Altimmune Announces Second Quarter 2025 Financial Results and Business Update
Altimmune (NASDAQ:ALT) announced positive results from its IMPACT Phase 2b trial for pemvidutide in MASH treatment. The drug achieved statistically significant MASH resolution in up to 59.1% of patients and demonstrated fibrosis improvement in up to 34.5% of treated patients. New data showed potentially class-leading improvements in corrected T1 (cT1) imaging, with significant decreases of 145.0ms and 147.9ms in the 1.2mg and 1.8mg groups respectively.
The company reported $183.1 million in cash and investments as of June 30, 2025, a 39% increase from December 31, 2024. Altimmune initiated two new Phase 2 trials: RECLAIM for Alcohol Use Disorder and RESTORE for Alcohol-Associated Liver Disease. An End-of-Phase 2 Meeting with FDA is expected in Q4 2025, with full 48-week IMPACT trial data also anticipated in the same quarter.
Altimmune (NASDAQ:ALT) ha annunciato risultati positivi dal suo trial IMPACT di fase 2b su pemvidutide nel trattamento della MASH. Il farmaco ha ottenuto una risoluzione della MASH statisticamente significativa in fino al 59,1% dei pazienti e ha mostrato un miglioramento della fibrosi in fino al 34,5% dei soggetti trattati. Nuovi dati hanno evidenziato miglioramenti potenzialmente ai vertici della categoria nella imaging corrected T1 (cT1), con riduzioni significative di 145,0 ms e 147,9 ms nei gruppi da 1,2 mg e 1,8 mg rispettivamente.
L'azienda ha dichiarato di avere 183,1 milioni di dollari in contanti e investimenti al 30 giugno 2025, con un aumento del 39% rispetto al 31 dicembre 2024. Altimmune ha avviato due nuovi studi di Fase 2: RECLAIM per il Disturbo da Uso di Alcol e RESTORE per le Malattie Epatiche Associate all'Alcol. Un incontro di fine Fase 2 con la FDA è previsto nel quarto trimestre 2025, e nello stesso periodo sono attesi i dati completi a 48 settimane dello studio IMPACT.
Altimmune (NASDAQ:ALT) anunció resultados positivos de su ensayo IMPACT de fase 2b con pemvidutide en el tratamiento de MASH. El fármaco logró una resolución de MASH estadísticamente significativa en hasta el 59,1% de los pacientes y mostró mejora de la fibrosis en hasta el 34,5% de los pacientes tratados. Nuevos datos revelaron mejoras potencialmente líderes en su clase en la imagen corrected T1 (cT1), con disminuciones significativas de 145,0 ms y 147,9 ms en los grupos de 1,2 mg y 1,8 mg, respectivamente.
La compañía informó tener 183,1 millones de dólares en efectivo e inversiones al 30 de junio de 2025, un aumento del 39% respecto al 31 de diciembre de 2024. Altimmune inició dos nuevos ensayos de Fase 2: RECLAIM para el Trastorno por Consumo de Alcohol y RESTORE para la Enfermedad Hepática Asociada al Alcohol. Se espera una reunión de fin de Fase 2 con la FDA en el cuarto trimestre de 2025, y también se prevén los datos completos de 48 semanas del ensayo IMPACT en ese mismo trimestre.
Altimmune (NASDAQ:ALT)는 MASH 치료를 위한 pemvidutide의 IMPACT 2b상 시험에서 긍정적인 결과를 발표했습니다. 해당 약물은 환자의 최대 59.1%에서 통계적으로 유의한 MASH 완화를 달성했으며, 치료군의 최대 34.5%에서 섬유화 개선을 보였습니다. 새로운 데이터는 보정된 T1(cT1) 영상에서 계열을 선도할 가능성이 있는 개선을 시사했으며, 1.2mg 및 1.8mg군에서 각각 145.0ms와 147.9ms의 유의한 감소가 관찰되었습니다.
회사는 2025년 6월 30일 기준으로 현금 및 투자 자산 1억 8,310만 달러를 보유하고 있다고 보고했으며, 이는 2024년 12월 31일 대비 39% 증가한 수치입니다. Altimmune는 알코올 사용 장애를 대상으로 하는 RECLAIM과 알코올 관련 간질환을 위한 RESTORE 등 두 건의 신규 2상 시험을 시작했습니다. FDA와의 End-of-Phase 2 미팅은 2025년 4분기로 예정되어 있으며, 같은 분기에 48주 전체 IMPACT 시험 데이터도 발표될 것으로 예상됩니다.
