Armata Pharmaceuticals Announces Key Opinion Leader Webinar on S. aureus Bacteremia and AP-SA02 Hosted by Jones Research on November 25th at 10:00am EST

Rhea-AI Summary

Armata Pharmaceuticals (NYSE American: ARMP) will host a KOL webinar on November 25, 2025 at 10:00am EST featuring Dr. Vance G. Fowler Jr. on complicated S. aureus bacteremia and Armata's phage therapy AP-SA02.

The company highlighted positive Phase 1b/2a diSArm results presented at IDWeek 2025 showing AP-SA02 plus best available antibiotic therapy produced a higher, earlier cure rate at Test of Cure and a 100% response without relapse at TOC and 28 days later (EOS) versus ~25% lack of response/relapse for placebo plus BAT. AP-SA02 was reported well-tolerated with efficacy against MRSA and MSSA.

Positive

• Higher and earlier cure rate at Test of Cure
• 100% response without relapse at TOC and 28-day EOS
• Well-tolerated safety profile reported
• Efficacy observed against both MRSA and MSSA
• Trends to faster blood culture clearance and reduced ICU/hospital use

Negative

• Results from a Phase 1b/2a study (early-stage evidence)

Insights

Infectious disease clinical development analyst

Positive early clinical signal for AP-SA02 in complicated S. aureus bacteremia with a KOL webinar to disseminate results on November 25, 2025.

Armata reports that its Phase 1b/2a diSArm study showed that intravenous AP-SA02 plus best available antibiotic therapy produced a higher and earlier cure rate at Test of Cure compared to placebo (BAT alone). The release states treated patients had a 100% response rate without relapse at TOC and at end of study versus an approximate 25% lack of response or relapse in the placebo group; AP-SA02 was described as well tolerated and active against both MRSA and MSSA.

The business mechanism is straightforward: positive clinical data increase the scientific credibility of a therapeutic candidate and can accelerate clinical engagement, KOL advocacy, and interest from clinical trial networks. The company will leverage a KOL webinar featuring a high-profile SAB expert to highlight these results to clinicians and researchers, which can broaden clinical awareness and enrollment potential for later studies.

Dependencies and risks are clear from the disclosed facts: these are Phase 1b/2a data, and the announcement cites responder rates and biomarker trends but does not provide full numerical tables, statistical significance, safety event counts, or sample sizes. The robustness of the signal depends on unreported details (sample size, randomization strata, statistical analysis), and later-phase confirmation remains necessary before claiming definitive benefit.

Concrete items to watch include publication or peer-reviewed presentation of the full diSArm dataset, any disclosed sample sizes and p-values, safety event listings, and progress to larger confirmatory studies; the webinar on November 25, 2025 may provide additional detail in the near term.

LOS ANGELES, Nov. 18, 2025 /PRNewswire/ -- Armata Pharmaceuticals, Inc. (NYSE American: ARMP) ("Armata" or the "Company"), a clinical-stage biotechnology company focused on the development of high-purity, pathogen-specific bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections, today announced that the Company will be featured in a key opinion leader (KOL) webinar, "Redefining SoC in Complicated Staph. aureus Bacteremia to Unlock a Real Opportunity" on November 25^th, 2025 at 10:00am EST. Interested parties may register for the event here.

The webinar, which is hosted by Jones Research and Senior Research Analyst, Debanjana Chatterjee, PhD, will feature prominent infectious disease specialist Dr. Vance G. Fowler, Jr., MD, from Duke University School of Medicine. Dr. Fowler will discuss the complicated Staphylococcus aureus ("S. aureus") bacteremia ("SAB") landscape and the potential of Armata's phage therapy, AP‑SA02.

Armata highlighted positive results from its diSArm study of AP-SA02 as a potential treatment for SAB in a late-breaking oral presentation at IDWeek 2025^™ in October:

• The diSArm study was a Phase 1b/2a, multicenter, randomized, double-blind, placebo-controlled, multiple ascending dose escalation study of the safety, tolerability, and efficacy of intravenous AP-SA02 in addition to best available antibiotic therapy ("BAT") compared to BAT alone (placebo) for the treatment of adults with complicated SAB.
  
  
• The primary clinical efficacy endpoint for the Phase 2a portion of the diSArm study was clinical outcome (responder rate) in subjects with complicated bacteremia, measured at (i) Test of Cure ("TOC") for AP-SA02, defined as one week following the end of IV treatment with AP-SA02 (day 12), (ii) TOC for BAT, defined as one week following the end of IV BAT, and (iii) end of study ("EOS"), defined as four weeks following the end of IV BAT.
  
  
• AP-SA02 combined with BAT had a higher and earlier cure rate compared to placebo (BAT alone) in patients with complicated SAB at TOC as assessed by both blinded site investigators and independent adjudicators. Additionally, patients who received AP-SA02 demonstrated a 100% response rate without relapse at TOC for BAT and 28 days later at EOS when compared to the placebo (BAT alone) group which showed an approximate 25% lack of response or relapse rate at both timepoints.
  
