Aligos Therapeutics Reports Recent Business Progress and Second Quarter 2026 Financial Results
Rhea-AI Summary
Aligos Therapeutics (Nasdaq: ALGS) reported second quarter 2026 results and pipeline updates, highlighting progress in its chronic hepatitis B (HBV) programs pevifoscorvir sodium and ALG-170675. Pevifoscorvir sodium received Breakthrough Therapy Designation in China in addition to prior U.S. Fast Track status, and the Phase 2 B-SUPREME study completed enrollment with 131 HBeAg+ and 114 HBeAg- participants. Topline data are expected in late Q3 2027.
According to Aligos, an exclusive Greater China license with Amoytop for pevifoscorvir sodium generated a $25M upfront payment and eligibility for up to $420M in milestones plus tiered high single-digit royalties, while Amoytop’s China IND approval for ALG-170675 triggered a $3M milestone. Q2 2026 net loss narrowed to $1.5M from $15.9M a year earlier, driven by $27.8M licensing revenue and warrant fair-value income, despite higher R&D expenses of $24.1M. Cash, cash equivalents and investments were $30.4M at June 30, 2026, excluding the $25M received in July, and are expected by the company to fund operations through Q4 2026.
Positive
- $25M upfront Greater China license payment for pevifoscorvir sodium
- Eligibility for up to $420M additional milestones plus tiered royalties
- Amoytop IND approval for ALG-170675 triggered $3M milestone to Aligos
- Q2 2026 net loss narrowed to $1.5M from $15.9M year over year
- Pevifoscorvir sodium gained Breakthrough Therapy Designation in China and has U.S. Fast Track
- Phase 2 B-SUPREME trial fully enrolled with 245 participants
Negative
- Quarter-end cash, cash equivalents and investments at $30.4M, funding expected only through Q4 2026
- Q2 2026 R&D expenses rose to $24.1M from $14.0M year over year
- Total operating expenses increased to $29.7M from $19.5M in Q2 2025
- Stockholders’ equity declined to $31.9M from $53.5M at year-end 2025
News Explained
Amoytop funds China development; Aligos keeps rights outside Greater China, while the triggered $3 million milestone remains due in Q3 2026.
For the China programs, Amoytop is funding current development costs, while Aligos retains rights outside Greater China and may use data generated by either partner in its respective territory.
Amoytop’s China IND approval for ALG-170675 has triggered a
Market reaction after 2Q26 earnings report: ALGS +9.92%
Following this news, ALGS has gained 9.92%, reflecting a notable positive market reaction. Our momentum scanner has triggered 12 alerts so far, indicating notable trading interest and price volatility. The stock is currently trading at $5.21.
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Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| May 07 | Q1 earnings report | Positive | +6.8% | Pipeline milestones and licensing economics accompanied the first-quarter financial results. |
| Mar 05 | Q4 earnings report | Neutral | -2.9% | Enrollment progress and cash runway were reported alongside full-year financial results. |
| Nov 06 | Q3 earnings report | Negative | -3.1% | Clinical progress was paired with funding considerations and quarterly losses. |
| Aug 06 | Q2 earnings report | Positive | +1.1% | Phase 2 progress and positive clinical data accompanied second-quarter financial results. |
| May 06 | Q1 earnings report | Positive | -9.3% | Capital raising and pipeline updates accompanied first-quarter financial results. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Tag-matched earnings reactions were mixed, with three aligned outcomes and two divergences.
Key Terms
antisense oligonucleotide medical
breakthrough therapy designation regulatory
ind approval regulatory
rnase h technical
hbeag medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
SOUTH SAN FRANCISCO, Calif., Aug. 06, 2026 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS, “Aligos”), a clinical stage biotechnology company focused on improving patient outcomes through best-in-class therapies for liver and viral diseases, today reported recent business progress and financial results for the second quarter 2026.
“Our team has continued to execute on our key strategic priorities to advance our pipeline this year,” stated Lawrence Blatt, Ph.D., M.B.A., Chairman, President, and Chief Executive Officer of Aligos Therapeutics. “We strengthened our financial position through non-dilutive capital, including the
Recent Business Progress
Pipeline Updates
Pevifoscorvir sodium: Potential first-/best-in-class small molecule CAM-E for chronic hepatitis B virus (HBV) infection
- In addition to Fast Track Designation from the U.S. Food and Drug Administration, pevifoscorvir sodium was granted Breakthrough Therapy Designation from the Center for Drug Evaluation (CDE) of China’s National Medical Products Administration (NMPA) for chronic hepatitis B virus (HBV) infection.