Altimmune (NASDAQ:ALT) a annoncé des résultats positifs de son essai IMPACT de phase 2b sur le pemvidutide pour le traitement de la MASH. Le médicament a obtenu une résolution de la MASH statistiquement significative chez jusqu'à 59,1 % des patients et a montré une amélioration de la fibrose chez jusqu'à 34,5 % des patients traités. De nouvelles données ont révélé des améliorations potentiellement de premier plan pour la classe sur l'imagerie corrected T1 (cT1), avec des diminutions significatives de 145,0 ms et 147,9 ms dans les groupes 1,2 mg et 1,8 mg, respectivement.
L'entreprise a déclaré disposer de 183,1 millions de dollars en liquidités et investissements au 30 juin 2025, soit une hausse de 39 % par rapport au 31 décembre 2024. Altimmune a lancé deux nouveaux essais de phase 2 : RECLAIM pour le trouble lié à l'usage d'alcool et RESTORE pour les maladies hépatiques associées à l'alcool. Une réunion de fin de phase 2 avec la FDA est prévue au quatrième trimestre 2025, et les données complètes à 48 semaines de l'essai IMPACT sont également attendues au cours de ce trimestre.
Altimmune (NASDAQ:ALT) meldete positive Ergebnisse aus der IMPACT Phase-2b-Studie mit Pemvidutide zur Behandlung von MASH. Das Medikament erzielte eine statistisch signifikante MASH-Heilung bei bis zu 59,1 % der Patienten und zeigte eine Verbesserung der Fibrose bei bis zu 34,5 % der Behandelten. Neue Daten zeigten potenziell klassenführende Verbesserungen im corrected T1 (cT1)-Imaging, mit signifikanten Verringerungen um 145,0 ms bzw. 147,9 ms in den 1,2 mg- und 1,8 mg-Gruppen.
Das Unternehmen berichtete über 183,1 Millionen US-Dollar an Barmitteln und Investitionen zum 30. Juni 2025, ein Anstieg von 39 % gegenüber dem 31. Dezember 2024. Altimmune hat zwei neue Phase-2-Studien initiiert: RECLAIM für Alkoholgebrauchsstörung und RESTORE für alkoholbedingte Lebererkrankungen. Ein End-of-Phase-2-Meeting mit der FDA wird für das vierte Quartal 2025 erwartet, wobei die vollständigen 48-Wochen-Daten der IMPACT-Studie ebenfalls in diesem Quartal erwartet werden.
- Significant MASH resolution achieved in up to 59.1% of pemvidutide-treated patients
- Strong safety profile with less than 1% treatment discontinuations due to adverse events
- Potentially class-leading improvements in cT1 imaging results
- Robust cash position of $183.1M, representing 39% increase from December 2024
- Pipeline expansion with two new Phase 2 trials in AUD and ALD
- Net loss of $22.1 million in Q2 2025
- Research and development expenses of $17.2 million for the quarter
Insights
Pemvidutide shows impressive MASH resolution and weight loss data, positioning Altimmune strongly ahead of End-of-Phase 2 FDA meeting.
Altimmune's pemvidutide data represents a potentially groundbreaking development in MASH therapeutics. The reported 59.1% MASH resolution rate without worsening of fibrosis is remarkable in this difficult-to-treat condition where few effective options exist. For context, this far exceeds typical response rates seen in competitive MASH trials, which often struggle to achieve even 30% resolution rates.
The new corrected T1 (cT1) imaging data is particularly compelling. The ~145-148ms reductions in cT1 relaxation time far surpass the clinically meaningful threshold of 80ms and dwarf the placebo response of 27.5ms. These substantial improvements strongly predict positive histological outcomes, as cT1 serves as a reliable surrogate for inflammation and fibrosis reduction.
The dual benefit of 6.2% weight loss coupled with MASH resolution creates a differentiated profile. Notably, pemvidutide achieved this without requiring dose titration while maintaining an exceptional safety profile with fewer adverse event discontinuations than placebo and <1% treatment discontinuations. This tolerability profile distinguishes it from other GLP-1 based therapies that often require gradual dose escalation and have higher discontinuation rates.