  
• AP-SA02 was well-tolerated with clinical efficacy against both methicillin-resistant S. aureus ("MRSA") and methicillin-sensitive S. aureus ("MSSA"), and patients treated with AP-SA02 showed trends toward rapid normalization of key predictors of mortality and complications in SAB including C-reactive protein and interleukin-10, shorter time to negative blood culture, quicker time to resolution of signs and symptoms at the infection site, and shorter intensive care unit and hospital utilization.

Dr. Vance G. Fowler, Jr., MD
Dr. Fowler is the Florence McAlister Distinguished Prof. of Medicine and Prof. of Molecular Genetics and Microbiology at Duke University. He is the Contact PI of the Antibacterial Resistance Leadership Group (ARLG). He created the S. aureus Bacteremia (SAB) Group, one of the world's largest prospective biorepositories of SAB. He is co-founder of the International Collaboration on Endocarditis (ICE), and published the critical observation that S. aureus is now the leading cause of endocarditis in the industrialized world. He was lead author on the Phase 3 trial that led to the FDA indication of daptomycin for SAB (Fowler, NEJM 2006), on the multinational trial of Merck V710 vaccine for S. aureus (Fowler, JAMA 2013), and on the Phase 2 trial (Fowler, J Clin Invest 2020) and Phase 3 trial (DISRUPT; Fowler, CID 2024) of bacteriophage-derived lysin (Exebacase) for S. aureus bacteremia. He was senior author on the recently completed Phase 3 of ceftobiprole for SAB (Holland, NEJM 2023). He has over 350 peer reviewed publications, over 33,000 citations, and a Web of Science h-index of 89.

About Armata Pharmaceuticals, Inc.
Armata is a clinical-stage biotechnology company focused on the development of high-purity pathogen-specific bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other important pathogens. Armata is committed to advancing phage therapy with drug development expertise that spans bench to clinic including in-house phage-specific current Good Manufacturing Practices ("cGMP") manufacturing to support full commercialization.

Forward Looking Statements
This communication contains "forward-looking" statements as defined by the Private Securities Litigation Reform Act of 1995. These statements relate to future events, results or to Armata's future financial performance and involve known and unknown risks, uncertainties and other factors which may cause Armata's actual results, performance or events to be materially different from any future results, performance or events expressed or implied by the forward-looking statements. In some cases, you can identify these statements by terms such as "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "will," "would" or the negative of those terms, and similar expressions. These forward-looking statements reflect management's beliefs and views with respect to future events and are based on estimates and assumptions as of the date of this communication and are subject to risks and uncertainties including risks related to Armata's development of bacteriophage-based therapies; ability to staff and maintain its production facilities under fully compliant cGMP; ability to meet anticipated milestones in the development and testing of the relevant product; ability to be a leader in the development of phage-based therapeutics; ability to achieve its vision, including improvements through engineering and success of clinical trials; ability to successfully complete preclinical and clinical development of, and obtain regulatory approval of its product candidates and commercialize any approved products on its expected timeframes or at all; and Armata's estimates regarding anticipated operating losses, capital requirements and needs for additional funds. Additional risks and uncertainties relating to Armata and its business can be found under the caption "Risk Factors" and elsewhere in Armata's filings and reports with the U.S. Securities and Exchange Commission (the "SEC"), including in Armata's Annual Report on Form 10-K, filed with the SEC on March 21, 2025, and in its subsequent filings with the SEC.

Armata expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Armata's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

Media Contacts:

At Armata:

Pierre Kyme
ir@armatapharma.com
310-665-2928

Investor Relations:

Joyce Allaire
LifeSci Advisors, LLC
jallaire@lifesciadvisors.com
212-915-2569

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SOURCE Armata Pharmaceuticals, Inc.

FAQ

When is Armata's KOL webinar on AP-SA02 and complicated S. aureus bacteremia?

The webinar is scheduled for November 25, 2025 at 10:00am EST.

What Phase of clinical testing reported the AP-SA02 results for ARMP?

AP-SA02 results were reported from the Phase 1b/2a diSArm study presented at IDWeek 2025.

What were the key efficacy findings for AP-SA02 in the diSArm study for ARMP?

AP-SA02 plus BAT showed a higher, earlier cure rate at TOC and 100% response without relapse at TOC and 28 days later (EOS).

Did AP-SA02 show activity against MRSA and MSSA in the ARMP study?

Yes; the company reported clinical efficacy of AP-SA02 against both MRSA and MSSA.

How did AP-SA02 affect hospitalization measures in the diSArm study reported by ARMP?

Patients treated with AP-SA02 showed trends toward shorter ICU and hospital utilization and faster symptom resolution.

Who will present at Armata's webinar and what is his background?

Dr. Vance G. Fowler Jr., a Duke University infectious disease specialist and Contact PI of the Antibacterial Resistance Leadership Group, will present.