Arvinas Announces First-in-Human Dosing of ARV-102, an Investigational PROTAC® Protein Degrader for Neurodegenerative Disease
Arvinas, Inc. announced dosing the first subject in the Phase 1 trial of ARV-102, a novel oral PROTAC protein degrader targeting LRRK2 for neurodegenerative diseases. The drug has shown promising results in preclinical studies, crossing the blood-brain barrier and degrading LRRK2 by nearly 90%. The Phase 1 trial will assess safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
The initiation of the Phase 1 clinical trial for ARV-102 represents a significant advancement in the drug development process, particularly for neurodegenerative diseases like Parkinson’s disease and progressive supranuclear palsy. The ability of ARV-102 to cross the blood-brain barrier and selectively degrade LRRK2 is of high scientific interest. The degradation of LRRK2 by nearly 90% in non-human primates is a promising preclinical result, as LRRK2 is implicated in the pathogenesis of these conditions. However, it is crucial to note that human pharmacokinetics and pharmacodynamics can differ substantially from preclinical models. The safety and tolerability profile of ARV-102 in humans will be a critical factor, as will the drug's ability to achieve the same level of LRRK2 degradation without adverse effects.
From a market perspective, the development of ARV-102 by Arvinas, Inc. is noteworthy due to the innovative approach of using PROTAC technology for neurodegenerative diseases—a therapeutic area with a significant unmet need and high market potential. Investors will be closely watching the outcomes of this Phase 1 trial, as positive results could have substantial implications for Arvinas' valuation and future funding opportunities. The focus on neurodegenerative diseases, which are notoriously difficult to treat, may position Arvinas as a leader in this space if ARV-102 progresses favorably through clinical trials. Nonetheless, the biotechnology sector is highly volatile and early-stage clinical trials have high rates of failure. It is important to manage expectations and consider the long development timelines and regulatory hurdles that lie ahead.
The clinical potential of ARV-102 in treating neurodegenerative diseases is of great interest to the medical community. The targeted approach of PROTACs could represent a paradigm shift in the management of conditions like Parkinson’s disease and progressive supranuclear palsy. Current treatments primarily focus on symptom management and do not halt disease progression. The specificity of PROTACs to degrade pathological proteins like LRRK2 could theoretically modify the disease course. However, while the mechanism of action is compelling, the clinical efficacy and safety in humans remain to be established. The exploration of LRRK2 pathway biomarkers in the trial will also contribute valuable information about the drug's mechanism in a clinical setting, which could inform future therapeutic strategies.
02/20/2024 - 07:00 AM
– ARV-102 is a novel oral PROTAC® protein degrader designed to cross the blood-brain barrier and target leucine-rich repeat kinase 2 (LRRK2) –
– The Phase 1 trial of ARV-102 will evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers –
NEW HAVEN, Conn., Feb. 20, 2024 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today announced that the first subject was dosed in its Phase 1 clinical trial of ARV-102, the Company’s first oral PROTAC® (PROteolysis-TArgeting Chimera) protein degrader in development to treat neurodegenerative diseases. In preclinical studies, ARV-102 has been shown to cross the blood-brain barrier and degrade leucine-rich repeat kinase 2 (LRRK2), which is a large multidomain scaffolding kinase. Increased activity and expressions of LRRK2 is genetically involved in the pathogenesis of neurological diseases including Parkinson’s disease and progressive supranuclear palsy.
In non-human primates, orally administered ARV-102 has been shown to reach deep-brain regions and degrade LRRK2 by nearly 90% . The Phase 1 clinical trial of ARV-102 is enrolling healthy volunteers at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands. The trial will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ARV-102, including the evaluation of LRRK2 degradation and exploratory LRRK2 pathway biomarkers.
“Parkinson’s disease and progressive supranuclear palsy are devastating diseases and this important step of dosing the first healthy volunteer with ARV-102 marks a significant milestone in our commitment to develop transformative therapies for patients living with neurodegenerative diseases,” said Angela M. Cacace, Ph.D., Senior Vice President, Neuroscience and Platform Biology. “There is a high unmet need in many neurologic diseases, and unlike other therapeutic modalities designed to inhibit LRRK2 activity, ARV-102 is an investigational oral PROTAC degrader uniquely designed to cross the blood-brain barrier and degrade the LRRK2 protein. As a pioneer in targeted protein degradation, we believe that PROTAC degraders have great potential to change the treatment paradigm for patients with neurodegenerative diseases.”
John Houston, Ph.D., Chairperson, Chief Executive Officer, and President, and Angela M. Cacace, Ph.D., Senior Vice President, Neuroscience and Platform Biology, provided an update on recent progress with ARV-102, as well as Arvinas’ preclinical pipeline of PROTAC protein degraders directed towards neurological disorders, in a webcast available on the Events & Presentations section of the Investors and Media section of the Company’s website .
About Arvinas www.arvinas.com .
Arvinas Forward-Looking Statements
Arvinas may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on such forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements made as a result of various risks and uncertainties, including but not limited to: whether Arvinas will be able to successfully conduct and complete clinical development forARV-102 on our current timelines or at all; Arvinas’ approach to the discovery and development of product candidates based on its PROTAC technology platform is unproven, which makes it difficult to predict the time, cost of development and likelihood of successfully developing any products; Arvinas’ ability to protect its intellectual property position; whether cash and cash equivalent resources will be sufficient to fund Arvinas’ foreseeable and unforeseeable operating expenses and capital expenditure requirements; and other important factors discussed in the “Risk Factors” section of the company’s Annual Report on Form 10-K for the year ended December 31, 2022, and subsequent other reports on file with the U.S. Securities and Exchange Commission. The forward-looking statements contained in this press release reflect current views with respect to future events, and Arvinas assumes no obligation to update any forward-looking statements except as required by applicable law. These forward-looking statements should not be relied upon as representing Arvinas’ views as of any date after the date of this release.
Arvinas Contacts
Investor Contact: Jeff.Boyle@arvinas.com
Media Contact: Kathleen.Murphy@arvinas.com
What is the purpose of the Phase 1 trial for ARV-102 (ARVN)?
The Phase 1 trial of ARV-102 aims to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
What is the target of ARV-102 (ARVN)?
ARV-102 targets leucine-rich repeat kinase 2 (LRRK2) for neurodegenerative diseases.
Where is the Phase 1 trial of ARV-102 (ARVN) being conducted?
The Phase 1 trial of ARV-102 is enrolling healthy volunteers at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands.
What milestone was achieved by dosing the first subject in the Phase 1 trial of ARV-102 (ARVN)?
Dosing the first subject marked a significant milestone in developing transformative therapies for patients with neurodegenerative diseases.
How does ARV-102 (ARVN) differ from other therapeutic modalities targeting LRRK2?
ARV-102 is an investigational oral PROTAC degrader uniquely designed to cross the blood-brain barrier and degrade the LRRK2 protein.