- The Phase 2 B-SUPREME study (NCT06963710) has completed enrollment with 131 participants enrolled in the HBeAg+ cohort (Part 1a) and 114 participants enrolled in the HBeAg- cohort (Part 2a).
- Topline data for both the HBeAg+ and HBeAg- cohorts are expected in late Q3 2027.
- The Company entered into an exclusive license deal with Xiamen Amoytop Biotech Co., Ltd. (Amoytop) to develop and commercialize pevifoscorvir sodium in Greater China for chronic HBV infection. Aligos received the
$25M upfront and is entitled to up to$420M USD in clinical, regulatory, and sales milestones with tiered, high single-digit royalties. - According to a recently published paper by Papatheodoridis, et. al. (Journal of Hepatology, July 2026), despite >10 years of nucleos(t)ide analog therapy, patients with chronic HBV infection remain at risk for hepatocellular carcinoma. Chronic HBV infection remains a large unmet medical need with ~240 million patients worldwide and 1.2 million new infections each year according to the World Health Organization.
ALG-170675: Potential best-in-class antisense oligonucleotide (ASO) for chronic hepatitis B virus (HBV) infection
- ALG-170675 is a next-generation ASO discovered as part of a research collaboration with Amoytop, who maintain rights in Greater China. Novel intellectual property has been filed for this candidate, which has shown improved RNase H mediated in vivo activity over GSK-836 (bepirovirsen) with similar hTLR8 agonist activity observed in vitro and in vivo. In addition, ALG-170675 utilizes novel monomers that could potentially reduce ASO toxicity and improve ASO liver to kidney ratios. Additionally, nonclinical studies have shown additive to synergistic effects when combined with a CAM-E.
- Our partner Amoytop received IND approval in China for ALG-170675, and is expected to advance the program into clinical studies with a Phase 1 SAD/MAD study in healthy volunteers, followed by multiple doses in participants with chronic HBV infection in China. Current costs for development in China are being funded by Amoytop, who maintain rights in Greater China.
- Amoytop’s receipt of IND approval in China for ALG-170675 triggered a
$3M milestone payment to Aligos, which is expected to be received in Q3 2026. - Under our agreement with Amoytop, Aligos retains ex-Greater China rights and all data generated by either partner can be used in their respective territories. Aligos has the potential to conduct a Phase 2 study in 2028, which may include combination therapy (e.g. pevifoscorvir sodium). Each party is responsible for their own development costs.
Financial Results for the Three Months Ended June 30, 2026
Cash, cash equivalents and investments totaled
Net loss for the three months ended June 30, 2026 was
Research and development (R&D) expenses for the three months ended June 30, 2026 were
General and administrative (G&A) expenses was flat at
Interest and other income, net, was income of
Change in fair value of 2023 common warrants for the three months ended June 30, 2026, was income of
About Aligos
Aligos Therapeutics, Inc. (NASDAQ: ALGS) is a clinical stage biotechnology company founded with the mission to improve patient outcomes by developing best-in-class therapies for the treatment of liver and viral diseases. Aligos applies its science driven approach and deep R&D expertise to advance its purpose-built pipeline of therapeutics for high unmet medical needs such as chronic hepatitis B virus (HBV) infection.
For more information, please visit www.aligos.com or follow us on LinkedIn or X.
Forward-Looking Statement
This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered “forward-looking statements,” including without limitation, statements with respect to the expected data releases and data presentations for the Company’s ASO program in HBV, and timing of data readouts for the pevifoscorvir sodium B-SUPREME study; potential success of the Company’s development programs, including timing of the Company’s anticipated ASO clinical trials; the potential for ALG-170675 to reduce ASO toxicity and improve ASO liver to kidney ratios; the potential additive to synergistic effects of ALG-170675 when combined with a CAM-E; statements about the Company’s plans to conduct a Phase 2 study on ALG-170675 in 2028, and whether it may include combination therapy (e.g. pevifoscorvir sodium); statements regarding potential financial milestones being met and future royalties being earned by Aligos under the Amoytop license, and regarding Amoytop’s success in developing the ASO and/or pevifoscorvir sodium in Greater China, including statements regarding timing and design of Amoytop’s anticipated clinical trials; and the company’s expectation that its cash, cash equivalents and investments provide sufficient funding of planned operations into the fourth quarter of 2026. Forward-looking statements are typically, but not always, identified by the use of words such as “may,” “will,” “would,” “believe,” “intend,” “plan,” “anticipate,” “estimate,” “expect,” and other similar terminology indicating future results. Such forward looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance, or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties inherent in the drug development process, including Aligos’ clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos’ ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos’ capital resources to fund operations, reliance on third parties for manufacturing and development efforts, reliance on collaborators to succeed in their development efforts and to comply with their contractual obligations, changes in the competitive landscape and the impact of global events and other macroeconomic conditions on Aligos’ business. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos’ Quarterly Report on Form 10-Q to be filed with the Securities and Exchange Commission on August 6, 2026 and Aligos’ Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 5, 2026 and its future periodic reports to be filed or submitted with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.
