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Arrowhead Pharmaceuticals develops and commercializes RNA interference medicines that silence genes associated with intractable diseases. The company’s TRiM™ platform is used to design targeted RNAi therapeutics for tissues including liver, lung, muscle, adipose and central nervous system tissue.
Recurring ARWR news covers REDEMPLO® (plozasiran), an siRNA medicine approved in the United States and Australia as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome. Company updates also address plozasiran data across hypertriglyceridemia, regulatory actions in additional geographies, pricing and market-access strategy, fiscal results, investor events, and clinical or partnering developments involving programs such as ARO-PNPLA3, ARO-INHBE and ARO-ALK7.
Arrowhead Pharmaceuticals has reported positive results from its Phase 2b ARCHES-2 study on zodasiran (ARO-ANG3) for treating mixed hyperlipidemia. The treatment showed significant reductions in triglycerides, LDL-C, and other atherogenic lipoproteins at 24 weeks. Zodasiran also demonstrated a favorable safety profile with balanced adverse events between treatment and placebo groups. These findings were presented at the European Atherosclerosis Society 92nd Congress and published in the New England Journal of Medicine.
The study included various doses (50, 100, and 200 mg) and highlighted dose-dependent efficacy with the highest dose achieving up to a 63% reduction in triglycerides and 74% reduction in ANGPTL3 levels compared to placebo. Additionally, liver fat reductions were observed in patients with higher baseline liver fat fractions.
Arrowhead Pharmaceuticals presented Phase 2 data for its investigational drug plozasiran at the European Atherosclerosis Society 92nd Congress. The drug significantly reduced triglyceride levels in patients with mixed hyperlipidemia, showing reductions in APOC3, non-HDL-C, and remnant cholesterol. These results were also published in the New England Journal of Medicine. In the MUIR study, plozasiran achieved -50% to -62% reductions in triglycerides and normalization in up to 92% of patients. Significant reductions in other atherogenic lipoproteins were also observed. Plozasiran demonstrated a favorable safety profile with comparable treatment-emergent adverse events (TEAEs) to placebo. Arrowhead will continue to investigate the drug in Phase 3 studies.
Arrowhead Pharmaceuticals announced interim clinical data for ARO-RAGE, an investigational RNAi-based medicine for inflammatory lung diseases like asthma. The data revealed significant reductions in soluble RAGE (sRAGE) levels in both bronchoalveolar lavage fluid (BALF) and serum among healthy volunteers and asthma patients. ARO-RAGE achieved up to 88% reduction in sRAGE in asthma patients after two doses, with sustained effects supporting bi-monthly dosing. The treatment demonstrated a favorable safety profile with no serious adverse effects. Additionally, Arrowhead presented promising preclinical results for therapies targeting thymic stromal lymphopoietin (TSLP) and influenza A viruses.
Arrowhead Pharmaceuticals, Inc. reported its fiscal 2024 second quarter results, showcasing progress in its RNAi-based medicines. The company received a $50 million milestone payment, presented positive data from its plozasiran study, and initiated an Expanded Access Program. Additionally, Arrowhead strengthened its balance sheet through a stock offering. Financially, the company reported a net loss and increased cash reserves.
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) received a $50 million milestone payment from Royalty Pharma plc for completing enrollment in the Phase 3 OCEAN(a) - Outcomes Trial of olpasiran, being conducted by Amgen. Arrowhead stands to earn up to an additional $375 million from Amgen and $110 million from Royalty Pharma in milestone payments related to olpasiran. The rapid enrollment in the trial reflects the interest in olpasiran, developed using Arrowhead's TRiMTM technology. With three Phase 3 programs in progress, including plozasiran, Arrowhead continues to advance RNA interference therapies.
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) announced its participation in various upcoming conferences in May 2024. The events include presentations on innovative therapies targeting different diseases like ALS, asthma, influenza, dyslipidemia, and others. Several key researchers will present the latest findings on RNA interference therapies, showcasing the company's advancements in the field.
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