Welcome to our dedicated page for Alnylam Pharmaceuticals news (Ticker: ALNY), a resource for investors and traders seeking the latest updates and insights on Alnylam Pharmaceuticals stock.
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY) regularly issues news on its RNA interference (RNAi) therapeutics, commercial performance, pipeline progress, and corporate developments. As a company that has led the RNAi field from discovery to approved medicines, its announcements often highlight data from pivotal trials, regulatory milestones, and updates on marketed products such as AMVUTTRA, ONPATTRO, GIVLAARI, and OXLUMO.
Investors following ALNY news can expect detailed coverage of clinical results across multiple therapeutic areas, including transthyretin‑mediated amyloidosis (ATTR), hypertension, bleeding disorders, neurological diseases, and metabolic conditions. Recent releases have described post hoc analyses from the HELIOS‑B Phase 3 study of AMVUTTRA in ATTR‑CM and hATTR‑PN, showing effects on gastrointestinal events, cardiac structure and function, and renal outcomes, as well as broader safety and efficacy profiles.
Alnylam’s news flow also includes financial and strategic updates. The company reports quarterly and annual net product revenues, trends in its TTR and rare disease franchises, and guidance associated with frameworks such as its Alnylam P5x25 and Alnylam 2030 strategies. Filings and press releases have discussed convertible senior notes, a revolving credit facility, and partial repurchases of outstanding debt, providing context on capital structure and liquidity.
Operational and manufacturing developments are another key news theme. Alnylam has announced expansion of its Norton, Massachusetts siRNA manufacturing facility and the integration of its siRELIS enzymatic ligation platform, which has been accepted into the FDA’s Emerging Technology Program. Corporate governance items, such as changes to the Board of Directors and executive responsibilities, are also disclosed. For anyone tracking ALNY, this news stream offers insight into clinical milestones, commercial execution, manufacturing scale‑up, and strategic direction in RNAi therapeutics.
Alnylam Pharmaceuticals (Nasdaq: ALNY) will present an overview and participate in a Q&A session at the 41st Annual J.P. Morgan Healthcare Conference on January 9, 2023, at 9:45 am PT (12:45 pm ET) in San Francisco. The presentation will include an update on unaudited global net product revenues for Q4 and full year 2022. A live audio webcast will be available on their website, with a replay accessible within 48 hours. Alnylam is known for pioneering RNA interference therapeutics aimed at treating rare diseases.
Alnylam Pharmaceuticals (ALNY) has submitted a Clinical Trial Authorization application to Health Canada to initiate a Phase 1/2 study of ALN-KHK, an investigational RNAi therapeutic for Type 2 diabetes mellitus (T2DM). The study is set to enroll healthy and obese patients in early 2023, with initial results expected by late 2023. ALN-KHK targets ketohexokinase to potentially improve glycemic control. With T2DM affecting over 450 million globally, the need for effective treatments remains critical. Alnylam aims to innovate in the RNAi therapeutic space, leveraging new technologies.
Alnylam Pharmaceuticals hosted its R&D Day, outlining goals for 2023, including a potential label expansion and plans to report ten clinical datasets from its RNAi platform. The company aims for strong commercial execution across four brands and anticipates FDA approval for Patisiran to treat cardiomyopathy associated with ATTR amyloidosis in late 2023. Alnylam also plans to advance investigational therapies for various conditions including hypertension, Alzheimer's, and Type 2 diabetes. The webcast of the event is available online.
Alnylam Pharmaceuticals has submitted a supplemental New Drug Application (sNDA) to the FDA for patisiran, an investigational RNAi therapeutic aimed at treating transthyretin-mediated (ATTR) amyloidosis with cardiomyopathy. This follows positive results from the Phase 3 APOLLO-B study, which demonstrated significant improvements in functional capacity and quality of life at 12 months. The study also showed an encouraging safety profile, with most adverse events being mild to moderate. Patisiran is already FDA approved for polyneuropathy of hereditary ATTR amyloidosis.
Alnylam Pharmaceuticals has announced a virtual R&D Day scheduled for December 15, 2022, at 8:30 am ET, which will be webcast on the company's website. A replay will be available within 48 hours post-event. Alnylam, a leader in RNA interference therapeutics, aims to transform treatments for rare and common diseases. The company has developed several commercial products and has a robust pipeline of investigational medicines. To learn more, visit www.alnylam.com.
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Alnylam Pharmaceuticals (Nasdaq: ALNY) has announced its participation in multiple healthcare conferences. On November 16, 2022, the company will present at both the Jefferies London Healthcare Conference and Stifel 2022 Healthcare Conference at 2:05 pm GMT and 1:15 pm ET, respectively. Additionally, Alnylam will engage in the Evercore ISI HealthCONx Conference on November 29, and the Piper Sandler Healthcare Conference on November 30. A live audio webcast of these events will be available on Alnylam's website.
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Alnylam Pharmaceuticals reported Q3 2022 global net product revenues of $232 million, a 39% increase year-over-year. AMVUTTRA achieved $25 million in revenue, driving a 30% increase in U.S. TTR growth from Q2. Positive results were announced from the APOLLO-B Phase 3 study of patisiran, with an sNDA submission planned by year-end. The company reiterated its 2022 combined net product revenue guidance of $870-$930 million. Research and development expenses rose, while cash and equivalents were $2.27 billion as of September 30, down from $2.44 billion at the year's start.
Alnylam Pharmaceuticals (NASDAQ: ALNY) will report its third-quarter financial results on October 27, 2022, before U.S. market opening. The management will hold a conference call on the same date at 8:30 am ET to discuss the results and future expectations. A live audio webcast will be available on the company's investor website. Alnylam continues to lead in RNA interference therapeutics, offering products like ONPATTRO and GIVLAARI, and has a robust pipeline with six late-stage candidates. The firm is committed to developing innovative medicines for rare diseases.