Altimmune's expansion into alcohol-related conditions (AUD and ALD) through the RECLAIM and RESTORE trials represents intelligent pipeline leverage, targeting significant unmet needs with mechanistic rationale. These programs could unlock substantial additional market potential beyond MASH.
With $183.1 million cash (up 39% from December), Altimmune appears well-positioned to advance toward pivotal trials following their upcoming End-of-Phase 2 FDA meeting. This financial position likely provides runway through significant upcoming milestones, including the full 48-week IMPACT data expected in Q4 2025.
Strong clinical data and $183.1M cash position strengthen Altimmune's competitive position in the lucrative MASH market.
Altimmune's financial position has significantly strengthened with $183.1 million in cash and investments, representing a robust 39% increase from December 2024. This capital infusion provides crucial runway for pemvidutide's Phase 3 development in MASH following their upcoming FDA meeting, while simultaneously supporting expansion into alcohol-related indications.
The company has demonstrated efficient capital deployment with R&D expenses decreasing to $17.2 million from $21.2 million year-over-year, while maintaining stable G&A expenses at approximately $5.7 million. This discipline has helped reduce quarterly net losses to $22.1 million ($0.27/share) from $24.6 million ($0.35/share) in the comparable period.
The pemvidutide data positions Altimmune competitively in the emerging MASH therapeutics landscape. The superior safety profile with <1% treatment discontinuations could translate to significant commercial advantage against competitors with more challenging tolerability profiles. The dual action of liver disease resolution coupled with weight loss addresses two key market needs simultaneously.
The expansion into alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) represents strategic portfolio diversification. These conditions affect millions globally with limited treatment options, potentially creating multiple revenue streams from a single asset.
The appointment of Jerry Durso as Chairman signals preparation for commercialization, leveraging his extensive commercial expertise as Altimmune transitions from clinical development toward potential market entry. This leadership change, aligned with advancing pemvidutide to Phase 3, indicates confidence in their clinical program and focus on building commercial infrastructure ahead of potential approval.
Positive data from the IMPACT Phase 2b trial reinforces the potential for pemvidutide to be a highly differentiated MASH therapy
Pemvidutide is the first product candidate to achieve statistically significant MASH resolution and weight loss at 24 weeks
New data from the IMPACT trial demonstrates potentially class-leading improvements in corrected T1 (cT1), an important marker of liver inflammation and fibrosis
End-of-Phase 2 Meeting with FDA expected in Q4 2025
Cash, cash equivalents and short-term investments of
Webcast to be held today, August 12, 2025, at 8:30 a.m. ET
GAITHERSBURG, Md., Aug. 12, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing peptide-based therapeutics for liver and cardiometabolic diseases, today announced financial results for the second quarter ended June 30, 2025 and provided a business update.
“Pemvidutide demonstrated rapid and robust MASH effects, meaningful weight loss and impressive safety and tolerability in the recently reported results from the IMPACT Phase 2b trial,” said Vipin K. Garg, Ph.D., President and Chief Executive Officer of Altimmune. “We are preparing for an End-of-Phase 2 Meeting with the FDA which will position us well for Phase 3 development. In addition, we look forward to reporting the full 48-week data in the fourth quarter and providing further updates as we continue to advance pemvidutide.”
Dr. Scott Harris, Chief Medical Officer of Altimmune, commented, “The improvements in cT1 observed in the IMPACT trial were potentially class-leading among MASH clinical trials to-date. Reductions in cT1 are correlated with MASH resolution and fibrosis improvement. These new data along with the previously reported results from non-invasive tests of fibrosis, further strengthen the potential therapeutic value of pemvidutide.”