Investor Contact
Jordyn Tarazi
Vice President, Investor Relations & Corporate Communications
+1 (650) 910-0427
jtarazi@aligos.com
| Aligos Therapeutics, Inc | ||||||||||||
| Condensed Consolidated Statements of Operations | ||||||||||||
| (In thousands, except share and per share amounts) | ||||||||||||
| Three Months Ended | Six Months Ended | |||||||||||
| June 30, | June 30, | |||||||||||
| 2026 | 2025 | 2026 | 2025 | |||||||||
| Revenue from customers | $ | - | $ | 965 | $ | 2,830 | $ | 1,276 | ||||
| Revenue from licensing agreements | 27,778 | - | 27,778 | - | ||||||||
| Operating expenses: | ||||||||||||
| Research and development | 24,050 | 13,976 | 47,402 | 28,478 | ||||||||
| General and administrative | 5,618 | 5,556 | 12,025 | 10,608 | ||||||||
| Total operating expenses | 29,668 | 19,532 | 59,427 | 39,086 | ||||||||
| Loss from operations | (1,890 | ) | (18,567 | ) | (28,819 | ) | (37,810 | ) | ||||
| Interest and other income, net | 221 | 1,207 | 1,032 | 2,087 | ||||||||
| Change in fair value of 2023 common warrants | 2,976 | 1,682 | 6,371 | 63,176 | ||||||||
| Income (loss) before income tax | 1,307 | (15,678 | ) | (21,416 | ) | 27,453 | ||||||
| Income tax provision | (2,811 | ) | (185 | ) | (3,128 | ) | (228 | ) | ||||
| Net (loss) income | $ | (1,504 | ) | $ | (15,863 | ) | $ | (24,544 | ) | $ | 27,225 | |
| Net (loss) income per share, basic | $ | (0.14 | ) | $ | (1.53 | ) | $ | (2.36 | ) | $ | 2.90 | |
| Net (loss) income per share, diluted | $ | (0.14 | ) | $ | (1.53 | ) | $ | (2.36 | ) | $ | 2.90 | |
| Weighted-average shares of common stock, basic | 10,430,808 | 10,351,120 | 10,416,964 | 9,385,167 | ||||||||
| Weighted-average shares of common stock, diluted | 10,430,808 | 10,351,120 | 10,416,964 | 9,401,645 | ||||||||
| Aligos Therapeutics, Inc. Condensed Consolidated Balance Sheets (In thousands) | |||||
| June 30, 2026 | December 31, 2025 | ||||
| (Unaudited) | (Audited)(1) | ||||
| Assets | |||||
| Current assets: | |||||
| Cash and cash equivalents | $ | 30,381 | $ | 18,303 | |
| Short-term investments | - | 59,541 | |||
| Accounts receivable | 27,778 | - | |||
| Other current assets | 3,968 | 5,018 | |||
| Total current assets | 62,127 | 82,862 | |||
| Other assets | 4,200 | 5,671 | |||
| Total assets | $ | 66,327 | $ | 88,533 | |
| Liabilities and Stockholders’ Equity | |||||
| Current liabilities | $ | 28,343 | $ | 21,233 | |
| Other liabilities, noncurrent | 6,100 | 13,755 | |||
| Total liabilities | 34,443 | 34,988 | |||
| Total stockholders’ equity | 31,884 | 53,545 | |||
| Total liabilities and stockholders’ equity | $ | 66,327 | $ | 88,533 | |
_____________________________________________
(1) The condensed consolidated balance sheet as of December 31, 2025 has been derived from the audited consolidated financial statements at that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025.
