Welcome to our dedicated page for Altimmune news (Ticker: ALT), a resource for investors and traders seeking the latest updates and insights on Altimmune stock.
Altimmune, Inc. (Nasdaq: ALT) generates a steady flow of news as a late clinical-stage biopharmaceutical company developing peptide-based therapeutics for liver, metabolic and cardiometabolic diseases. Most company updates center on its lead investigational medicine, pemvidutide, a balanced 1:1 glucagon/GLP-1 dual receptor agonist in development for metabolic dysfunction-associated steatohepatitis (MASH), alcohol use disorder (AUD), alcohol-associated liver disease (ALD) and obesity.
News coverage of ALT frequently highlights clinical trial milestones. Altimmune issues detailed press releases on the IMPACT Phase 2b trial in MASH, including 24-week and 48-week topline data, changes in non-invasive tests of fibrosis and hepatic inflammation, and AI-based digital pathology analyses of liver biopsies. Additional updates describe progress in the RECLAIM Phase 2 trial in AUD and the RESTORE Phase 2 trial in ALD, including enrollment status and expected timelines for topline results.
Investors and followers of ALT stock also see regulatory and scientific news, such as Fast Track designations for pemvidutide in MASH and AUD, Breakthrough Therapy Designation for MASH, and publication of IMPACT trial data in peer-reviewed journals. Presentations at major medical meetings, including late-breaking oral and poster sessions at The Liver Meeting hosted by the American Association for the Study of Liver Diseases (AASLD), are common subjects of company announcements.
Altimmune’s news flow further includes corporate and financial updates. These range from quarterly financial results and business updates to CEO succession plans, executive appointments, term loan amendments and at-the-market equity offering arrangements disclosed in SEC filings and companion press releases. For anyone tracking ALT, this news page brings together clinical, regulatory, scientific and corporate developments in one place, making it easier to follow how Altimmune’s programs and capital strategy evolve over time.
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Altimmune, Inc. (Nasdaq: ALT) has successfully completed enrollment in its Phase 2 clinical trial of HepTcell, an immunotherapeutic targeting chronic hepatitis B (CHB). This trial involves approximately 80 subjects across 26 sites in North America, Europe, and Southeast Asia. The primary endpoint is a significant reduction in hepatitis B surface antigen (HBsAg). The data readout is anticipated in Q1 2024. HepTcell, which combines nine synthetic peptides with an adjuvant, aims to provoke immune responses against HBV. Given the disease’s global impact, affecting around 296 million people and resulting in over 800,000 deaths annually, this trial may pave the way toward a functional cure for CHB. Additionally, Altimmune is set to initiate a Phase 2b trial for non-alcoholic steatohepatitis (NASH) in mid-2023, with key data from an obesity trial expected in late 2023.
Altimmune, Inc. (Nasdaq: ALT) has appointed Catherine Angell Sohn, Pharm.D., to its Board of Directors, effective March 27, 2023. Her extensive experience in pharmaceutical product development and commercialization is expected to benefit Altimmune’s mission to create next-generation peptide therapeutics for obesity and liver diseases. Currently an independent director at Jazz Pharmaceuticals and Axcella Health, Dr. Sohn previously held strategic roles at GlaxoSmithKline, driving significant acquisitions and launches. She aims to support Altimmune’s clinical pipeline, which includes pemvidutide for obesity and HepTcell™ for chronic hepatitis B.
Altimmune announced the MOMENTUM Phase 2 obesity trial results, reporting a mean weight loss of 10.7% at the 2.4 mg dose after 24 weeks, with 50% of subjects achieving 10% or more weight loss. Significantly, subjects under 115 kg achieved a mean weight loss of 11.9%. Improvements in waist circumference, serum lipids, and blood pressure were also noted without significant heart rate changes. The Phase 1b safety trial for Type 2 diabetes showed 7.7% weight loss at the same dose. Adverse events were similar to earlier trials, primarily gastrointestinal.
Altimmune, Inc. (NASDAQ: ALT) announced its Q4 and full-year 2022 financial results on February 28, 2023, highlighting critical upcoming milestones in its clinical trials. The interim 24-week readout from the MOMENTUM Phase 2 obesity trial is expected in March 2023, while a Phase 2b trial for non-alcoholic steatohepatitis (NASH) will kick off mid-2023. Notable achievements include a 75% reduction in liver fat observed in NAFLD trials and a net loss of $21.7 million for Q4 2022, a decrease from $23.9 million in Q4 2021. The company holds $184.9 million in cash as of December 31, 2022.