Recent Highlights and Anticipated Milestones
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
- Reported positive 24-week top-line data from the IMPACT Phase 2b trial
- Statistically significant MASH resolution without worsening of fibrosis was observed in up to
59.1% of patients receiving pemvidutide - Fibrosis improvement without worsening of MASH was observed in up to
34.5% of pemvidutide-treated patients - Statistically significant improvements were observed across multiple objective measures of fibrosis, including supplemental AI-based analyses and non-invasive tests (NITs) of liver fibrosis, Enhanced Liver Fibrosis (ELF) score and Vibration-Controlled Transient Elastography (VCTE)
- Statistically significant weight loss of up to
6.2% at 24 weeks with a trajectory of continuing weight loss - Potential for best-in-class tolerability without dose titration
- Fewer adverse event-related discontinuations with pemvidutide vs placebo
- Less than
1% treatment discontinuations due to adverse events in pemvidutide-treated patients
- Statistically significant MASH resolution without worsening of fibrosis was observed in up to
- New data on corrected T1 (cT1) imaging demonstrates potentially class-leading improvements in pemvidutide-treated patients
- cT1 is a highly reproducible MRI-based imaging method that measures the magnitude of liver inflammation and fibrosis. Decreases in cT1 relaxation time of 80 milliseconds (ms) or greater have been correlated with improvements in liver inflammation and fibrosis in clinical studies.
- In an analysis of imaging data from the IMPACT trial, mean decreases from baseline in cT1 relaxation time were 145.0 ms and 147.9 ms in the pemvidutide 1.2 mg and 1.8 mg groups, respectively, compared with a decrease of 27.5 ms in placebo (p < 0.001 for both)
- The IMPACT trial is ongoing with data on weight loss, NITs and safety at 48 weeks of treatment expected in the fourth quarter of 2025
- End-of-Phase 2 Meeting with FDA targeted for fourth quarter of 2025
Alcohol Use Disorder (AUD)
- Announced in May 2025 the initiation of RECLAIM, a Phase 2 trial evaluating the safety and efficacy of pemvidutide in AUD
- RECLAIM is a randomized, placebo-controlled trial expected to enroll approximately 100 subjects, randomized 1:1, to receive either 2.4 mg pemvidutide or placebo weekly for 24 weeks
- The primary endpoint of the trial is the change from baseline in the average number of heavy drinking days per week at 24 weeks
- Key secondary endpoints include the proportion of subjects achieving a 2-level reduction in World Health Organization (WHO) risk drinking level and absolute change from baseline in average levels of phosphatidylethanol (PEth) a serum biomarker of alcohol intake
Alcohol-Associated Liver Disease (ALD)
- Announced in July 2025 the initiation of RESTORE, a Phase 2 trial evaluating the safety and efficacy of pemvidutide in ALD
- RESTORE is a randomized, placebo-controlled trial expected to enroll approximately 100 subjects, randomized 1:1 to receive either 2.4 mg pemvidutide or placebo weekly for 48 weeks
- The primary endpoint of the trial is the change from baseline in liver stiffness measurement (LSM), as measured by VCTE, at week 24
- Key secondary endpoints include the change from baseline in LSM at week 48, changes in ELF score at weeks 24 and 48, and changes in alcohol consumption and body weight at both 24 and 48 weeks
Corporate Update
- Jerry Durso appointed by Altimmune Board of Directors to succeed Mitchel Sayare, Ph.D. as Chairman
- Appointment is part of the Board’s ongoing succession planning. It recognizes Mr. Durso’s extensive commercial and corporate development expertise and aligns with Altimmune’s planned advancement into Phase 3 development of pemvidutide in MASH.
- Dr. Sayare to continue to serve on the Board as an Independent Director
Financial Results for the Three Months Ended June 30, 2025
- Altimmune reported cash, cash equivalents and short-term investments totaling
$183.1 million as of June 30, 2025, a39% increase as compared to$131.9 million at December 31, 2024 - Research and development expenses were
$17.2 million for the three months ended June 30, 2025, compared to$21.2 million in the same period in 2024, the decrease resulting from timing of clinical trial costs. The expenses for the quarter ended June 30, 2025, included$11.2 million in direct costs related to pemvidutide development activities - General and administrative expenses were consistent period-over-period at
$5.7 million and$5.6 million for the three months ended June 30, 2025 and 2024, respectively - Interest income was
$1.1 million for the three months ended June 30, 2025 - Net loss for the three months ended June 30, 2025, was
$22.1 million , or$0.27 net loss per share, compared to a net loss of$24.6 million , or$0.35 net loss per share, in the same period in 2024
Conference Call Information: | |
Date: | August 12, 2025 |
Time: | 8:30 a.m. Eastern Time |
Webcast: | To listen, the conference call will be webcast live on Altimmune’s Investor Relations website at https://ir.altimmune.com/investors. |
Dial-in: | To participate or dial-in, register here to receive the dial-in numbers and unique PIN to access the call. |
Following the conclusion of the call, the webcast will be available for replay on the Investor Relations (IR) page of the Company’s website at www.altimmune.com. The Company has used, and intends to continue to use, the IR portion of its website as a means of disclosing material non-public information and for complying with disclosure obligations under Regulation FD.
