT-TMA starting in Q4 2020. Notably, clinical trials for COVID-19 pneumonia are underway in multiple countries, leveraging nomacopan's dual-action mechanism.
Akari Therapeutics (Nasdaq: AKTX) is advancing nomacopan as a treatment for COVID-19 pneumonia through clinical trials in the U.S., U.K., and Brazil. The company has initiated proof of principle studies and aims to progress to randomized trials in Q4 2020. Nomacopan's dual action targeting both complement C5 and leukotriene B4 may reduce severe inflammation and improve outcomes for hospitalized patients. The AGILE initiative in the U.K. has chosen nomacopan for its trials, with data on approximately 50 patients expected soon, highlighting its potential efficacy.
Akari Therapeutics announces a pivotal Phase III trial for nomacopan in treating moderate to severe bullous pemphigoid (BP), following a successful EOP2 meeting with the FDA. The trial consists of two parts and aims for minimal oral corticosteroid use. Nomacopan has orphan drug designation in both the U.S. and Europe, with potential to replace long-term steroid treatments in vulnerable patients. The trial is set to begin in H1 2021, underscoring its significance in addressing a chronic condition lacking approved therapies.
Akari Therapeutics (NASDAQ: AKTX) has signed a Securities Purchase Agreement with Aspire Capital to raise up to $30 million through the sale of American Depositary Shares (ADSs). This follows a previous $9.3 million raise from Aspire in Q2 2020. The funds will support the development of nomacopan for conditions like bullous pemphigoid and COVID-19. The agreement allows Akari significant control over timing and amounts sold without any restrictive covenants. Additionally, Akari will issue 40,760,900 shares as a commitment fee to Aspire Capital.
Akari Therapeutics, Plc (NASDAQ: AKTX) has appointed Dr. Torsten Hombeck as Chief Financial Officer, enhancing its executive team. With over two decades of biopharmaceutical experience, Dr. Hombeck will oversee finance, investor relations, and business development from the New York office. His expertise in financial strategy and capital markets is expected to support Akari's growth, particularly in developing therapies for orphan autoimmune and inflammatory diseases. The company continues to focus on innovative treatments, notably nomacopan, a promising drug candidate.
Akari Therapeutics (Nasdaq: AKTX) announced a positive EMA opinion for orphan designation of nomacopan in treating bullous pemphigoid (BP). The Phase II study showed that 7 of 9 patients had significant reductions in BPDAI scores without serious adverse events. Nomacopan, a dual inhibitor of C5 and LTB4, has potential applications in treating COVID-19 pneumonia. The EMA's opinion may lead to market exclusivity and reduced regulatory fees within 30 days. CEO Clive Richardson emphasizes BP's therapeutic potential for nomacopan, also indicating broader applications for other inflammatory conditions.