About Pemvidutide
Pemvidutide is a novel, investigational, peptide-based 1:1 GLP-1/glucagon dual receptor agonist in development for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH), Alcohol Use Disorder (AUD), Alcohol-Associated Liver Disease (ALD) and obesity. Activation of the GLP-1 and glucagon receptors is believed to mimic the complementary effects of diet and exercise on weight loss, with GLP-1 suppressing appetite and glucagon increasing energy expenditure. Glucagon is also recognized as having direct effects on hepatic fat metabolism, which is believed to lead to rapid reductions in levels of liver fat and serum lipids. In the ongoing IMPACT Phase 2b trial, at Week 24, once-weekly pemvidutide demonstrated statistically significant MASH resolution without worsening of fibrosis, positive trends in liver fibrosis stage improvement without worsening of MASH, statistically significant reductions in non-invasive tests of fibrosis, weight loss, and liver fat content, and improvements in blood pressure. In a post-hoc AI-based analysis of the biopsies from the IMPACT trial, pemvidutide achieved a statistically significant reduction in liver fibrosis. In earlier trials, pemvidutide also demonstrated class-leading lean mass preservation and robust reductions in triglycerides and LDL cholesterol. Pemvidutide was well tolerated in the IMPACT trial, demonstrating potentially best-in-class tolerability among drugs in development for MASH with very low rates of discontinuation due to adverse events. The U.S. FDA granted Fast Track designation to pemvidutide for the treatment of MASH. The ongoing IMPACT Phase 2b MASH trial 48-week readout is expected in Q4 2025. In addition, RECLAIM, a Phase 2 trial in AUD and RESTORE, a Phase 2 trial in ALD, were initiated in May 2025 and July 2025, respectively.
About Altimmune
Altimmune is a late clinical-stage biopharmaceutical company focused on developing novel peptide-based therapeutics for liver and cardiometabolic diseases. The Company’s lead program is pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of MASH, Alcohol Use Disorder (AUD), Alcohol-Associated Liver Disease (ALD) and obesity. For more information, please visit www.altimmune.com.
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Forward-Looking Statement
Any statements made in this press release related to the development or commercialization of pemvidutide, an investigational product candidate, and other business and financial matters including without limitation, clinical trial study design, status, correspondence, results and data, including the ongoing RECLAIM, RESTORE and IMPACT Trials, the timing of key milestones for the Company’s clinical assets, future plans or expectations for pemvidutide for the treatment of MASH, AUD, ALD and obesity, and the prospects for receiving regulatory approval or commercializing or selling any product or drug candidates, and the impact of the changes to our leadership and governance structure, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words "may," "could," "should," "anticipate," "believe," "estimate," "expect," "intend," "plan," "predict" and similar expressions and their variants, as they relate to Altimmune, Inc. may identify forward-looking statements. The Company cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward-looking statements or historical experience include risks and uncertainties, including risks relating to: delays in regulatory review, manufacturing and supply chain interruptions, access to clinical sites, enrollment, adverse effects on healthcare systems and disruption of the global economy; the reliability of the results of studies relating to human safety and possible adverse effects resulting from the administration of the Company's product candidates; the Company's ability to manufacture clinical trial materials on the timelines anticipated; and the success of future product advancements, including the success of future clinical trials. Further information on the factors and risks that could affect the Company's business, financial conditions and results of operations are contained in the Company's filings with the U.S. Securities and Exchange Commission, including under the heading "Risk Factors" in the Company's most recent annual report on Form 10-K, quarterly report on Form 10-Q and the Company’s other filings with the SEC, which are available at www.sec.gov.
Company Contact:
Greg Weaver
Chief Financial Officer
Phone: 240-654-1450
ir@altimmune.com
Investor Contact:
Lee Roth
Burns McClellan
Phone: 646-382-3403
lroth@burnsmc.com
Media Contact:
Jake Robison
Inizio Evoke Comms
Phone: 619-849-5383
jake.robison@inizioevoke.com
ALTIMMUNE, INC. CONSOLIDATED BALANCE SHEETS (In thousands, except share and per-share amounts) | ||||||||
June 30, | December 31, | |||||||
2025 | 2024 | |||||||
(Unaudited) | ||||||||
ASSETS | ||||||||
Current assets: | ||||||||
Cash and cash equivalents | $ | 183,105 | $ | 36,926 | ||||
Restricted cash | 42 | 42 | ||||||
Total cash, cash equivalents and restricted cash | 183,147 | 36,968 | ||||||
Short-term investments | — | 94,965 | ||||||
Accounts and other receivables | 321 | 544 | ||||||
Income tax and R&D incentive receivables | 557 | 2,573 | ||||||
Prepaid expenses and other current assets | 4,397 | 2,204 | ||||||
Total current assets | 188,422 | 137,254 | ||||||
Property and equipment, net | 364 | 413 | ||||||
Other assets | 1,564 | 1,639 | ||||||
Total assets | $ | 190,350 | $ | 139,306 | ||||
LIABILITIES AND STOCKHOLDERS’ EQUITY | ||||||||
Current liabilities: | ||||||||
Accounts payable | $ | 851 | $ | 211 | ||||
Accrued expenses and other current liabilities | 8,369 | 10,257 | ||||||
Total current liabilities | 9,220 | 10,468 | ||||||
Term loan, noncurrent | 14,332 | — | ||||||
Other noncurrent liabilities | 5,431 | 5,330 | ||||||
Total liabilities | 28,983 | 15,798 | ||||||
Commitments and contingencies | ||||||||
Stockholders’ equity: | ||||||||
Stockholders’ equity: | 9 | 7 | ||||||
Additional paid-in capital | 769,508 | 689,864 | ||||||
Accumulated deficit | (603,111 | ) | (561,390 | ) | ||||
Accumulated other comprehensive loss, net | (5,039 | ) | (4,973 | ) | ||||
Total stockholders’ equity | 161,367 | 123,508 | ||||||
Total liabilities and stockholders’ equity | $ | 190,350 | $ | 139,306 |
ALTIMMUNE, INC. CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited) (In thousands, except share and per-share amounts) | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2025 | 2024 | 2025 | 2024 | |||||||||||||
Revenues | $ | 5 | $ | 5 | $ | 10 | $ | 10 | ||||||||
Operating expenses: | ||||||||||||||||
Research and development | 17,236 | 21,155 | 33,063 | 42,642 | ||||||||||||
General and administrative | 5,691 | 5,595 | 11,684 | 10,907 | ||||||||||||
Total operating expenses | 22,927 | 26,750 | 44,747 | 53,549 | ||||||||||||
Loss from operations | (22,922 | ) | (26,745 | ) | (44,737 | ) | (53,539 | ) | ||||||||
Other income (expense): | ||||||||||||||||
Interest expense | (264 | ) | (1 | ) | (265 | ) | (2 | ) | ||||||||
Interest income | 1,132 | 2,182 | 2,677 | 4,595 | ||||||||||||
Other income (expense), net | (92 | ) | (76 | ) | (77 | ) | (88 | ) | ||||||||
Total other income (expense), net | 776 | 2,105 | 2,335 | 4,505 | ||||||||||||
Net loss before income taxes | (22,146 | ) | (24,640 | ) | (42,402 | ) | (49,034 | ) | ||||||||
Income tax expense (benefit) | — | — | (681 | ) | — | |||||||||||
Net loss | (22,146 | ) | (24,640 | ) | (41,721 | ) | (49,034 | ) | ||||||||
Other comprehensive income — unrealized loss on short-term investments | (36 | ) | (31 | ) | (66 | ) | (188 | ) | ||||||||
Comprehensive loss | $ | (22,182 | ) | $ | (24,671 | ) | $ | (41,787 | ) | $ | (49,222 | ) | ||||
Net loss per share, basic and diluted | $ | (0.27 | ) | $ | (0.35 | ) | $ | (0.53 | ) | $ | (0.69 | ) | ||||
Weighted-average common shares outstanding, basic and diluted | 81,477,548 | 70,924,371 | 78,529,028 | 70,863,042 |
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